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DFTX

Definium Therapeutics
DFTX

195 hedge funds and large institutions have $469M invested in Definium Therapeutics in 2025 Q3 according to their latest regulatory filings, with 39 funds opening new positions, 56 increasing their positions, 48 reducing their positions, and 23 closing their positions.

New
Increased
Maintained
Reduced
Closed

96% more call options, than puts

Call options by funds: $21.3M | Put options by funds: $10.9M

73% more capital invested

Capital invested by funds: $271M → $469M (+$198M)

70% more first-time investments, than exits

New positions opened: 39 | Existing positions closed: 23

17% more repeat investments, than reductions

Existing positions increased: 56 | Existing positions reduced: 48

8% more funds holding

Funds holding: 181 → 195 (+14)

0% more funds holding in top 10

Funds holding in top 10: 3 → 3 (0)

3.09% less ownership

Funds ownership: 55.32% → 52.23% (-3.1%)

Holders
195
Holders Change
+14
Holders Change %
+7.73%
% of All Funds
2.56%
Holding in Top 10
3
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.04%
New
39
Increased
56
Reduced
48
Closed
23
Calls
$21.3M
Puts
$10.9M
Net Calls
+$10.4M
Net Calls Change
+$7.9M

Top Buyers

1
Goldman Sachs
Goldman Sachs
New York
+$4.18M
2
O
OrbiMed
New York
+$3.43M
3
RA
Rosalind Advisors
Ontario, Canada
+$3.08M
4
Adage Capital Partners
Adage Capital Partners
Massachusetts
+$2.8M
5
Two Sigma Investments
Two Sigma Investments
New York
+$2.24M

Top Sellers

1
CC
Commodore Capital
New York
-$16.6M
2
Marshall Wace
Marshall Wace
United Kingdom
-$9.69M
3
DTC
Deep Track Capital
Connecticut
-$9.33M
4
Blackstone Inc
Blackstone Inc
New York
-$7.56M
5
ABG
Ally Bridge Group
New York
-$3.4M
Name Holding Trade Value Shares
Change 		Change in
Stake
MMPW
201
Mitchell McLeod Pugh & Williams
Alabama
– -$130K -20,000 Closed
Squarepoint
202
Squarepoint
New York
– -$128K -19,684 Closed
ECM
203
ExodusPoint Capital Management
New York
– -$116K -17,877 Closed
B
204
Bailard
California
– -$94.8K -14,600 Closed
DC
205
Diametric Capital
Massachusetts
– -$80.7K -12,433 Closed
PEAK6
206
PEAK6
Illinois
– -$102K -10,915 Closed
S
207
SharpePoint
Arizona
– -$66K -10,165 Closed
SSG
208
Summit Securities Group
New York
– -$20.1K -3,096 Closed
LFG
209
Larson Financial Group
Missouri
– -$19K -2,932 Closed
BIG
210
Brooklyn Investment Group
New York
– -$3.37K -519 Closed
AAP
211
Arax Advisory Partners
Colorado
– -$3.25K -501 Closed
CIAM
212
Caitong International Asset Management
Hong Kong
– -$2.21K -341 Closed
CWM
213
CarsonAllaria Wealth Management
Illinois
– -$2.11K -325 Closed
PW
214
Pandora Wealth
Illinois
– -$850 -131 Closed
FPF
215
First Pacific Financial
Washington
– -$662 -102 Closed
TCM
216
TruNorth Capital Management
Michigan
– -$214 -33 Closed
TIM
217
Total Investment Management
Arizona
– -$130 -20 Closed
5 6 7 8
9

DFTX Hedge Fund Activity: Q3 2025 in Review

195 of the 7,619 institutional investors tracked by Wall St. Rank reported a position in Definium Therapeutics (DFTX) for Q3 2025, worth a combined $469M — up 73% from $271M a quarter earlier.

Buyers outnumbered sellers: 39 funds opened new DFTX positions and 23 closed out — a net gain of 16 holders — while 56 added to existing stakes and 48 trimmed.

The largest buyer was Goldman Sachs, adding an estimated $4.18M. The largest seller was Commodore Capital, cutting an estimated $16.6M.

  • 195 institutional investors held Definium Therapeutics (DFTX) as of Q3 2025, up from 181 in Q2 2025.
  • Funds reported $469M of Definium Therapeutics stock for Q3 2025, up 73% quarter-over-quarter.
  • 39 funds opened new Definium Therapeutics positions in Q3 2025 and 23 closed out, a net change of +16 holders.
  • The largest Definium Therapeutics buyer in Q3 2025 was Goldman Sachs, an estimated $4.18M added.
  • The largest Definium Therapeutics seller in Q3 2025 was Commodore Capital, an estimated $16.6M sold.

Based on aggregated 13F filings for Q3 2025.