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Ascendis Pharma A/S

247 hedge funds and large institutions have $10.9B invested in Ascendis Pharma A/S in 2025 Q2 according to their latest regulatory filings, with 44 funds opening new positions, 82 increasing their positions, 88 reducing their positions, and 40 closing their positions.

New
Increased
Maintained
Reduced
Closed

210% more call options, than puts

Call options by funds: $39.2M | Put options by funds: $12.6M

14% more funds holding in top 10

Funds holding in top 10: 1416 (+2)

10% more first-time investments, than exits

New positions opened: 44 | Existing positions closed: 40

7% more capital invested

Capital invested by funds: $10.1B → $10.9B (+$708M)

1% more funds holding

Funds holding: 244247 (+3)

7% less repeat investments, than reductions

Existing positions increased: 82 | Existing positions reduced: 88

4.51% less ownership

Funds ownership: 107.4%102.88% (-4.5%)

Holders
247
Holders Change
+3
Holders Change %
+1.23%
% of All Funds
3.25%
Holding in Top 10
16
Holding in Top 10 Change
+2
Holding in Top 10 Change %
+14.29%
% of All Funds
0.21%
New
44
Increased
82
Reduced
88
Closed
40
Calls
$39.2M
Puts
$12.6M
Net Calls
+$26.6M
Net Calls Change
+$41.1M
Name Holding Trade Value Shares
Change
Change in
Stake
DFO
251
Duquesne Family Office
New York
-$24.7M -158,720 Closed
B
252
Braidwell
Connecticut
-$16.6M -106,713 Closed
IHAM
253
Integral Health Asset Management
New York
-$15.6M -100,000 Closed
EHI
254
Eagle Health Investments
Connecticut
-$8.81M -56,500 Closed
GPP
255
Great Point Partners
Connecticut
-$7.79M -50,000 Closed
Jane Street
256
Jane Street
New York
-$7.87M -48,299 Closed
Alyeska Investment Group
257
Alyeska Investment Group
Illinois
-$6.61M -42,416 Closed
Tudor Investment Corp
258
Tudor Investment Corp
Connecticut
-$3.32M -21,299 Closed
HighTower Advisors
259
HighTower Advisors
Illinois
-$2.81M -18,032 Closed
SC
260
Stempoint Capital
New York
-$2.3M -14,732 Closed
CCIA
261
Campbell & Co Investment Adviser
Maryland
-$2.03M -13,036 Closed
PE
262
Point72 Europe
United Kingdom
-$1.88M -12,053 Closed
Susquehanna International Group
263
Susquehanna International Group
Pennsylvania
-$1.86M -11,395 Closed
AC
264
Aristeia Capital
Connecticut
-$1.76M -11,300 Closed
DP
265
Diadema Partners
New Jersey
-$1.3M -8,321 Closed
QC
266
Quantessence Capital
New York
-$1.06M -6,788 Closed
WC
267
Wexford Capital
Florida
-$779K -5,000 Closed
HSBC Holdings
268
HSBC Holdings
United Kingdom
-$661K -4,378 Closed
SP
269
SIH Partners
Delaware
-$593K -3,807 Closed
PCM
270
Penserra Capital Management
California
-$420K -2,695 Closed
DZ Bank
271
DZ Bank
Germany
-$393K -2,524 Closed
SFAM
272
Springhill Fund Asset Management
Hong Kong
-$339K -2,173 Closed
C
273
Certuity
Florida
-$297K -1,907 Closed
PAP
274
Persistent Asset Partners
Hong Kong
-$297K -1,906 Closed
NAAA
275
New Age Alpha Advisors
New York
-$268K -1,721 Closed

ASND Hedge Fund Activity: Q2 2025 in Review

247 of the 7,595 institutional investors tracked by Wall St. Rank reported a position in Ascendis Pharma A/S (ASND) for Q2 2025, worth a combined $10.9B — up 7% from $10.1B a quarter earlier.

Buyers outnumbered sellers: 44 funds opened new ASND positions and 40 closed out — a net gain of 4 holders — while 82 added to existing stakes and 88 trimmed.

The largest buyer was Perceptive Advisors, opening a new position worth an estimated $157M. The largest seller was Morgan Stanley, cutting an estimated $269M.

  • 247 institutional investors held Ascendis Pharma A/S (ASND) as of Q2 2025, up from 244 in Q1 2025.
  • Funds reported $10.9B of Ascendis Pharma A/S stock for Q2 2025, up 7% quarter-over-quarter.
  • 44 funds opened new Ascendis Pharma A/S positions in Q2 2025 and 40 closed out, a net change of +4 holders.
  • The largest Ascendis Pharma A/S buyer in Q2 2025 was Perceptive Advisors, an estimated $157M added.
  • The largest Ascendis Pharma A/S seller in Q2 2025 was Morgan Stanley, an estimated $269M sold.

Based on aggregated 13F filings for Q2 2025.