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Axsome Therapeutics
AXSM

352 hedge funds and large institutions have $4.37B invested in Axsome Therapeutics in 2025 Q1 according to their latest regulatory filings, with 90 funds opening new positions, 104 increasing their positions, 115 reducing their positions, and 28 closing their positions.

New
Increased
Maintained
Reduced
Closed

221% more first-time investments, than exits

New positions opened: 90 | Existing positions closed: 28

39% more capital invested

Capital invested by funds: $3.15B → $4.37B (+$1.22B)

28% more call options, than puts

Call options by funds: $111M | Put options by funds: $86.5M

21% more funds holding

Funds holding: 292 → 352 (+60)

9% more funds holding in top 10

Funds holding in top 10: 11 → 12 (+1)

0.05% more ownership

Funds ownership: 76.73% → 76.78% (+0.05%)

10% less repeat investments, than reductions

Existing positions increased: 104 | Existing positions reduced: 115

Holders
352
Holders Change
+60
Holders Change %
+20.55%
% of All Funds
4.72%
Holding in Top 10
12
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+9.09%
% of All Funds
0.16%
New
90
Increased
104
Reduced
115
Closed
28
Calls
$111M
Puts
$86.5M
Net Calls
+$24.5M
Net Calls Change
-$35M

Top Buyers

1
Assenagon Asset Management
Assenagon Asset Management
Luxembourg
+$71.1M
2
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$60.1M
3
O
OrbiMed
New York
+$44.1M
4
1832 Asset Management
1832 Asset Management
Ontario, Canada
+$41.4M
5
Man Group
Man Group
United Kingdom
+$39.9M

Top Sellers

1
RI
RTW Investments
New York
-$129M
2
RCM
RA Capital Management
Massachusetts
-$84.6M
3
FFM
Fairmount Funds Management
Pennsylvania
-$74.5M
4
Lazard Asset Management
Lazard Asset Management
New York
-$57.9M
5
HRCM
Hood River Capital Management
Florida
-$54.6M
Name Holding Trade Value Shares
Change 		Change in
Stake
CF
151
Corebridge Financial
Texas
$2.1M -$30.4K -267 -1%
Creative Planning
152
Creative Planning
Kansas
$2.03M +$587K +5,149 +42%
TIP
153
Torray Investment Partners
Maryland
$2M -$6.61K -58 -0.3%
SCM
154
Soleus Capital Management
Connecticut
$1.98M +$1.94M +17,000 New
PFC
155
Phocas Financial Corp
California
$1.93M -$109K -958 -5%
Ameriprise
156
Ameriprise
Minnesota
$1.87M -$253K -2,222 -12%
KOCAA
157
Knights of Columbus Asset Advisors
Connecticut
$1.86M -$565K -4,957 -24%
PE
158
Point72 Europe
United Kingdom
$1.76M -$3.04M -26,684 -64%
Ensign Peak Advisors
159
Ensign Peak Advisors
Utah
$1.75M +$45.6K +400 +3%
Janney Montgomery Scott
160
Janney Montgomery Scott
Pennsylvania
$1.74M +$134K +1,178 +9%
State of New Jersey Common Pension Fund D
161
State of New Jersey Common Pension Fund D
New Jersey
$1.73M -$819K -7,191 -33%
Mariner
162
Mariner
Kansas
$1.72M -$39.8K -349 -2%
Janus Henderson Group
163
Janus Henderson Group
United Kingdom
$1.66M – – –
QC
164
Quadrature Capital
United Kingdom
$1.65M +$1.61M +14,153 New
FRM
165
Fox Run Management
Connecticut
$1.58M +$850K +7,465 +122%
HighTower Advisors
166
HighTower Advisors
Illinois
$1.58M +$10.3K +90 +0.7%
WB
167
WesBanco Bank
West Virginia
$1.55M – – –
Capital Fund Management (CFM)
168
Capital Fund Management (CFM)
France
$1.52M +$1.48M +13,025 New
ORI
169
Oak Ridge Investments
Illinois
$1.51M -$2.62K -23 -0.2%
YIH
170
Y-Intercept (HK)
Hong Kong
$1.49M +$1.45M +12,745 New
Handelsbanken Fonder
171
Handelsbanken Fonder
Sweden
$1.38M – – –
CIBC Private Wealth Group
172
CIBC Private Wealth Group
Georgia
$1.34M -$285K -2,499 -15%
DIA
173
Dana Investment Advisors
Wisconsin
$1.32M -$579K -5,081 -31%
EAM
174
Erste Asset Management
Austria
$1.3M – – –
SO
175
STRS Ohio
Ohio
$1.21M +$661K +5,800 +126%
5 6
7
8 9

AXSM Hedge Fund Activity: Q1 2025 in Review

352 of the 7,457 institutional investors tracked by Wall St. Rank reported a position in Axsome Therapeutics (AXSM) for Q1 2025, worth a combined $4.37B — up 39% from $3.15B a quarter earlier.

Buyers outnumbered sellers: 90 funds opened new AXSM positions and 28 closed out — a net gain of 62 holders — while 104 added to existing stakes and 115 trimmed.

The largest buyer was Assenagon Asset Management, adding an estimated $71.1M. The largest seller was RTW Investments, cutting an estimated $129M.

  • 352 institutional investors held Axsome Therapeutics (AXSM) as of Q1 2025, up from 292 in Q4 2024.
  • Funds reported $4.37B of Axsome Therapeutics stock for Q1 2025, up 39% quarter-over-quarter.
  • 90 funds opened new Axsome Therapeutics positions in Q1 2025 and 28 closed out, a net change of +62 holders.
  • The largest Axsome Therapeutics buyer in Q1 2025 was Assenagon Asset Management, an estimated $71.1M added.
  • The largest Axsome Therapeutics seller in Q1 2025 was RTW Investments, an estimated $129M sold.

Based on aggregated 13F filings for Q1 2025.