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Annexon
ANNX

129 hedge funds and large institutions have $239M invested in Annexon in 2025 Q2 according to their latest regulatory filings, with 20 funds opening new positions, 50 increasing their positions, 34 reducing their positions, and 37 closing their positions.

New
Increased
Maintained
Reduced
Closed

47% more repeat investments, than reductions

Existing positions increased: 50 | Existing positions reduced: 34

24% more capital invested

Capital invested by funds: $192M → $239M (+$46.6M)

0.03% less ownership

Funds ownership: 90.91% → 90.88% (-0.03%)

12% less funds holding

Funds holding: 146 → 129 (-17)

46% less first-time investments, than exits

New positions opened: 20 | Existing positions closed: 37

67% less call options, than puts

Call options by funds: $50K | Put options by funds: $153K

Holders
129
Holders Change
-17
Holders Change %
-11.64%
% of All Funds
1.7%
Holding in Top 10
1
Holding in Top 10 Change
+1
Holding in Top 10 Change %
% of All Funds
0.01%
New
20
Increased
50
Reduced
34
Closed
37
Calls
$50K
Puts
$153K
Net Calls
-$103K
Net Calls Change
-$67K

Top Buyers

Rank Fund Capital Flow
1
Fidelity Investments
Fidelity Investments
Massachusetts
+$4.88M
2
Millennium Management
Millennium Management
New York
+$4.69M
3
Goldman Sachs
Goldman Sachs
New York
+$1.58M
4
SCM
Sio Capital Management
New York
+$1.4M
5
Bank of America
Bank of America
North Carolina
+$830K

Top Sellers

Rank Fund Capital Flow
1
Ameriprise
Ameriprise
Minnesota
-$3.65M
2
LGM
Logos Global Management
California
-$3.19M
3
JP Morgan Chase
JP Morgan Chase
New York
-$2.76M
4
WP
Woodline Partners
California
-$2.13M
5
BlackRock
BlackRock
New York
-$1.13M
Name Holding Trade Value Shares
Change 		Change in
Stake
IA
126
IFP Advisors
Florida
$259 +$217 +108 New
AF
127
Allworth Financial
California
$108 +$90 +45 New
SS
128
SBI Securities
Japan
$72 +$10 +5 +20%
FFA
129
Farther Finance Advisors
California
$2 – – –
Wellington Management Group
130
Wellington Management Group
Massachusetts
– -$688K -356,480 Closed
SC
131
Syon Capital
California
– -$279K -144,485 Closed
Swiss National Bank
132
Swiss National Bank
Switzerland
– -$261K -135,000 Closed
Squarepoint
133
Squarepoint
New York
– -$257K -132,997 Closed
Balyasny Asset Management
134
Balyasny Asset Management
Illinois
– -$187K -96,752 Closed
State of Wisconsin Investment Board
135
State of Wisconsin Investment Board
Wisconsin
– -$158K -81,636 Closed
HF
136
HRT Financial
New York
– -$150K -78,100 Closed
California State Teachers Retirement System (CalSTRS)
137
California State Teachers Retirement System (CalSTRS)
California
– -$128K -66,375 Closed
YIH
138
Y-Intercept (HK)
Hong Kong
– -$127K -65,918 Closed
SG Americas Securities
139
SG Americas Securities
New York
– -$122K -63,161 Closed
JG
140
Jain Global
New York
– -$118K -61,276 Closed
XT
141
XTX Topco
Cayman Islands
– -$112K -58,130 Closed
EC
142
EntryPoint Capital
New York
– -$103K -53,271 Closed
Franklin Resources
143
Franklin Resources
California
– -$94.8K -49,123 Closed
CF
144
Corebridge Financial
Texas
– -$92.3K -47,838 Closed
Point72 Asset Management
145
Point72 Asset Management
Connecticut
– -$88.2K -45,714 Closed
SFI
146
Susquehanna Fundamental Investments
Pennsylvania
– -$79.2K -41,011 Closed
SC
147
Shay Capital
New York
– -$67.9K -35,162 Closed
Janus Henderson Group
148
Janus Henderson Group
United Kingdom
– -$77.8K -34,500 Closed
Zurich Cantonal Bank
149
Zurich Cantonal Bank
Switzerland
– -$65.7K -34,026 Closed
AGM
150
Alpine Global Management
New York
– -$48.5K -25,145 Closed
3 4 5
6
7

ANNX Hedge Fund Activity: Q2 2025 in Review

129 of the 7,595 institutional investors tracked by Wall St. Rank reported a position in Annexon (ANNX) for Q2 2025, worth a combined $239M — up 24% from $192M a quarter earlier.

Sellers outnumbered buyers: 37 funds closed out of ANNX and 20 opened new positions — a net loss of 17 holders — while 34 trimmed existing stakes and 50 added.

The largest buyer was Fidelity Investments, adding an estimated $4.88M. The largest seller was Ameriprise, cutting an estimated $3.65M.

  • 129 institutional investors held Annexon (ANNX) as of Q2 2025, down from 146 in Q1 2025.
  • Funds reported $239M of Annexon stock for Q2 2025, up 24% quarter-over-quarter.
  • 20 funds opened new Annexon positions in Q2 2025 and 37 closed out, a net change of -17 holders.
  • The largest Annexon buyer in Q2 2025 was Fidelity Investments, an estimated $4.88M added.
  • The largest Annexon seller in Q2 2025 was Ameriprise, an estimated $3.65M sold.

Based on aggregated 13F filings for Q2 2025.