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Axsome Therapeutics
AXSM

352 hedge funds and large institutions have $4.37B invested in Axsome Therapeutics in 2025 Q1 according to their latest regulatory filings, with 90 funds opening new positions, 104 increasing their positions, 115 reducing their positions, and 28 closing their positions.

New
Increased
Maintained
Reduced
Closed

221% more first-time investments, than exits

New positions opened: 90 | Existing positions closed: 28

39% more capital invested

Capital invested by funds: $3.15B → $4.37B (+$1.22B)

28% more call options, than puts

Call options by funds: $111M | Put options by funds: $86.5M

21% more funds holding

Funds holding: 292 → 352 (+60)

9% more funds holding in top 10

Funds holding in top 10: 11 → 12 (+1)

0.05% more ownership

Funds ownership: 76.73% → 76.78% (+0.05%)

10% less repeat investments, than reductions

Existing positions increased: 104 | Existing positions reduced: 115

Holders
352
Holders Change
+60
Holders Change %
+20.55%
% of All Funds
4.72%
Holding in Top 10
12
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+9.09%
% of All Funds
0.16%
New
90
Increased
104
Reduced
115
Closed
28
Calls
$111M
Puts
$86.5M
Net Calls
+$24.5M
Net Calls Change
-$35M

Top Buyers

1
Assenagon Asset Management
Assenagon Asset Management
Luxembourg
+$71.1M
2
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$60.1M
3
O
OrbiMed
New York
+$44.1M
4
1832 Asset Management
1832 Asset Management
Ontario, Canada
+$41.4M
5
Man Group
Man Group
United Kingdom
+$39.9M

Top Sellers

1
RI
RTW Investments
New York
-$129M
2
RCM
RA Capital Management
Massachusetts
-$84.6M
3
FFM
Fairmount Funds Management
Pennsylvania
-$74.5M
4
Lazard Asset Management
Lazard Asset Management
New York
-$57.9M
5
HRCM
Hood River Capital Management
Florida
-$54.6M
Name Holding Trade Value Shares
Change 		Change in
Stake
EWA
301
EverSource Wealth Advisors
Alabama
$30.2K +$9.23K +81 +46%
WTA
302
Washington Trust Advisors
Massachusetts
$29.2K -$9.11K -80 -24%
CIAM
303
Caitong International Asset Management
Hong Kong
$25K +$24.4K +214 New
Fifth Third Bancorp
304
Fifth Third Bancorp
Ohio
$23.3K – – –
SAM
305
Smartleaf Asset Management
Massachusetts
$22.4K +$797 +7 +4%
GI
306
GAMMA Investing
California
$22K +$15K +132 +232%
HNB
307
Huntington National Bank
Ohio
$21.6K -$3.3K -29 -14%
Daiwa Securities Group
308
Daiwa Securities Group
Japan
$19K – – –
T
309
Transce3nd
Texas
$17.5K +$1.82K +16 +12%
MPWT
310
MassMutual Private Wealth & Trust
Connecticut
$16.1K +$15K +132 +2,200%
QCG
311
Quadrant Capital Group
Ohio
$15.7K – – –
C
312
Covestor
United Kingdom
$15K +$114 +1 +0.8%
CCM
313
Coldstream Capital Management
Washington
$14K +$13.7K +120 New
UB
314
UMB Bank
Missouri
$13.8K – – –
BTI
315
Blue Trust Inc
Georgia
$13.2K – – –
HCM
316
Hollencrest Capital Management
California
$10.1K +$9.91K +87 New
RA
317
Rise Advisors
New York
$9.33K +$9.11K +80 New
GWM
318
Geneos Wealth Management
Colorado
$7.93K +$1.82K +16 +70%
AAP
319
Arax Advisory Partners
Colorado
$7.81K +$5.58K +49 +272%
WA
320
WPG Advisers
Maryland
$7.11K +$2.39K +21 +53%
RIL
321
Rothschild Investment LLC
Illinois
$7K +$2.85K +25 +71%
HI
322
Harbour Investments
Wisconsin
$7K +$4.1K +36 +150%
Optiver Holding
323
Optiver Holding
Netherlands
$7K +$6.84K +60 New
OCM
324
Orion Capital Management
California
$5.83K – – –
PTC
325
Private Trust Company
Ohio
$4.78K -$911 -8 -16%
11 12
13
14 15

AXSM Hedge Fund Activity: Q1 2025 in Review

352 of the 7,457 institutional investors tracked by Wall St. Rank reported a position in Axsome Therapeutics (AXSM) for Q1 2025, worth a combined $4.37B — up 39% from $3.15B a quarter earlier.

Buyers outnumbered sellers: 90 funds opened new AXSM positions and 28 closed out — a net gain of 62 holders — while 104 added to existing stakes and 115 trimmed.

The largest buyer was Assenagon Asset Management, adding an estimated $71.1M. The largest seller was RTW Investments, cutting an estimated $129M.

  • 352 institutional investors held Axsome Therapeutics (AXSM) as of Q1 2025, up from 292 in Q4 2024.
  • Funds reported $4.37B of Axsome Therapeutics stock for Q1 2025, up 39% quarter-over-quarter.
  • 90 funds opened new Axsome Therapeutics positions in Q1 2025 and 28 closed out, a net change of +62 holders.
  • The largest Axsome Therapeutics buyer in Q1 2025 was Assenagon Asset Management, an estimated $71.1M added.
  • The largest Axsome Therapeutics seller in Q1 2025 was RTW Investments, an estimated $129M sold.

Based on aggregated 13F filings for Q1 2025.