Applied Therapeutics
APLT
APLT was delisted on the 2nd of February, 2026.
71 hedge funds and large institutions have $26M invested in Applied Therapeutics in 2022 Q1 according to their latest regulatory filings, with 15 funds opening new positions, 19 increasing their positions, 19 reducing their positions, and 13 closing their positions.
15% more first-time investments, than exits
New positions opened: 15 | Existing positions closed: 13
3% more funds holding
Funds holding: 69 → 71 (+2)
0% more funds holding in top 10
Funds holding in top 10: 1 → 1 (0)
0% more repeat investments, than reductions
Existing positions increased: 19 | Existing positions reduced: 19
9.81% less ownership
Funds ownership: 56.91% → 47.1% (-9.8%)
61% less call options, than puts
Call options by funds: $22K | Put options by funds: $57K
80% less capital invested
Capital invested by funds: $133M → $26M (-$107M)
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Point72 Asset Management
Stamford,
Connecticut
|
+$3.84M |
| 2 |
Franklin Resources
San Mateo,
California
|
+$1.26M |
| 3 |
Renaissance Technologies
New York
|
+$709K |
| 4 |
Two Sigma Investments
New York
|
+$675K |
| 5 |
D.E. Shaw & Co
New York
|
+$392K |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
O
OrbiMed
New York
|
-$20.7M |
| 2 |
EMFAT
Emerald Mutual Fund Advisers Trust
Leola,
Pennsylvania
|
-$5.66M |
| 3 |
EA
Emerald Advisers
Leola,
Pennsylvania
|
-$5.47M |
| 4 |
DCM
Driehaus Capital Management
Chicago,
Illinois
|
-$4.63M |
| 5 |
Fidelity Investments
Boston,
Massachusetts
|
-$3.59M |
| Name | Holding | Trade Value |
Shares Change |
Change in Stake |
|
|---|---|---|---|---|---|
76
Ensign Peak Advisors
Salt Lake City,
Utah
| – | -$107K | -11,940 | Closed |
|
77
Manulife (Manufacturers Life Insurance)
Canada,
Ontario, Canada
| – | -$100 | -11,189 | Closed |
|
|
TI
78
Trexquant Investment
Stamford,
Connecticut
| – | -$99K | -11,091 | Closed |
|
|
DA
79
Denali Advisors
San Diego,
California
| – | -$25K | -2,800 | Closed |
|
|
ACM
80
Aquatic Capital Management
Chicago,
Illinois
| – | -$7K | -800 | Closed |
|
|
QCG
81
Quadrant Capital Group
Cincinnati,
Ohio
| – | -$1K | -113 | Closed |
|
|
CG
82
Cutler Group
San Francisco,
California
| – | +$589 | +220 | New |
|
APLT Hedge Fund Activity: Q1 2022 in Review
71 of the 6,341 institutional investors tracked by Wall St. Rank reported a position in Applied Therapeutics (APLT) for Q1 2022, worth a combined $26M — down 80% from $133M a quarter earlier.
Buyers outnumbered sellers: 15 funds opened new APLT positions and 13 closed out — a net gain of 2 holders — while 19 added to existing stakes and 19 trimmed.
The largest buyer was Point72 Asset Management, adding an estimated $3.84M. The largest seller was OrbiMed, exiting entirely with an estimated $20.7M sold.
- 71 institutional investors held Applied Therapeutics (APLT) as of Q1 2022, up from 69 in Q4 2021.
- Funds reported $26M of Applied Therapeutics stock for Q1 2022, down 80% quarter-over-quarter.
- 15 funds opened new Applied Therapeutics positions in Q1 2022 and 13 closed out, a net change of +2 holders.
- The largest Applied Therapeutics buyer in Q1 2022 was Point72 Asset Management, an estimated $3.84M added.
- The largest Applied Therapeutics seller in Q1 2022 was OrbiMed, an estimated $20.7M sold.
Based on aggregated 13F filings for Q1 2022.