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Axsome Therapeutics
AXSM

352 hedge funds and large institutions have $4.37B invested in Axsome Therapeutics in 2025 Q1 according to their latest regulatory filings, with 90 funds opening new positions, 104 increasing their positions, 115 reducing their positions, and 28 closing their positions.

New
Increased
Maintained
Reduced
Closed

221% more first-time investments, than exits

New positions opened: 90 | Existing positions closed: 28

39% more capital invested

Capital invested by funds: $3.15B → $4.37B (+$1.22B)

28% more call options, than puts

Call options by funds: $111M | Put options by funds: $86.5M

21% more funds holding

Funds holding: 292 → 352 (+60)

9% more funds holding in top 10

Funds holding in top 10: 11 → 12 (+1)

0.05% more ownership

Funds ownership: 76.73% → 76.78% (+0.05%)

10% less repeat investments, than reductions

Existing positions increased: 104 | Existing positions reduced: 115

Holders
352
Holders Change
+60
Holders Change %
+20.55%
% of All Funds
4.72%
Holding in Top 10
12
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+9.09%
% of All Funds
0.16%
New
90
Increased
104
Reduced
115
Closed
28
Calls
$111M
Puts
$86.5M
Net Calls
+$24.5M
Net Calls Change
-$35M

Top Buyers

1
Assenagon Asset Management
Assenagon Asset Management
Luxembourg
+$71.1M
2
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$60.1M
3
O
OrbiMed
New York
+$44.1M
4
1832 Asset Management
1832 Asset Management
Ontario, Canada
+$41.4M
5
Man Group
Man Group
United Kingdom
+$39.9M

Top Sellers

1
RI
RTW Investments
New York
-$129M
2
RCM
RA Capital Management
Massachusetts
-$84.6M
3
FFM
Fairmount Funds Management
Pennsylvania
-$74.5M
4
Lazard Asset Management
Lazard Asset Management
New York
-$57.9M
5
HRCM
Hood River Capital Management
Florida
-$54.6M
Name Holding Trade Value Shares
Change 		Change in
Stake
KBC Group
276
KBC Group
Belgium
$166K +$9.57K +84 +6%
QL
277
Quarry LP
New York
$163K +$74.1K +650 +87%
Osaic Holdings
278
Osaic Holdings
Arizona
$158K -$131K -1,151 -46%
AB
279
Amalgamated Bank
New York
$148K +$1.94K +17 +1%
GFM
280
GF Fund Management
China
$145K +$25.4K +223 +22%
CA
281
Clearstead Advisors
Ohio
$132K -$28.5K -250 -18%
Nisa Investment Advisors
282
Nisa Investment Advisors
Missouri
$122K -$2.96K -26 -2%
SAM
283
Sectoral Asset Management
Quebec, Canada
$119K +$22.8K +200 +24%
Twin Tree Management
284
Twin Tree Management
Texas
$116K +$114K +997 New
AssetMark Inc
285
AssetMark Inc
California
$115K +$42.8K +376 +62%
TRCT
286
Tower Research Capital (TRC)
New York
$102K -$421K -3,692 -81%
RBI
287
Raiffeisen Bank International
Austria
$70K – – –
KFI
288
Key Financial Inc
Pennsylvania
$52.5K – – –
BAMF
289
BI Asset Management Fondsmaeglerselskab
Denmark
$47K +$46K +404 New
TCOV
290
Trust Company of Vermont
Vermont
$46.7K -$11.4K -100 -20%
Northwestern Mutual Wealth Management
291
Northwestern Mutual Wealth Management
Wisconsin
$44.6K – – –
NICM
292
Neo Ivy Capital Management
New York
$40.8K +$39.9K +350 New
S
293
SignatureFD
Georgia
$38.4K – – –
A
294
AlphaQuest
New York
$38.3K +$37.4K +328 New
Jones Financial Companies
295
Jones Financial Companies
Missouri
$36K – – –
AAG
296
Armstrong Advisory Group
Massachusetts
$35.8K – – –
MCM
297
MAI Capital Management
Ohio
$33.9K – – –
NS
298
NBC Securities
Alabama
$31K +$31.1K +273 New
AF
299
Allworth Financial
California
$30.9K +$684 +6 +2%
QT
300
Quantbot Technologies
New York
$30.8K +$30.1K +264 New
10 11
12
13 14

AXSM Hedge Fund Activity: Q1 2025 in Review

352 of the 7,457 institutional investors tracked by Wall St. Rank reported a position in Axsome Therapeutics (AXSM) for Q1 2025, worth a combined $4.37B — up 39% from $3.15B a quarter earlier.

Buyers outnumbered sellers: 90 funds opened new AXSM positions and 28 closed out — a net gain of 62 holders — while 104 added to existing stakes and 115 trimmed.

The largest buyer was Assenagon Asset Management, adding an estimated $71.1M. The largest seller was RTW Investments, cutting an estimated $129M.

  • 352 institutional investors held Axsome Therapeutics (AXSM) as of Q1 2025, up from 292 in Q4 2024.
  • Funds reported $4.37B of Axsome Therapeutics stock for Q1 2025, up 39% quarter-over-quarter.
  • 90 funds opened new Axsome Therapeutics positions in Q1 2025 and 28 closed out, a net change of +62 holders.
  • The largest Axsome Therapeutics buyer in Q1 2025 was Assenagon Asset Management, an estimated $71.1M added.
  • The largest Axsome Therapeutics seller in Q1 2025 was RTW Investments, an estimated $129M sold.

Based on aggregated 13F filings for Q1 2025.