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Axsome Therapeutics
AXSM

352 hedge funds and large institutions have $4.37B invested in Axsome Therapeutics in 2025 Q1 according to their latest regulatory filings, with 90 funds opening new positions, 104 increasing their positions, 115 reducing their positions, and 28 closing their positions.

New
Increased
Maintained
Reduced
Closed

221% more first-time investments, than exits

New positions opened: 90 | Existing positions closed: 28

39% more capital invested

Capital invested by funds: $3.15B → $4.37B (+$1.22B)

28% more call options, than puts

Call options by funds: $111M | Put options by funds: $86.5M

21% more funds holding

Funds holding: 292 → 352 (+60)

9% more funds holding in top 10

Funds holding in top 10: 11 → 12 (+1)

0.05% more ownership

Funds ownership: 76.73% → 76.78% (+0.05%)

10% less repeat investments, than reductions

Existing positions increased: 104 | Existing positions reduced: 115

Holders
352
Holders Change
+60
Holders Change %
+20.55%
% of All Funds
4.72%
Holding in Top 10
12
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+9.09%
% of All Funds
0.16%
New
90
Increased
104
Reduced
115
Closed
28
Calls
$111M
Puts
$86.5M
Net Calls
+$24.5M
Net Calls Change
-$35M

Top Buyers

1
Assenagon Asset Management
Assenagon Asset Management
Luxembourg
+$71.1M
2
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$60.1M
3
O
OrbiMed
New York
+$44.1M
4
1832 Asset Management
1832 Asset Management
Ontario, Canada
+$41.4M
5
Man Group
Man Group
United Kingdom
+$39.9M

Top Sellers

1
RI
RTW Investments
New York
-$129M
2
RCM
RA Capital Management
Massachusetts
-$84.6M
3
FFM
Fairmount Funds Management
Pennsylvania
-$74.5M
4
Lazard Asset Management
Lazard Asset Management
New York
-$57.9M
5
HRCM
Hood River Capital Management
Florida
-$54.6M
Name Holding Trade Value Shares
Change 		Change in
Stake
Russell Investments Group
251
Russell Investments Group
United Kingdom
$308K -$1.91M -16,799 -86%
CAU
252
Caxton Associates (UK)
$307K +$300K +2,629 New
Mackenzie Financial
253
Mackenzie Financial
Ontario, Canada
$273K +$266K +2,339 New
NIM
254
NEOS Investment Management
Connecticut
$271K +$265K +2,327 New
TE
255
Tema ETFs
New York
$271K +$265K +2,327 New
JGC
256
J. Goldman & Co
New York
$268K -$4.33M -38,027 -94%
BCI
257
Brinker Capital Investments
Pennsylvania
$264K +$258K +2,266 New
OPS
258
Orion Portfolio Solutions
Nebraska
$264K +$258K +2,266 New
MC
259
Moors & Cabot
Massachusetts
$260K +$254K +2,230 New
ML
260
McAdam LLC
Pennsylvania
$256K +$250K +2,194 New
SCM
261
Semanteon Capital Management
Massachusetts
$253K +$248K +2,173 New
EC
262
EntryPoint Capital
New York
$253K +$247K +2,167 New
AWM
263
Adams Wealth Management
Utah
$251K +$247K +2,169 New
CI
264
CacheTech Inc
Utah
$251K +$247K +2,169 New
Walleye Trading
265
Walleye Trading
New York
$250K +$244K +2,141 New
TIM
266
Tortoise Investment Management
New York
$249K – – –
AAS
267
Avantax Advisory Services
Texas
$246K +$240K +2,106 New
Truist Financial
268
Truist Financial
North Carolina
$239K +$233K +2,048 New
DC
269
Davenport & Co
Virginia
$218K +$213K +1,867 New
SEIA
270
Signature Estate & Investment Advisors
California
$214K -$91.1K -800 -30%
Carson Wealth (CWM LLC)
271
Carson Wealth (CWM LLC)
Nebraska
$208K -$1.93M -16,918 -90%
BHB
272
Bank Hapoalim BM
Israel
$204K +$199K +1,750 New
Los Angeles Capital Management
273
Los Angeles Capital Management
California
$203K +$198K +1,738 New
Mirae Asset Global Investments
274
Mirae Asset Global Investments
South Korea
$193K +$1.94K +17 +1%
Walleye Capital
275
Walleye Capital
New York
$185K -$43K -377 -19%
9 10
11
12 13

AXSM Hedge Fund Activity: Q1 2025 in Review

352 of the 7,457 institutional investors tracked by Wall St. Rank reported a position in Axsome Therapeutics (AXSM) for Q1 2025, worth a combined $4.37B — up 39% from $3.15B a quarter earlier.

Buyers outnumbered sellers: 90 funds opened new AXSM positions and 28 closed out — a net gain of 62 holders — while 104 added to existing stakes and 115 trimmed.

The largest buyer was Assenagon Asset Management, adding an estimated $71.1M. The largest seller was RTW Investments, cutting an estimated $129M.

  • 352 institutional investors held Axsome Therapeutics (AXSM) as of Q1 2025, up from 292 in Q4 2024.
  • Funds reported $4.37B of Axsome Therapeutics stock for Q1 2025, up 39% quarter-over-quarter.
  • 90 funds opened new Axsome Therapeutics positions in Q1 2025 and 28 closed out, a net change of +62 holders.
  • The largest Axsome Therapeutics buyer in Q1 2025 was Assenagon Asset Management, an estimated $71.1M added.
  • The largest Axsome Therapeutics seller in Q1 2025 was RTW Investments, an estimated $129M sold.

Based on aggregated 13F filings for Q1 2025.