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CalciMedica
CALC

30 hedge funds and large institutions have $24.1M invested in CalciMedica in 2025 Q4 according to their latest regulatory filings, with 6 funds opening new positions, 5 increasing their positions, 8 reducing their positions, and 6 closing their positions.

New
Increased
Maintained
Reduced
Closed

120% more capital invested

Capital invested by funds: $10.9M → $24.1M (+$13.1M)

0% more first-time investments, than exits

New positions opened: 6 | Existing positions closed: 6

0.18% less ownership

Funds ownership: 25.54% → 25.37% (-0.18%)

3% less funds holding

Funds holding: 31 → 30 (-1)

38% less repeat investments, than reductions

Existing positions increased: 5 | Existing positions reduced: 8

Holders
30
Holders Change
-1
Holders Change %
-3.23%
% of All Funds
0.36%
Holding in Top 10
1
Holding in Top 10 Change
+1
Holding in Top 10 Change %
% of All Funds
0.01%
New
6
Increased
5
Reduced
8
Closed
6
Calls
–
Puts
–
Net Calls
–
Net Calls Change
–

Top Buyers

1
BFM
Boothbay Fund Management
New York
+$300K
2
PAM
PVG Asset Management
Colorado
+$179K
3
Vanguard Group
Vanguard Group
Pennsylvania
+$122K
4
Jane Street
Jane Street
New York
+$74.9K
5
Renaissance Technologies
Renaissance Technologies
New York
+$71.4K

Top Sellers

1
Millennium Management
Millennium Management
New York
-$76.2K
2
Envestnet Asset Management
Envestnet Asset Management
Illinois
-$52.7K
3
TW
TritonPoint Wealth
Maryland
-$46.5K
4
XT
XTX Topco
Cayman Islands
-$46.3K
5
1WA
180 Wealth Advisors
Washington
-$42.3K
Name Holding Trade Value Shares
Change 		Change in
Stake
DM
1
Deerfield Management
New York
$8.57M – – –
SCM
2
Soleus Capital Management
Connecticut
$4.51M – – –
ACM
3
Aisling Capital Management
New York
$3.43M – – –
Vanguard Group
4
Vanguard Group
Pennsylvania
$2.69M +$122K +31,177 +8%
Geode Capital Management
5
Geode Capital Management
Massachusetts
$658K +$3.65K +935 +0.9%
Renaissance Technologies
6
Renaissance Technologies
New York
$582K +$71.4K +18,300 +26%
BFM
7
Boothbay Fund Management
New York
$506K +$300K +76,855 New
Envestnet Asset Management
8
Envestnet Asset Management
Illinois
$416K -$52.7K -13,519 -18%
MPM
9
Meritage Portfolio Management
Kansas
$406K – – –
SFFS
10
Stonehage Fleming Financial Services
Jersey
$354K – – –
PAM
11
PVG Asset Management
Colorado
$302K +$179K +45,830 New
SF
12
Summit Financial
New Jersey
$234K +$40.5K +10,392 +41%
1WA
13
180 Wealth Advisors
Washington
$210K -$42.3K -10,850 -25%
AI
14
Atria Investments
North Carolina
$190K -$36.3K -9,305 -24%
Cetera Investment Advisers
15
Cetera Investment Advisers
Illinois
$147K -$12K -3,075 -12%
SVWAG
16
Sound View Wealth Advisors Group
Georgia
$132K – – –
Jane Street
17
Jane Street
New York
$127K +$74.9K +19,203 New
JGC
18
J. Goldman & Co
New York
$125K – – –
TP
19
TritonPoint Partners
Maryland
$99.6K +$59K +15,119 New
Millennium Management
20
Millennium Management
New York
$97.9K -$76.2K -19,533 -57%
First Manhattan
21
First Manhattan
New York
$87.2K – – –
Northern Trust
22
Northern Trust
Illinois
$82.6K +$48.9K +12,530 New
Rockefeller Capital Management
23
Rockefeller Capital Management
New York
$65.9K – – –
Bank of America
24
Bank of America
North Carolina
$59.5K -$20 -5 -0.1%
UBS Group
25
UBS Group
Switzerland
$7.25K +$4.22K +1,083 +6,371%
1
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CALC Hedge Fund Activity: Q4 2025 in Review

30 of the 8,223 institutional investors tracked by Wall St. Rank reported a position in CalciMedica (CALC) for Q4 2025, worth a combined $24.1M — up 120% from $10.9M a quarter earlier.

Fund positioning in CALC was balanced in Q4 2025: 6 funds opened new positions, 6 closed out, 5 added to existing stakes and 8 trimmed.

The largest buyer was Boothbay Fund Management, opening a new position worth an estimated $300K. The largest seller was Millennium Management, cutting an estimated $76.2K.

  • 30 institutional investors held CalciMedica (CALC) as of Q4 2025, down from 31 in Q3 2025.
  • Funds reported $24.1M of CalciMedica stock for Q4 2025, up 120% quarter-over-quarter.
  • 6 funds opened new CalciMedica positions in Q4 2025 and 6 closed out, a net change of 0 holders.
  • The largest CalciMedica buyer in Q4 2025 was Boothbay Fund Management, an estimated $300K added.
  • The largest CalciMedica seller in Q4 2025 was Millennium Management, an estimated $76.2K sold.

Based on aggregated 13F filings for Q4 2025.