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Axsome Therapeutics
AXSM

352 hedge funds and large institutions have $4.37B invested in Axsome Therapeutics in 2025 Q1 according to their latest regulatory filings, with 90 funds opening new positions, 104 increasing their positions, 115 reducing their positions, and 28 closing their positions.

New
Increased
Maintained
Reduced
Closed

221% more first-time investments, than exits

New positions opened: 90 | Existing positions closed: 28

39% more capital invested

Capital invested by funds: $3.15B → $4.37B (+$1.22B)

28% more call options, than puts

Call options by funds: $111M | Put options by funds: $86.5M

21% more funds holding

Funds holding: 292 → 352 (+60)

9% more funds holding in top 10

Funds holding in top 10: 11 → 12 (+1)

0.05% more ownership

Funds ownership: 76.73% → 76.78% (+0.05%)

10% less repeat investments, than reductions

Existing positions increased: 104 | Existing positions reduced: 115

Holders
352
Holders Change
+60
Holders Change %
+20.55%
% of All Funds
4.72%
Holding in Top 10
12
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+9.09%
% of All Funds
0.16%
New
90
Increased
104
Reduced
115
Closed
28
Calls
$111M
Puts
$86.5M
Net Calls
+$24.5M
Net Calls Change
-$35M

Top Buyers

1
Assenagon Asset Management
Assenagon Asset Management
Luxembourg
+$71.1M
2
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$60.1M
3
O
OrbiMed
New York
+$44.1M
4
1832 Asset Management
1832 Asset Management
Ontario, Canada
+$41.4M
5
Man Group
Man Group
United Kingdom
+$39.9M

Top Sellers

1
RI
RTW Investments
New York
-$129M
2
RCM
RA Capital Management
Massachusetts
-$84.6M
3
FFM
Fairmount Funds Management
Pennsylvania
-$74.5M
4
Lazard Asset Management
Lazard Asset Management
New York
-$57.9M
5
HRCM
Hood River Capital Management
Florida
-$54.6M
Name Holding Trade Value Shares
Change 		Change in
Stake
SPIA
351
Steward Partners Investment Advisory
New York
$467 – – –
LFG
352
Larson Financial Group
Missouri
$117 +$114 +1 New
RCM
353
RA Capital Management
Massachusetts
– -$84.6M -1,000,000 Closed
HRCM
354
Hood River Capital Management
Florida
– -$54.6M -644,785 Closed
BCM
355
Boxer Capital Management
California
– -$39.8M -470,000 Closed
CC
356
Checkpoint Capital
California
– -$14.8M -174,769 Closed
CM
357
Caption Management
Oklahoma
– -$13.2M -115,686 Closed
MB
358
MPM BioImpact
Massachusetts
– -$4.23M -50,000 Closed
JFG
359
Jefferies Financial Group
New York
– -$3.44M -40,700 Closed
BHCM
360
Brevan Howard Capital Management
Jersey
– -$3.28M -38,748 Closed
ACM
361
ADAR1 Capital Management
Texas
– -$1.66M -19,661 Closed
TI
362
Trexquant Investment
Connecticut
– -$1.2M -14,129 Closed
Calamos Advisors
363
Calamos Advisors
Illinois
– -$1.08M -12,808 Closed
Hudson Bay Capital Management
364
Hudson Bay Capital Management
Connecticut
– -$1.06M -12,500 Closed
1CM
365
1492 Capital Management
Wisconsin
– -$963K -11,385 Closed
BC
366
Bridgefront Capital
Texas
– -$893K -10,555 Closed
PTC
367
Petrus Trust Company
Texas
– -$742K -8,764 Closed
SCM
368
Superstring Capital Management
New York
– -$361K -4,268 Closed
SPA
369
Sherbrooke Park Advisers
New York
– -$345K -4,082 Closed
SSWG
370
Seven Springs Wealth Group
Tennessee
– -$339K -4,005 Closed
VEA
371
Virtus ETF Advisers
New York
– -$313K -3,705 Closed
1C
372
111 Capital
France
– -$278K -3,291 Closed
FCC
373
Flower City Capital
New York
– -$254K -3,000 Closed
Simplex Trading
374
Simplex Trading
Illinois
– -$335K -2,942 Closed
Corient Private Wealth
375
Corient Private Wealth
Florida
– -$239K -2,829 Closed
12 13 14
15
16

AXSM Hedge Fund Activity: Q1 2025 in Review

352 of the 7,457 institutional investors tracked by Wall St. Rank reported a position in Axsome Therapeutics (AXSM) for Q1 2025, worth a combined $4.37B — up 39% from $3.15B a quarter earlier.

Buyers outnumbered sellers: 90 funds opened new AXSM positions and 28 closed out — a net gain of 62 holders — while 104 added to existing stakes and 115 trimmed.

The largest buyer was Assenagon Asset Management, adding an estimated $71.1M. The largest seller was RTW Investments, cutting an estimated $129M.

  • 352 institutional investors held Axsome Therapeutics (AXSM) as of Q1 2025, up from 292 in Q4 2024.
  • Funds reported $4.37B of Axsome Therapeutics stock for Q1 2025, up 39% quarter-over-quarter.
  • 90 funds opened new Axsome Therapeutics positions in Q1 2025 and 28 closed out, a net change of +62 holders.
  • The largest Axsome Therapeutics buyer in Q1 2025 was Assenagon Asset Management, an estimated $71.1M added.
  • The largest Axsome Therapeutics seller in Q1 2025 was RTW Investments, an estimated $129M sold.

Based on aggregated 13F filings for Q1 2025.