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Ascendis Pharma A/S

279 hedge funds and large institutions have $12.7B invested in Ascendis Pharma A/S in 2025 Q3 according to their latest regulatory filings, with 56 funds opening new positions, 99 increasing their positions, 92 reducing their positions, and 22 closing their positions.

New
Increased
Maintained
Reduced
Closed

216% more call options, than puts

Call options by funds: $124M | Put options by funds: $39.3M

155% more first-time investments, than exits

New positions opened: 56 | Existing positions closed: 22

17% more capital invested

Capital invested by funds: $10.9B → $12.7B (+$1.83B)

13% more funds holding

Funds holding: 247279 (+32)

6% more funds holding in top 10

Funds holding in top 10: 1617 (+1)

8% more repeat investments, than reductions

Existing positions increased: 99 | Existing positions reduced: 92

0.65% more ownership

Funds ownership: 102.88%103.53% (+0.65%)

Holders
279
Holders Change
+32
Holders Change %
+12.96%
% of All Funds
3.66%
Holding in Top 10
17
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+6.25%
% of All Funds
0.22%
New
56
Increased
99
Reduced
92
Closed
22
Calls
$124M
Puts
$39.3M
Net Calls
+$84.9M
Net Calls Change
+$58.3M
Name Holding Trade Value Shares
Change
Change in
Stake
RCM
1
RA Capital Management
Massachusetts
$2.04B
Westfield Capital Management
2
Westfield Capital Management
Massachusetts
$1.05B -$35.7M -191,492 -4%
ACA
3
Avoro Capital Advisors
New York
$1.02B +$24.2M +130,000 +3%
Fidelity Investments
4
Fidelity Investments
Massachusetts
$889M -$11.2M -59,991 -1%
Janus Henderson Group
5
Janus Henderson Group
United Kingdom
$859M -$19.5M -104,733 -2%
Artisan Partners
6
Artisan Partners
Wisconsin
$740M -$50.3M -269,544 -7%
Capital International Investors
7
Capital International Investors
California
$608M +$2.55M +13,685 +0.4%
T. Rowe Price Investment Management
8
T. Rowe Price Investment Management
Maryland
$530M -$171M -916,928 -26%
Massachusetts Financial Services
9
Massachusetts Financial Services
Massachusetts
$374M -$3.56M -19,062 -1%
Wellington Management Group
10
Wellington Management Group
Massachusetts
$358M +$164M +880,836 +96%
T. Rowe Price Associates
11
T. Rowe Price Associates
Maryland
$343M -$27.8M -149,263 -8%
Franklin Resources
12
Franklin Resources
California
$316M -$30.5M -163,512 -9%
PA
13
Perceptive Advisors
New York
$216M +$23.2M +124,615 +13%
Invesco
14
Invesco
Georgia
$182M -$5.47M -29,323 -3%
PCH
15
Polar Capital Holdings
United Kingdom
$171M +$3.76M +20,134 +2%
Principal Financial Group
16
Principal Financial Group
Iowa
$158M +$143M +765,561 +2,723%
Goldman Sachs
17
Goldman Sachs
New York
$130M +$21.4M +114,725 +21%
VPC
18
Vestal Point Capital
New York
$119M +$74.6M +400,000 +200%
Ameriprise
19
Ameriprise
Minnesota
$112M -$4.69M -25,133 -4%
American Century Companies
20
American Century Companies
Missouri
$108M +$2.57M +13,797 +3%
Fidelity International
21
Fidelity International
Bermuda
$91.3M -$887K -4,756 -1%
BlackRock
22
BlackRock
New York
$89.8M -$3.77M -20,229 -4%
Morgan Stanley
23
Morgan Stanley
New York
$80.9M +$28.3M +151,976 +60%
SCM
24
Spyglass Capital Management
California
$77.3M +$72.5M +388,647 New
AllianceBernstein
25
AllianceBernstein
Tennessee
$74.7M -$336K -1,802 -0.5%

ASND Hedge Fund Activity: Q3 2025 in Review

279 of the 7,619 institutional investors tracked by Wall St. Rank reported a position in Ascendis Pharma A/S (ASND) for Q3 2025, worth a combined $12.7B — up 17% from $10.9B a quarter earlier.

Buyers outnumbered sellers: 56 funds opened new ASND positions and 22 closed out — a net gain of 34 holders — while 99 added to existing stakes and 92 trimmed.

The largest buyer was Wellington Management Group, adding an estimated $164M. The largest seller was T. Rowe Price Investment Management, cutting an estimated $171M.

  • 279 institutional investors held Ascendis Pharma A/S (ASND) as of Q3 2025, up from 247 in Q2 2025.
  • Funds reported $12.7B of Ascendis Pharma A/S stock for Q3 2025, up 17% quarter-over-quarter.
  • 56 funds opened new Ascendis Pharma A/S positions in Q3 2025 and 22 closed out, a net change of +34 holders.
  • The largest Ascendis Pharma A/S buyer in Q3 2025 was Wellington Management Group, an estimated $164M added.
  • The largest Ascendis Pharma A/S seller in Q3 2025 was T. Rowe Price Investment Management, an estimated $171M sold.

Based on aggregated 13F filings for Q3 2025.