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Axsome Therapeutics
AXSM

352 hedge funds and large institutions have $4.37B invested in Axsome Therapeutics in 2025 Q1 according to their latest regulatory filings, with 90 funds opening new positions, 104 increasing their positions, 115 reducing their positions, and 28 closing their positions.

New
Increased
Maintained
Reduced
Closed

221% more first-time investments, than exits

New positions opened: 90 | Existing positions closed: 28

39% more capital invested

Capital invested by funds: $3.15B → $4.37B (+$1.22B)

28% more call options, than puts

Call options by funds: $111M | Put options by funds: $86.5M

21% more funds holding

Funds holding: 292 → 352 (+60)

9% more funds holding in top 10

Funds holding in top 10: 11 → 12 (+1)

0.05% more ownership

Funds ownership: 76.73% → 76.78% (+0.05%)

10% less repeat investments, than reductions

Existing positions increased: 104 | Existing positions reduced: 115

Holders
352
Holders Change
+60
Holders Change %
+20.55%
% of All Funds
4.72%
Holding in Top 10
12
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+9.09%
% of All Funds
0.16%
New
90
Increased
104
Reduced
115
Closed
28
Calls
$111M
Puts
$86.5M
Net Calls
+$24.5M
Net Calls Change
-$35M

Top Buyers

1
Assenagon Asset Management
Assenagon Asset Management
Luxembourg
+$71.1M
2
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$60.1M
3
O
OrbiMed
New York
+$44.1M
4
1832 Asset Management
1832 Asset Management
Ontario, Canada
+$41.4M
5
Man Group
Man Group
United Kingdom
+$39.9M

Top Sellers

1
RI
RTW Investments
New York
-$129M
2
RCM
RA Capital Management
Massachusetts
-$84.6M
3
FFM
Fairmount Funds Management
Pennsylvania
-$74.5M
4
Lazard Asset Management
Lazard Asset Management
New York
-$57.9M
5
HRCM
Hood River Capital Management
Florida
-$54.6M
Name Holding Trade Value Shares
Change 		Change in
Stake
ClearBridge Investments
76
ClearBridge Investments
New York
$7.95M -$5.12M -44,913 -40%
IA
77
IFP Advisors
Florida
$7.94M +$31.3K +275 +0.4%
Aberdeen Group
78
Aberdeen Group
United Kingdom
$7.46M -$937K -8,225 -11%
VanEck Associates
79
VanEck Associates
New York
$7.35M +$7.18M +62,995 New
MAP
80
Moody Aldrich Partners
Massachusetts
$7.27M +$1.96M +17,201 +38%
DnB Asset Management
81
DnB Asset Management
Norway
$7.18M -$1.39M -12,242 -17%
AllianceBernstein
82
AllianceBernstein
Tennessee
$7.17M +$1.7M +14,881 +32%
Swiss National Bank
83
Swiss National Bank
Switzerland
$7.11M -$45.6K -400 -0.7%
PCM
84
Peregrine Capital Management
Minnesota
$6.97M -$3.13M -27,466 -32%
RAM
85
Readystate Asset Management
Illinois
$6.95M +$6.78M +59,553 New
HWAM
86
Hennion & Walsh Asset Management
New Jersey
$6.91M +$164K +1,437 +2%
AQR Capital Management
87
AQR Capital Management
Connecticut
$6.81M +$2.3M +20,152 +53%
HWM
88
HB Wealth Management
Georgia
$6.42M +$6.27M +55,030 New
RhumbLine Advisers
89
RhumbLine Advisers
Massachusetts
$6.39M +$400K +3,515 +7%
PFM
90
Privium Fund Management
Netherlands
$6.15M -$1.08M -9,500 -15%
ECM
91
ExodusPoint Capital Management
New York
$6.14M +$6M +52,683 New
William Blair & Company
92
William Blair & Company
Illinois
$6.13M -$211K -1,853 -3%
Barclays
93
Barclays
United Kingdom
$6.05M -$5.25M -46,118 -47%
Susquehanna International Group
94
Susquehanna International Group
Pennsylvania
$6.03M +$3.75M +32,956 +176%
PP
95
PDT Partners
New York
$5.97M +$5.35M +47,004 +1,120%
Universal-Beteiligungs- und Servicegesellschaft
96
Universal-Beteiligungs- und Servicegesellschaft
Germany
$5.84M +$5.71M +50,096 New
BWP
97
Baldwin Wealth Partners
Massachusetts
$5.78M – – –
LC
98
Lindbrook Capital
California
$5.6M -$1.61M -14,103 -23%
Adage Capital Partners
99
Adage Capital Partners
Massachusetts
$5.6M -$1.37M -12,000 -20%
ACM
100
Aquatic Capital Management
Illinois
$5.53M +$5.3M +46,543 +5,154%
2 3
4
5 6

AXSM Hedge Fund Activity: Q1 2025 in Review

352 of the 7,457 institutional investors tracked by Wall St. Rank reported a position in Axsome Therapeutics (AXSM) for Q1 2025, worth a combined $4.37B — up 39% from $3.15B a quarter earlier.

Buyers outnumbered sellers: 90 funds opened new AXSM positions and 28 closed out — a net gain of 62 holders — while 104 added to existing stakes and 115 trimmed.

The largest buyer was Assenagon Asset Management, adding an estimated $71.1M. The largest seller was RTW Investments, cutting an estimated $129M.

  • 352 institutional investors held Axsome Therapeutics (AXSM) as of Q1 2025, up from 292 in Q4 2024.
  • Funds reported $4.37B of Axsome Therapeutics stock for Q1 2025, up 39% quarter-over-quarter.
  • 90 funds opened new Axsome Therapeutics positions in Q1 2025 and 28 closed out, a net change of +62 holders.
  • The largest Axsome Therapeutics buyer in Q1 2025 was Assenagon Asset Management, an estimated $71.1M added.
  • The largest Axsome Therapeutics seller in Q1 2025 was RTW Investments, an estimated $129M sold.

Based on aggregated 13F filings for Q1 2025.