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DFTX

Definium Therapeutics
DFTX

195 hedge funds and large institutions have $469M invested in Definium Therapeutics in 2025 Q3 according to their latest regulatory filings, with 39 funds opening new positions, 56 increasing their positions, 48 reducing their positions, and 23 closing their positions.

New
Increased
Maintained
Reduced
Closed

96% more call options, than puts

Call options by funds: $21.3M | Put options by funds: $10.9M

73% more capital invested

Capital invested by funds: $271M → $469M (+$198M)

70% more first-time investments, than exits

New positions opened: 39 | Existing positions closed: 23

17% more repeat investments, than reductions

Existing positions increased: 56 | Existing positions reduced: 48

8% more funds holding

Funds holding: 181 → 195 (+14)

0% more funds holding in top 10

Funds holding in top 10: 3 → 3 (0)

3.09% less ownership

Funds ownership: 55.32% → 52.23% (-3.1%)

Holders
195
Holders Change
+14
Holders Change %
+7.73%
% of All Funds
2.56%
Holding in Top 10
3
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.04%
New
39
Increased
56
Reduced
48
Closed
23
Calls
$21.3M
Puts
$10.9M
Net Calls
+$10.4M
Net Calls Change
+$7.9M

Top Buyers

1
Goldman Sachs
Goldman Sachs
New York
+$4.18M
2
O
OrbiMed
New York
+$3.43M
3
RA
Rosalind Advisors
Ontario, Canada
+$3.08M
4
Adage Capital Partners
Adage Capital Partners
Massachusetts
+$2.8M
5
Two Sigma Investments
Two Sigma Investments
New York
+$2.24M

Top Sellers

1
CC
Commodore Capital
New York
-$16.6M
2
Marshall Wace
Marshall Wace
United Kingdom
-$9.69M
3
DTC
Deep Track Capital
Connecticut
-$9.33M
4
Blackstone Inc
Blackstone Inc
New York
-$7.56M
5
ABG
Ally Bridge Group
New York
-$3.4M
Name Holding Trade Value Shares
Change 		Change in
Stake
BNP Paribas Asset Management
151
BNP Paribas Asset Management
France
$9K +$1.06K +114 +17%
ASN
152
Advisory Services Network
Georgia
$7.74K +$6.12K +656 New
Walleye Trading
153
Walleye Trading
New York
$6.63K +$5.24K +562 New
HI
154
Harbour Investments
Wisconsin
$6.55K – – –
GRP
155
Global Retirement Partners
California
$5.89K +$4.66K +500 New
FFA
156
Farther Finance Advisors
California
$5.39K – – –
MPWT
157
MassMutual Private Wealth & Trust
Connecticut
$5.09K – – –
NL
158
NVWM LLC
Pennsylvania
$4.91K – – –
TIM
159
Tortoise Investment Management
New York
$4.72K – – –
Rockefeller Capital Management
160
Rockefeller Capital Management
New York
$4.14K +$3.27K +351 New
RIL
161
Rothschild Investment LLC
Illinois
$3.22K – – –
Daiwa Securities Group
162
Daiwa Securities Group
Japan
$3K – – –
PA
163
Parallel Advisors
California
$2.74K -$187 -20 -8%
Optiver Holding
164
Optiver Holding
Netherlands
$2.57K +$2.03K +218 New
AEPWM
165
Atlantic Edge Private Wealth Management
Florida
$2.28K – – –
Northwestern Mutual Wealth Management
166
Northwestern Mutual Wealth Management
Wisconsin
$1.96K -$4.36K -467 -74%
CIBC Private Wealth Group
167
CIBC Private Wealth Group
Georgia
$1.78K -$3.11K -333 -69%
NA
168
NewEdge Advisors
Louisiana
$1.67K – – –
SS
169
SBI Securities
Japan
$1.24K -$2.58K -277 -73%
EWA
170
EverSource Wealth Advisors
Alabama
$1.23K +$131 +14 +16%
NS
171
NBC Securities
Alabama
$1.18K -$4.66K -500 -83%
HWM
172
HighMark Wealth Management
Minnesota
$1.18K – – –
AF
173
Allworth Financial
California
$1K – – –
AWM
174
Activest Wealth Management
Florida
$778 – – –
GA
175
Guerra Advisors
Florida
$778 +$616 +66 New
5 6
7
8 9

DFTX Hedge Fund Activity: Q3 2025 in Review

195 of the 7,619 institutional investors tracked by Wall St. Rank reported a position in Definium Therapeutics (DFTX) for Q3 2025, worth a combined $469M — up 73% from $271M a quarter earlier.

Buyers outnumbered sellers: 39 funds opened new DFTX positions and 23 closed out — a net gain of 16 holders — while 56 added to existing stakes and 48 trimmed.

The largest buyer was Goldman Sachs, adding an estimated $4.18M. The largest seller was Commodore Capital, cutting an estimated $16.6M.

  • 195 institutional investors held Definium Therapeutics (DFTX) as of Q3 2025, up from 181 in Q2 2025.
  • Funds reported $469M of Definium Therapeutics stock for Q3 2025, up 73% quarter-over-quarter.
  • 39 funds opened new Definium Therapeutics positions in Q3 2025 and 23 closed out, a net change of +16 holders.
  • The largest Definium Therapeutics buyer in Q3 2025 was Goldman Sachs, an estimated $4.18M added.
  • The largest Definium Therapeutics seller in Q3 2025 was Commodore Capital, an estimated $16.6M sold.

Based on aggregated 13F filings for Q3 2025.