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Annexon
ANNX

129 hedge funds and large institutions have $239M invested in Annexon in 2025 Q2 according to their latest regulatory filings, with 20 funds opening new positions, 50 increasing their positions, 34 reducing their positions, and 37 closing their positions.

New
Increased
Maintained
Reduced
Closed

47% more repeat investments, than reductions

Existing positions increased: 50 | Existing positions reduced: 34

24% more capital invested

Capital invested by funds: $192M → $239M (+$46.6M)

0.03% less ownership

Funds ownership: 90.91% → 90.88% (-0.03%)

12% less funds holding

Funds holding: 146 → 129 (-17)

46% less first-time investments, than exits

New positions opened: 20 | Existing positions closed: 37

67% less call options, than puts

Call options by funds: $50K | Put options by funds: $153K

Holders
129
Holders Change
-17
Holders Change %
-11.64%
% of All Funds
1.7%
Holding in Top 10
1
Holding in Top 10 Change
+1
Holding in Top 10 Change %
% of All Funds
0.01%
New
20
Increased
50
Reduced
34
Closed
37
Calls
$50K
Puts
$153K
Net Calls
-$103K
Net Calls Change
-$67K

Top Buyers

Rank Fund Capital Flow
1
Fidelity Investments
Fidelity Investments
Massachusetts
+$4.88M
2
Millennium Management
Millennium Management
New York
+$4.69M
3
Goldman Sachs
Goldman Sachs
New York
+$1.58M
4
SCM
Sio Capital Management
New York
+$1.4M
5
Bank of America
Bank of America
North Carolina
+$830K

Top Sellers

Rank Fund Capital Flow
1
Ameriprise
Ameriprise
Minnesota
-$3.65M
2
LGM
Logos Global Management
California
-$3.19M
3
JP Morgan Chase
JP Morgan Chase
New York
-$2.76M
4
WP
Woodline Partners
California
-$2.13M
5
BlackRock
BlackRock
New York
-$1.13M
Name Holding Trade Value Shares
Change 		Change in
Stake
VRS
151
Virginia Retirement Systems
Virginia
– -$39.8K -20,600 Closed
ASRS
152
Arizona State Retirement System
Arizona
– -$38.4K -19,875 Closed
Teacher Retirement System of Texas
153
Teacher Retirement System of Texas
Texas
– -$37.6K -19,462 Closed
KK
154
KLP Kapitalforvaltning
Norway
– -$36.9K -19,100 Closed
QCM
155
Quantinno Capital Management
New York
– -$34.3K -17,770 Closed
Canada Life
156
Canada Life
Manitoba, Canada
– -$29K -14,935 Closed
AC
157
AXQ Capital
New Jersey
– -$27.2K -14,117 Closed
LPL Financial
158
LPL Financial
California
– -$24.9K -12,926 Closed
CFM
159
Catalyst Funds Management
Australia
– -$22.7K -11,760 Closed
GCP
160
GSA Capital Partners
United Kingdom
– -$22K -11,425 Closed
DTL
161
Dynamic Technology Lab
Singapore
– -$21K -10,947 Closed
CIBC Private Wealth Group
162
CIBC Private Wealth Group
Georgia
– -$1.03K -670 Closed
PWMG
163
Private Wealth Management Group
New Jersey
– -$1.26K -654 Closed
Group One Trading
164
Group One Trading
Illinois
– -$878 -438 Closed
PFBT
165
Parkside Financial Bank & Trust
Missouri
– -$273 -140 Closed
TWD
166
True Wealth Design
Ohio
– -$33 -17 Closed
3 4 5 6
7

ANNX Hedge Fund Activity: Q2 2025 in Review

129 of the 7,595 institutional investors tracked by Wall St. Rank reported a position in Annexon (ANNX) for Q2 2025, worth a combined $239M — up 24% from $192M a quarter earlier.

Sellers outnumbered buyers: 37 funds closed out of ANNX and 20 opened new positions — a net loss of 17 holders — while 34 trimmed existing stakes and 50 added.

The largest buyer was Fidelity Investments, adding an estimated $4.88M. The largest seller was Ameriprise, cutting an estimated $3.65M.

  • 129 institutional investors held Annexon (ANNX) as of Q2 2025, down from 146 in Q1 2025.
  • Funds reported $239M of Annexon stock for Q2 2025, up 24% quarter-over-quarter.
  • 20 funds opened new Annexon positions in Q2 2025 and 37 closed out, a net change of -17 holders.
  • The largest Annexon buyer in Q2 2025 was Fidelity Investments, an estimated $4.88M added.
  • The largest Annexon seller in Q2 2025 was Ameriprise, an estimated $3.65M sold.

Based on aggregated 13F filings for Q2 2025.