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Dyne Therapeutics

205 hedge funds and large institutions have $1.29B invested in Dyne Therapeutics in 2025 Q1 according to their latest regulatory filings, with 49 funds opening new positions, 81 increasing their positions, 45 reducing their positions, and 43 closing their positions.

New
Increased
Maintained
Reduced
Closed

369% more call options, than puts

Call options by funds: $3.39M | Put options by funds: $724K

80% more repeat investments, than reductions

Existing positions increased: 81 | Existing positions reduced: 45

14% more first-time investments, than exits

New positions opened: 49 | Existing positions closed: 43

3% more funds holding

Funds holding: 200205 (+5)

1.83% less ownership

Funds ownership: 109.69%107.86% (-1.8%)

29% less funds holding in top 10

Funds holding in top 10: 75 (-2)

51% less capital invested

Capital invested by funds: $2.63B → $1.29B (-$1.34B)

Holders
205
Holders Change
+5
Holders Change %
+2.5%
% of All Funds
2.75%
Holding in Top 10
5
Holding in Top 10 Change
-2
Holding in Top 10 Change %
-28.57%
% of All Funds
0.07%
New
49
Increased
81
Reduced
45
Closed
43
Calls
$3.39M
Puts
$724K
Net Calls
+$2.67M
Net Calls Change
+$9.39M
Name Holding Trade Value Shares
Change
Change in
Stake
Janus Henderson Group
1
Janus Henderson Group
United Kingdom
$118M +$42.5M +2,974,107 +40%
RCM
2
RA Capital Management
Massachusetts
$102M +$47.7M +3,333,248 +52%
AVLSA
3
Atlas Venture Life Science Advisors
Massachusetts
$95.5M +$15.9M +1,111,111 +14%
BlackRock
4
BlackRock
New York
$84.2M +$1.4M +97,536 +1%
Vanguard Group
5
Vanguard Group
Pennsylvania
$77.5M +$10M +702,418 +10%
FIS
6
FCPM III Services
Netherlands
$57.1M
Fidelity Investments
7
Fidelity Investments
Massachusetts
$54.3M -$40.1M -2,801,637 -35%
B
8
Braidwell
Connecticut
$37.9M +$42.1M +2,940,162 +432%
State Street
9
State Street
Massachusetts
$37.8M -$1.54M -107,732 -3%
Citadel Advisors
10
Citadel Advisors
Florida
$31.5M +$2.11M +147,808 +5%
AC
11
Armistice Capital
New York
$29M +$25.8M +1,803,482 +187%
SL
12
Siren LLC
Connecticut
$28.4M +$19.6M +1,370,531 +102%
TCM
13
TCG Crossover Management
California
$27.7M
JP Morgan Chase
14
JP Morgan Chase
New York
$26.5M +$34.8M +2,432,926 +2,473%
PA
15
Perceptive Advisors
New York
$24.2M +$25.3M +1,770,126 +326%
VA
16
VR Adviser
New York
$22.7M
DTC
17
Deep Track Capital
Connecticut
$20.9M
Geode Capital Management
18
Geode Capital Management
Massachusetts
$20.5M +$975K +68,176 +4%
T. Rowe Price Associates
19
T. Rowe Price Associates
Maryland
$19M -$8.33M -582,037 -24%
VPC
20
Vestal Point Capital
New York
$18.8M +$25.7M +1,800,000 New
RI
21
RTW Investments
New York
$17.7M -$50.5M -3,528,074 -68%
Point72 Asset Management
22
Point72 Asset Management
Connecticut
$16M +$8.64M +603,853 +65%
FLSM
23
Frazier Life Sciences Management
California
$15.1M +$20.6M +1,443,341 New
Franklin Resources
24
Franklin Resources
California
$14.8M +$1.3M +91,032 +7%
Morgan Stanley
25
Morgan Stanley
New York
$14.6M +$9.13M +637,994 +85%

DYN Hedge Fund Activity: Q1 2025 in Review

205 of the 7,457 institutional investors tracked by Wall St. Rank reported a position in Dyne Therapeutics (DYN) for Q1 2025, worth a combined $1.29B — down 51% from $2.63B a quarter earlier.

Buyers outnumbered sellers: 49 funds opened new DYN positions and 43 closed out — a net gain of 6 holders — while 81 added to existing stakes and 45 trimmed.

The largest buyer was RA Capital Management, adding an estimated $47.7M. The largest seller was Holocene Advisors, exiting entirely with an estimated $55.3M sold.

  • 205 institutional investors held Dyne Therapeutics (DYN) as of Q1 2025, up from 200 in Q4 2024.
  • Funds reported $1.29B of Dyne Therapeutics stock for Q1 2025, down 51% quarter-over-quarter.
  • 49 funds opened new Dyne Therapeutics positions in Q1 2025 and 43 closed out, a net change of +6 holders.
  • The largest Dyne Therapeutics buyer in Q1 2025 was RA Capital Management, an estimated $47.7M added.
  • The largest Dyne Therapeutics seller in Q1 2025 was Holocene Advisors, an estimated $55.3M sold.

Based on aggregated 13F filings for Q1 2025.