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Axsome Therapeutics
AXSM

352 hedge funds and large institutions have $4.37B invested in Axsome Therapeutics in 2025 Q1 according to their latest regulatory filings, with 90 funds opening new positions, 104 increasing their positions, 115 reducing their positions, and 28 closing their positions.

New
Increased
Maintained
Reduced
Closed

221% more first-time investments, than exits

New positions opened: 90 | Existing positions closed: 28

39% more capital invested

Capital invested by funds: $3.15B → $4.37B (+$1.22B)

28% more call options, than puts

Call options by funds: $111M | Put options by funds: $86.5M

21% more funds holding

Funds holding: 292 → 352 (+60)

9% more funds holding in top 10

Funds holding in top 10: 11 → 12 (+1)

0.05% more ownership

Funds ownership: 76.73% → 76.78% (+0.05%)

10% less repeat investments, than reductions

Existing positions increased: 104 | Existing positions reduced: 115

Holders
352
Holders Change
+60
Holders Change %
+20.55%
% of All Funds
4.72%
Holding in Top 10
12
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+9.09%
% of All Funds
0.16%
New
90
Increased
104
Reduced
115
Closed
28
Calls
$111M
Puts
$86.5M
Net Calls
+$24.5M
Net Calls Change
-$35M

Top Buyers

1
Assenagon Asset Management
Assenagon Asset Management
Luxembourg
+$71.1M
2
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$60.1M
3
O
OrbiMed
New York
+$44.1M
4
1832 Asset Management
1832 Asset Management
Ontario, Canada
+$41.4M
5
Man Group
Man Group
United Kingdom
+$39.9M

Top Sellers

1
RI
RTW Investments
New York
-$129M
2
RCM
RA Capital Management
Massachusetts
-$84.6M
3
FFM
Fairmount Funds Management
Pennsylvania
-$74.5M
4
Lazard Asset Management
Lazard Asset Management
New York
-$57.9M
5
HRCM
Hood River Capital Management
Florida
-$54.6M
Name Holding Trade Value Shares
Change 		Change in
Stake
PA
326
PSI Advisors
Florida
$4.67K – – –
SCM
327
Sterling Capital Management
North Carolina
$4.43K +$114 +1 +3%
FFA
328
Farther Finance Advisors
California
$4.36K -$342 -3 -7%
BIG
329
Brooklyn Investment Group
New York
$3.62K +$1.25K +11 +55%
SS
330
SBI Securities
Japan
$3.38K -$3.42K -30 -51%
TWD
331
True Wealth Design
Ohio
$3.03K +$1.82K +16 +160%
Bessemer Group
332
Bessemer Group
New Jersey
$3K -$570 -5 -17%
RS
333
Rakuten Securities
Japan
$2.92K +$2.85K +25 New
GWSG
334
GPS Wealth Strategies Group
Colorado
$2.1K – – –
BIA
335
Bell Investment Advisors
California
$1.87K – – –
PFBT
336
Parkside Financial Bank & Trust
Missouri
$1.75K +$1.71K +15 New
PA
337
Parallel Advisors
California
$1.75K +$342 +3 +25%
MAM
338
Meeder Asset Management
Ohio
$1.63K +$1.59K +14 New
TPCW
339
TD Private Client Wealth
New York
$1.63K +$1.59K +14 New
HCP
340
Hexagon Capital Partners
Arkansas
$1.52K – – –
NSIM
341
North Star Investment Management
Illinois
$1.52K – – –
FHA
342
First Horizon Advisors
Tennessee
$1.28K -$570 -5 -31%
PWA
343
Physician Wealth Advisors
Utah
$1.17K – – –
WWM
344
Wolff Wiese Magana
California
$1.17K – – –
SC
345
Stephens Consulting
Michigan
$1.17K +$1.14K +10 New
CFD
346
Creative Financial Designs
Indiana
$1.17K +$1.14K +10 New
SW
347
SVB Wealth
Massachusetts
$1.17K +$1.14K +10 New
WSFS
348
Wilmington Savings Fund Society
Delaware
$1.05K +$1.02K +9 New
PS
349
Principal Securities
Iowa
$677 – – –
CPG
350
Cornerstone Planning Group
New Jersey
$521 – – –
12 13
14
15 16

AXSM Hedge Fund Activity: Q1 2025 in Review

352 of the 7,457 institutional investors tracked by Wall St. Rank reported a position in Axsome Therapeutics (AXSM) for Q1 2025, worth a combined $4.37B — up 39% from $3.15B a quarter earlier.

Buyers outnumbered sellers: 90 funds opened new AXSM positions and 28 closed out — a net gain of 62 holders — while 104 added to existing stakes and 115 trimmed.

The largest buyer was Assenagon Asset Management, adding an estimated $71.1M. The largest seller was RTW Investments, cutting an estimated $129M.

  • 352 institutional investors held Axsome Therapeutics (AXSM) as of Q1 2025, up from 292 in Q4 2024.
  • Funds reported $4.37B of Axsome Therapeutics stock for Q1 2025, up 39% quarter-over-quarter.
  • 90 funds opened new Axsome Therapeutics positions in Q1 2025 and 28 closed out, a net change of +62 holders.
  • The largest Axsome Therapeutics buyer in Q1 2025 was Assenagon Asset Management, an estimated $71.1M added.
  • The largest Axsome Therapeutics seller in Q1 2025 was RTW Investments, an estimated $129M sold.

Based on aggregated 13F filings for Q1 2025.