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CalciMedica
CALC

27 hedge funds and large institutions have $593K invested in CalciMedica in 2026 Q1 according to their latest regulatory filings, with 11 funds opening new positions, 4 increasing their positions, 5 reducing their positions, and 12 closing their positions.

New
Increased
Maintained
Reduced
Closed

8% less first-time investments, than exits

New positions opened: 11 | Existing positions closed: 12

10% less funds holding

Funds holding: 30 → 27 (-3)

18.39% less ownership

Funds ownership: 25.37% → 6.97% (-18%)

20% less repeat investments, than reductions

Existing positions increased: 4 | Existing positions reduced: 5

98% less capital invested

Capital invested by funds: $24.1M → $593K (-$23.5M)

100% less funds holding in top 10

Funds holding in top 10: 1 → 0 (-1)

Holders
27
Holders Change
-3
Holders Change %
-10%
% of All Funds
0.33%
Holding in Top 10
–
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-100%
% of All Funds
–
New
11
Increased
4
Reduced
5
Closed
12
Calls
$10K
Puts
–
Net Calls
+$10K
Net Calls Change
+$10K

Top Buyers

1
Jane Street
Jane Street
New York
+$323K
2
1WA
180 Wealth Advisors
Washington
+$192K
3
Cambridge Investment Research Advisors
Cambridge Investment Research Advisors
Iowa
+$122K
4
Renaissance Technologies
Renaissance Technologies
New York
+$80.7K
5
HF
HRT Financial
New York
+$80.6K

Top Sellers

1
DM
Deerfield Management
New York
-$8.57M
2
SCM
Soleus Capital Management
Connecticut
-$4.51M
3
ACM
Aisling Capital Management
New York
-$3.43M
4
BFM
Boothbay Fund Management
New York
-$506K
5
Envestnet Asset Management
Envestnet Asset Management
Illinois
-$416K
Name Holding Trade Value Shares
Change 		Change in
Stake
Jane Street
1
Jane Street
New York
$96.4K +$323K +159,312 +830%
VCM
2
Vanguard Capital Management
Pennsylvania
$91.3K +$343K +169,110 New
Renaissance Technologies
3
Renaissance Technologies
New York
$69.2K +$80.7K +39,775 +45%
1WA
4
180 Wealth Advisors
Washington
$68.3K +$192K +94,650 +297%
Geode Capital Management
5
Geode Capital Management
Massachusetts
$66.7K +$47.9K +23,595 +24%
Cambridge Investment Research Advisors
6
Cambridge Investment Research Advisors
Iowa
$32K +$122K +60,000 New
SFFS
7
Stonehage Fleming Financial Services
Jersey
$29K – – –
VFT
8
Vanguard Fiduciary Trust
Pennsylvania
$24.7K +$93K +45,829 New
HF
9
HRT Financial
New York
$21K +$80.6K +39,699 New
Susquehanna International Group
10
Susquehanna International Group
Pennsylvania
$16.6K +$62.3K +30,716 New
GCP
11
GSA Capital Partners
United Kingdom
$13K +$48.3K +23,777 New
VF
12
Virtu Financial
New York
$10K +$36.3K +17,895 New
State Street
13
State Street
Massachusetts
$9.22K +$34.6K +17,073 New
TP
14
TritonPoint Partners
Maryland
$8.16K – – –
First Manhattan
15
First Manhattan
New York
$7.14K – – –
Simplex Trading
16
Simplex Trading
Illinois
$6.92K +$26K +12,816 New
Northern Trust
17
Northern Trust
Illinois
$6.77K – – –
GSC
18
Ground Swell Capital
South Carolina
$6.65K +$25K +12,307 New
SVWAG
19
Sound View Wealth Advisors Group
Georgia
$5.4K -$20.5K -10,100 -50%
Rockefeller Capital Management
20
Rockefeller Capital Management
New York
$2.7K -$10.1K -5,000 -50%
TRCT
21
Tower Research Capital (TRC)
New York
$1.09K +$4.1K +2,022 New
BBHC
22
Brown Brothers Harriman & Co
New York
$166 – – –
Osaic Holdings
23
Osaic Holdings
Arizona
$58 – – –
SS
24
SBI Securities
Japan
$47 -$6 -3 -3%
UBS Group
25
UBS Group
Switzerland
$9 -$2.2K -1,083 -98%
1
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CALC Hedge Fund Activity: Q1 2026 in Review

27 of the 8,126 institutional investors tracked by Wall St. Rank reported a position in CalciMedica (CALC) for Q1 2026, worth a combined $593K — down 98% from $24.1M a quarter earlier.

Sellers outnumbered buyers: 12 funds closed out of CALC and 11 opened new positions — a net loss of 1 holder — while 5 trimmed existing stakes and 4 added.

The largest buyer was Jane Street, adding an estimated $323K. The largest seller was Deerfield Management, exiting entirely with an estimated $8.57M sold.

  • 27 institutional investors held CalciMedica (CALC) as of Q1 2026, down from 30 in Q4 2025.
  • Funds reported $593K of CalciMedica stock for Q1 2026, down 98% quarter-over-quarter.
  • 11 funds opened new CalciMedica positions in Q1 2026 and 12 closed out, a net change of -1 holder.
  • The largest CalciMedica buyer in Q1 2026 was Jane Street, an estimated $323K added.
  • The largest CalciMedica seller in Q1 2026 was Deerfield Management, an estimated $8.57M sold.

Based on aggregated 13F filings for Q1 2026.