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Axsome Therapeutics
AXSM

352 hedge funds and large institutions have $4.37B invested in Axsome Therapeutics in 2025 Q1 according to their latest regulatory filings, with 90 funds opening new positions, 104 increasing their positions, 115 reducing their positions, and 28 closing their positions.

New
Increased
Maintained
Reduced
Closed

221% more first-time investments, than exits

New positions opened: 90 | Existing positions closed: 28

39% more capital invested

Capital invested by funds: $3.15B → $4.37B (+$1.22B)

28% more call options, than puts

Call options by funds: $111M | Put options by funds: $86.5M

21% more funds holding

Funds holding: 292 → 352 (+60)

9% more funds holding in top 10

Funds holding in top 10: 11 → 12 (+1)

0.05% more ownership

Funds ownership: 76.73% → 76.78% (+0.05%)

10% less repeat investments, than reductions

Existing positions increased: 104 | Existing positions reduced: 115

Holders
352
Holders Change
+60
Holders Change %
+20.55%
% of All Funds
4.72%
Holding in Top 10
12
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+9.09%
% of All Funds
0.16%
New
90
Increased
104
Reduced
115
Closed
28
Calls
$111M
Puts
$86.5M
Net Calls
+$24.5M
Net Calls Change
-$35M

Top Buyers

1
Assenagon Asset Management
Assenagon Asset Management
Luxembourg
+$71.1M
2
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$60.1M
3
O
OrbiMed
New York
+$44.1M
4
1832 Asset Management
1832 Asset Management
Ontario, Canada
+$41.4M
5
Man Group
Man Group
United Kingdom
+$39.9M

Top Sellers

1
RI
RTW Investments
New York
-$129M
2
RCM
RA Capital Management
Massachusetts
-$84.6M
3
FFM
Fairmount Funds Management
Pennsylvania
-$74.5M
4
Lazard Asset Management
Lazard Asset Management
New York
-$57.9M
5
HRCM
Hood River Capital Management
Florida
-$54.6M
Name Holding Trade Value Shares
Change 		Change in
Stake
GIA
226
Goodwin Investment Advisory
Georgia
$495K – – –
AWM
227
Aries Wealth Management
Maine
$467K – – –
FCM
228
Farallon Capital Management
California
$467K – – –
MCP
229
Mirador Capital Partners
California
$467K – – –
PA
230
Profund Advisors
Maryland
$453K -$114K -1,003 -21%
GCP
231
GSA Capital Partners
United Kingdom
$452K +$441K +3,873 New
JMFC
232
J.M. Forbes & Co
Massachusetts
$448K – – –
VIA
233
Virtus Investment Advisers
Connecticut
$444K +$434K +3,806 New
AIP
234
Ameritas Investment Partners
Nebraska
$437K -$11.7K -103 -3%
Public Employees Retirement Association of Colorado
235
Public Employees Retirement Association of Colorado
Colorado
$432K – – –
LSA
236
Leonteq Securities AG
Switzerland
$412K -$342 -3 -0.1%
ONSWM
237
Old North State Wealth Management
North Carolina
$402K – – –
XT
238
XTX Topco
Cayman Islands
$392K -$1.12M -9,794 -74%
Pathstone Holdings
239
Pathstone Holdings
New Jersey
$379K -$28.9K -254 -7%
Canada Life
240
Canada Life
Manitoba, Canada
$364K – – –
CAPTRUST Financial Advisors
241
CAPTRUST Financial Advisors
North Carolina
$362K +$17.2K +151 +5%
OSAM
242
O'Shaughnessy Asset Management
Connecticut
$362K +$354K +3,104 New
IB
243
Intrust Bank
Kansas
$361K +$30.8K +270 +10%
VA
244
Vident Advisory
Georgia
$360K +$351K +3,083 New
SP
245
SIH Partners
Delaware
$358K +$350K +3,071 New
X
246
Xponance
Pennsylvania
$337K +$26.4K +232 +9%
CC
247
Centiva Capital
New York
$329K +$321K +2,820 New
SG Americas Securities
248
SG Americas Securities
New York
$321K -$91.3K -801 -23%
PWM
249
Prosperity Wealth Management
California
$321K +$313K +2,750 New
Rafferty Asset Management
250
Rafferty Asset Management
New York
$318K -$103K -901 -25%
8 9
10
11 12

AXSM Hedge Fund Activity: Q1 2025 in Review

352 of the 7,457 institutional investors tracked by Wall St. Rank reported a position in Axsome Therapeutics (AXSM) for Q1 2025, worth a combined $4.37B — up 39% from $3.15B a quarter earlier.

Buyers outnumbered sellers: 90 funds opened new AXSM positions and 28 closed out — a net gain of 62 holders — while 104 added to existing stakes and 115 trimmed.

The largest buyer was Assenagon Asset Management, adding an estimated $71.1M. The largest seller was RTW Investments, cutting an estimated $129M.

  • 352 institutional investors held Axsome Therapeutics (AXSM) as of Q1 2025, up from 292 in Q4 2024.
  • Funds reported $4.37B of Axsome Therapeutics stock for Q1 2025, up 39% quarter-over-quarter.
  • 90 funds opened new Axsome Therapeutics positions in Q1 2025 and 28 closed out, a net change of +62 holders.
  • The largest Axsome Therapeutics buyer in Q1 2025 was Assenagon Asset Management, an estimated $71.1M added.
  • The largest Axsome Therapeutics seller in Q1 2025 was RTW Investments, an estimated $129M sold.

Based on aggregated 13F filings for Q1 2025.