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CalciMedica
CALC

31 hedge funds and large institutions have $10.9M invested in CalciMedica in 2025 Q3 according to their latest regulatory filings, with 7 funds opening new positions, 5 increasing their positions, 10 reducing their positions, and 6 closing their positions.

New
Increased
Maintained
Reduced
Closed

85% more capital invested

Capital invested by funds: $5.93M → $10.9M (+$5.02M)

17% more first-time investments, than exits

New positions opened: 7 | Existing positions closed: 6

3% more funds holding

Funds holding: 30 → 31 (+1)

1.13% less ownership

Funds ownership: 26.67% → 25.54% (-1.1%)

50% less repeat investments, than reductions

Existing positions increased: 5 | Existing positions reduced: 10

100% less funds holding in top 10

Funds holding in top 10: 1 → 0 (-1)

Holders
31
Holders Change
+1
Holders Change %
+3.33%
% of All Funds
0.41%
Holding in Top 10
–
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-100%
% of All Funds
–
New
7
Increased
5
Reduced
10
Closed
6
Calls
–
Puts
–
Net Calls
–
Net Calls Change
–

Top Buyers

1
SFFS
Stonehage Fleming Financial Services
Jersey
+$154K
2
SSIM
Sheets Smith Investment Management
Texas
+$147K
3
Vanguard Group
Vanguard Group
Pennsylvania
+$108K
4
Renaissance Technologies
Renaissance Technologies
New York
+$97.8K
5
SF
Summit Financial
New Jersey
+$72.2K

Top Sellers

1
SCM
Soleus Capital Management
Connecticut
-$288K
2
WIA
Wealthedge Investment Advisors
New York
-$140K
3
SCM
Stonepine Capital Management
Oregon
-$136K
4
Corient Private Wealth
Corient Private Wealth
Florida
-$60.8K
5
Millennium Management
Millennium Management
New York
-$53.2K
Name Holding Trade Value Shares
Change 		Change in
Stake
DM
1
Deerfield Management
New York
$4M – – –
SCM
2
Soleus Capital Management
Connecticut
$2.1M -$288K -100,000 -13%
ACM
3
Aisling Capital Management
New York
$1.6M – – –
Vanguard Group
4
Vanguard Group
Pennsylvania
$1.14M +$108K +37,476 +11%
Geode Capital Management
5
Geode Capital Management
Massachusetts
$299K +$5.24K +1,820 +2%
Envestnet Asset Management
6
Envestnet Asset Management
Illinois
$236K -$48.1K -16,728 -18%
Renaissance Technologies
7
Renaissance Technologies
New York
$215K +$97.8K +34,000 +94%
MPM
8
Meritage Portfolio Management
Kansas
$189K +$44.7K +15,539 +34%
SFFS
9
Stonehage Fleming Financial Services
Jersey
$165K +$154K +53,703 New
SSIM
10
Sheets Smith Investment Management
Texas
$157K +$147K +51,100 New
1WA
11
180 Wealth Advisors
Washington
$131K -$22.3K -7,750 -15%
AI
12
Atria Investments
North Carolina
$117K -$19K -6,614 -15%
Millennium Management
13
Millennium Management
New York
$104K -$53.2K -18,482 -35%
Cetera Investment Advisers
14
Cetera Investment Advisers
Illinois
$78K -$31.7K -11,020 -30%
SF
15
Summit Financial
New Jersey
$77.3K +$72.2K +25,092 New
SVWAG
16
Sound View Wealth Advisors Group
Georgia
$61.8K – – –
JGC
17
J. Goldman & Co
New York
$58.1K – – –
TW
18
TritonPoint Wealth
Maryland
$46.5K – – –
XT
19
XTX Topco
Cayman Islands
$46.3K +$44.1K +15,345 New
First Manhattan
20
First Manhattan
New York
$40.7K – – –
Rockefeller Capital Management
21
Rockefeller Capital Management
New York
$30.8K +$28.8K +10,000 New
Bank of America
22
Bank of America
North Carolina
$27.8K -$23 -8 -0.1%
Citigroup
23
Citigroup
New York
$15.2K +$14.2K +4,927 New
Osaic Holdings
24
Osaic Holdings
Arizona
$3.19K -$5.46K -1,898 -65%
Morgan Stanley
25
Morgan Stanley
New York
$2.63K – – –
1
2

CALC Hedge Fund Activity: Q3 2025 in Review

31 of the 7,619 institutional investors tracked by Wall St. Rank reported a position in CalciMedica (CALC) for Q3 2025, worth a combined $10.9M — up 85% from $5.93M a quarter earlier.

Buyers outnumbered sellers: 7 funds opened new CALC positions and 6 closed out — a net gain of 1 holder — while 5 added to existing stakes and 10 trimmed.

The largest buyer was Stonehage Fleming Financial Services, opening a new position worth an estimated $154K. The largest seller was Soleus Capital Management, cutting an estimated $288K.

  • 31 institutional investors held CalciMedica (CALC) as of Q3 2025, up from 30 in Q2 2025.
  • Funds reported $10.9M of CalciMedica stock for Q3 2025, up 85% quarter-over-quarter.
  • 7 funds opened new CalciMedica positions in Q3 2025 and 6 closed out, a net change of +1 holder.
  • The largest CalciMedica buyer in Q3 2025 was Stonehage Fleming Financial Services, an estimated $154K added.
  • The largest CalciMedica seller in Q3 2025 was Soleus Capital Management, an estimated $288K sold.

Based on aggregated 13F filings for Q3 2025.