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Axsome Therapeutics
AXSM

352 hedge funds and large institutions have $4.37B invested in Axsome Therapeutics in 2025 Q1 according to their latest regulatory filings, with 90 funds opening new positions, 104 increasing their positions, 115 reducing their positions, and 28 closing their positions.

New
Increased
Maintained
Reduced
Closed

221% more first-time investments, than exits

New positions opened: 90 | Existing positions closed: 28

39% more capital invested

Capital invested by funds: $3.15B → $4.37B (+$1.22B)

28% more call options, than puts

Call options by funds: $111M | Put options by funds: $86.5M

21% more funds holding

Funds holding: 292 → 352 (+60)

9% more funds holding in top 10

Funds holding in top 10: 11 → 12 (+1)

0.05% more ownership

Funds ownership: 76.73% → 76.78% (+0.05%)

10% less repeat investments, than reductions

Existing positions increased: 104 | Existing positions reduced: 115

Holders
352
Holders Change
+60
Holders Change %
+20.55%
% of All Funds
4.72%
Holding in Top 10
12
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+9.09%
% of All Funds
0.16%
New
90
Increased
104
Reduced
115
Closed
28
Calls
$111M
Puts
$86.5M
Net Calls
+$24.5M
Net Calls Change
-$35M

Top Buyers

1
Assenagon Asset Management
Assenagon Asset Management
Luxembourg
+$71.1M
2
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$60.1M
3
O
OrbiMed
New York
+$44.1M
4
1832 Asset Management
1832 Asset Management
Ontario, Canada
+$41.4M
5
Man Group
Man Group
United Kingdom
+$39.9M

Top Sellers

1
RI
RTW Investments
New York
-$129M
2
RCM
RA Capital Management
Massachusetts
-$84.6M
3
FFM
Fairmount Funds Management
Pennsylvania
-$74.5M
4
Lazard Asset Management
Lazard Asset Management
New York
-$57.9M
5
HRCM
Hood River Capital Management
Florida
-$54.6M
Name Holding Trade Value Shares
Change 		Change in
Stake
Bank of New York Mellon
51
Bank of New York Mellon
New York
$15.3M -$402K -3,527 -3%
US Bancorp
52
US Bancorp
Minnesota
$15.2M -$82.5K -724 -0.6%
Point72 Asset Management
53
Point72 Asset Management
Connecticut
$14.7M -$6.72M -58,945 -32%
JP Morgan Chase
54
JP Morgan Chase
New York
$14.6M -$8.79M -77,119 -38%
FTM
55
First Turn Management
California
$13.8M -$8.43M -73,967 -38%
WCM Investment Management
56
WCM Investment Management
California
$13.3M -$5.47K -48 -0%
RPAM
57
Rhenman & Partners Asset Management
Sweden
$12.8M -$1.48M -13,000 -11%
IAM
58
Iridian Asset Management
Connecticut
$12.4M -$2.14M -18,767 -15%
TLP
59
Tri Locum Partners
New York
$11.8M -$16.9M -148,529 -59%
AAA
60
Affinity Asset Advisors
New York
$11.7M +$2.85M +25,000 +33%
VOYA Investment Management
61
VOYA Investment Management
Georgia
$11.5M -$426K -3,742 -4%
BG
62
Bellevue Group
Switzerland
$11.2M -$2.57M -22,523 -19%
Deutsche Bank
63
Deutsche Bank
Germany
$11.1M -$2.91M -25,567 -21%
JF
64
Jump Financial
Illinois
$10.8M +$10.6M +92,640 New
Jane Street
65
Jane Street
New York
$10.5M +$1.33M +11,692 +15%
CS
66
Cannell & Spears
New York
$9.83M +$248K +2,177 +3%
Citadel Advisors
67
Citadel Advisors
Florida
$9.77M -$46.9M -411,603 -83%
HSBC Holdings
68
HSBC Holdings
United Kingdom
$9.74M -$6.06M -53,213 -39%
CS
69
Candriam SCA
Luxembourg
$9.32M +$9.11M +79,930 New
APM
70
Avidity Partners Management
Texas
$8.98M -$12.6M -111,000 -59%
UBS AM
71
UBS AM
Illinois
$8.73M +$1.97M +17,250 +30%
ACM
72
Atika Capital Management
New York
$8.6M +$5.89M +51,700 +235%
ABG
73
Ally Bridge Group
New York
$8.41M +$621K +5,452 +8%
EP
74
Edgestream Partners
New Jersey
$8.17M +$7.98M +70,086 New
Marshall Wace
75
Marshall Wace
United Kingdom
$8.01M -$6.65M -58,401 -46%
1 2
3
4 5

AXSM Hedge Fund Activity: Q1 2025 in Review

352 of the 7,457 institutional investors tracked by Wall St. Rank reported a position in Axsome Therapeutics (AXSM) for Q1 2025, worth a combined $4.37B — up 39% from $3.15B a quarter earlier.

Buyers outnumbered sellers: 90 funds opened new AXSM positions and 28 closed out — a net gain of 62 holders — while 104 added to existing stakes and 115 trimmed.

The largest buyer was Assenagon Asset Management, adding an estimated $71.1M. The largest seller was RTW Investments, cutting an estimated $129M.

  • 352 institutional investors held Axsome Therapeutics (AXSM) as of Q1 2025, up from 292 in Q4 2024.
  • Funds reported $4.37B of Axsome Therapeutics stock for Q1 2025, up 39% quarter-over-quarter.
  • 90 funds opened new Axsome Therapeutics positions in Q1 2025 and 28 closed out, a net change of +62 holders.
  • The largest Axsome Therapeutics buyer in Q1 2025 was Assenagon Asset Management, an estimated $71.1M added.
  • The largest Axsome Therapeutics seller in Q1 2025 was RTW Investments, an estimated $129M sold.

Based on aggregated 13F filings for Q1 2025.