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Ascendis Pharma A/S

ASND

Market cap $17.5B

302 hedge funds and large institutions have $13.8B invested in Ascendis Pharma A/S in 2025 Q4 according to their latest regulatory filings, with 62 funds opening new positions, 121 increasing their positions, 91 reducing their positions, and 37 closing their positions.

New

Increased

Maintained

Reduced

Closed

211% more call options, than puts

Call options by funds: $189M | Put options by funds: $60.8M

68% more first-time investments, than exits

New positions opened: 62 | Existing positions closed: 37

33% more repeat investments, than reductions

Existing positions increased: 121 | Existing positions reduced: 91

9% more capital invested

Capital invested by funds: $12.7B → $13.8B (+$1.09B)

8% more funds holding

Funds holding: 279 → 302 (+23)

0.91% more ownership

Funds ownership: 103.53% → 104.44% (+0.91%)

29% less funds holding in top 10

Funds holding in top 10: 17 → 12 (-5)

Holders

302

Holders Change

+23

Holders Change %

+8.24%

% of All Funds

3.67%

Holding in Top 10

Holding in Top 10 Change

-5

Holding in Top 10 Change %

-29.41%

% of All Funds

0.15%

New

Increased

121

Reduced

Closed

Calls

$189M

Puts

$60.8M

Net Calls

+$128M

Net Calls Change

+$43.4M

Top Buyers

1	American Century Companies Kansas City, Missouri	+$186M
2	Citadel Advisors Miami, Florida	+$102M
3	Susquehanna International Group Bala Cynwyd, Pennsylvania	+$97.3M
4	Franklin Resources San Mateo, California	+$66.1M
5	Principal Financial Group Des Moines, Iowa	+$48.1M

Top Sellers

1	T. Rowe Price Investment Management Baltimore, Maryland	-$206M
2	Artisan Partners Milwaukee, Wisconsin	-$102M
3	PCH Polar Capital Holdings London, United Kingdom	-$101M
4	VPC Vestal Point Capital New York	-$87.8M
5	Invesco Atlanta, Georgia	-$68.5M

#	Name	Holding	Trade Value	Shares Change	Change in Stake
26	SCM 26 Spyglass Capital Management San Francisco, California	$88.6M	+$5.56M	+26,902	+7%
27	PCH 27 Polar Capital Holdings London, United Kingdom	$79M	-$101M	-487,438	-57%
28	FAM 28 Fred Alger Management New York	$75.1M	+$37.5M	+181,408	+106%
29	29 UBS Group Zurich, Switzerland	$65.7M	+$23.3M	+112,986	+58%
30	30 BNP Paribas Financial Markets Paris, France	$65.5M	+$14.2M	+68,555	+29%
31	31 Deutsche Bank Frankfurt Am Main Ge, Germany	$63.3M	+$46.9M	+227,259	+327%
32	32 AllianceBernstein Nashville, Tennessee	$61.5M	-$18M	-87,307	-23%
33	33 SEI Investments Oaks, Pennsylvania	$60M	+$15.7M	+76,154	+37%
34	TLP 34 Tri Locum Partners New York	$56.5M	+$18.6M	+90,186	+52%
35	35 Millennium Management New York	$55.9M	+$18.1M	+87,726	+50%
36	36 Two Sigma Investments New York	$52.9M	+$13.2M	+64,006	+35%
37	SL 37 Siren LLC Greenwich, Connecticut	$50.3M	–	–	–
38	38 TD Asset Management Toronto, Ontario, Canada	$49.9M	-$12.9M	-62,334	-21%
39	39 Aberdeen Group Edinburgh, United Kingdom	$47.3M	+$35.6M	+172,251	+349%
40	JG 40 Jain Global New York	$46.2M	+$37.3M	+180,564	+502%
41	41 Voloridge Investment Management Jupiter, Florida	$46.1M	-$3.76M	-18,224	-8%
42	RSCM 42 Rock Springs Capital Management Baltimore, Maryland	$43.4M	-$2.27M	-11,000	-5%
43	43 Bank of New York Mellon New York	$41.5M	-$3.03M	-14,693	-7%
44	44 Qube Research & Technologies (QRT) London, United Kingdom	$41.3M	-$20M	-96,708	-33%
45	QGA 45 Q Global Advisors Fort Worth, Texas	$40.5M	+$4.13M	+20,000	+12%
46	46 Allspring Global Investments Charlotte, North Carolina	$40M	-$832K	-4,030	-2%
47	CS 47 Candriam SCA Strassen, Luxembourg, Luxembourg	$39.9M	+$1.65M	+7,984	+4%
48	48 New York State Common Retirement Fund Albany, New York	$38.9M	+$2.55M	+12,340	+7%
49	PHS 49 PFM Health Sciences San Francisco, California	$37.9M	+$6.69M	+32,374	+22%
50	VPC 50 Vestal Point Capital New York	$37.3M	-$87.8M	-425,000	-71%