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C4 Therapeutics
CCCC

Name Holding Trade Value Shares
Change 		Change in
Stake
PA
1
Perceptive Advisors
New York
$105M +$91.6M +3,158,566 New
CAM
2
Cormorant Asset Management
Massachusetts
$80M +$72.2M +2,490,065 New
RI
3
RTW Investments
New York
$68.7M +$62.3M +2,149,228 New
BCLSI
4
Bain Capital Life Sciences Investors
Massachusetts
$54.4M +$47.6M +1,642,209 New
T. Rowe Price Associates
5
T. Rowe Price Associates
Maryland
$49.4M +$44.4M +1,530,042 New
RCM
6
RA Capital Management
Massachusetts
$45.6M +$39.9M +1,377,569 New
Janus Henderson Group
7
Janus Henderson Group
$40.4M +$37.6M +1,297,609 New
BlackRock
8
BlackRock
New York
$37.8M +$33M +1,139,591 New
Adage Capital Partners
9
Adage Capital Partners
Massachusetts
$29.5M +$25.8M +890,498 New
Fidelity Investments
10
Fidelity Investments
Massachusetts
$22.2M +$19.5M +671,287 New
Millennium Management
11
Millennium Management
New York
$18.4M +$16.1M +554,568 New
CC
12
Commodore Capital
New York
$15.9M +$14M +481,094 New
LGM
13
Logos Global Management
California
$15.8M +$13.9M +477,928 New
Vanguard Group
14
Vanguard Group
Pennsylvania
$15M +$13.1M +452,167 New
SFM
15
Sphera Funds Management
Israel
$14.6M +$12.9M +443,824 New
Invesco
16
Invesco
Georgia
$9.96M +$8.72M +300,542 New
SCM
17
Soleus Capital Management
Connecticut
$8.9M +$7.79M +268,548 New
ACH
18
ArrowMark Colorado Holdings
Colorado
$8.25M +$7.23M +249,149 New
DGM
19
Darwin Global Management
Jersey
$7.57M +$6.63M +228,595 New
EC
20
EcoR1 Capital
California
$6.63M +$5.8M +200,000 New
Geode Capital Management
21
Geode Capital Management
Massachusetts
$6.27M +$5.49M +189,251 New
Jennison Associates
22
Jennison Associates
New York
$5.74M +$5.03M +173,352 New
MS
23
Mizuho Securities
Japan
$5.61M +$4.91M +169,392 New
WP
24
Woodline Partners
California
$5.51M +$4.82M +166,323 New
State Street
25
State Street
Massachusetts
$5.47M +$4.79M +165,131 New
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