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Annexon
ANNX

217 hedge funds and large institutions have $864M invested in Annexon in 2026 Q1 according to their latest regulatory filings, with 66 funds opening new positions, 86 increasing their positions, 50 reducing their positions, and 15 closing their positions.

New
Increased
Maintained
Reduced
Closed

665% more call options, than puts

Call options by funds: $6.69M | Put options by funds: $875K

340% more first-time investments, than exits

New positions opened: 66 | Existing positions closed: 15

72% more repeat investments, than reductions

Existing positions increased: 86 | Existing positions reduced: 50

29% more funds holding

Funds holding: 168 → 217 (+49)

26% more capital invested

Capital invested by funds: $687M → $864M (+$176M)

25% more funds holding in top 10

Funds holding in top 10: 4 → 5 (+1)

15.9% more ownership

Funds ownership: 114.45% → 130.36% (+16%)

Holders
217
Holders Change
+49
Holders Change %
+29.17%
% of All Funds
2.67%
Holding in Top 10
5
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+25%
% of All Funds
0.06%
New
66
Increased
86
Reduced
50
Closed
15
Calls
$6.69M
Puts
$875K
Net Calls
+$5.82M
Net Calls Change
+$4.22M

Top Buyers

Rank Fund Capital Flow
1
RG
Redmile Group
California
+$25.3M
2
SL
Siren LLC
Connecticut
+$22.3M
3
Bank of America
Bank of America
North Carolina
+$14.9M
4
GPP
Great Point Partners
Connecticut
+$14.1M
5
State Street
State Street
Massachusetts
+$12.8M

Top Sellers

Rank Fund Capital Flow
1
LP
Longaeva Partners
Illinois
-$14M
2
WP
Woodline Partners
California
-$9.36M
3
Millennium Management
Millennium Management
New York
-$9M
4
Adage Capital Partners
Adage Capital Partners
Massachusetts
-$6.76M
5
SFM
Sphera Funds Management
Israel
-$6.61M
Name Holding Trade Value Shares
Change 		Change in
Stake
Renaissance Technologies
51
Renaissance Technologies
New York
$3.02M -$1.45M -258,300 -32%
Wellington Management Group
52
Wellington Management Group
Massachusetts
$2.89M +$694K +123,302 +31%
HWAM
53
Hennion & Walsh Asset Management
New Jersey
$2.82M -$142K -25,297 -5%
SCM
54
Silverarc Capital Management
Massachusetts
$2.75M +$2.79M +496,461 New
BOTOTLSJU
55
Board of Trustees of The Leland Stanford Junior University
California
$2.67M – – –
Two Sigma Investments
56
Two Sigma Investments
New York
$2.61M +$784K +139,353 +42%
Voloridge Investment Management
57
Voloridge Investment Management
Florida
$2.56M +$2.6M +462,068 New
T. Rowe Price Associates
58
T. Rowe Price Associates
Maryland
$2.38M -$92.1K -16,354 -4%
MOACM
59
Mutual of America Capital Management
New York
$2.31M -$1.27M -225,340 -35%
TI
60
Trexquant Investment
Connecticut
$2.24M +$2.27M +403,657 New
Bank of New York Mellon
61
Bank of New York Mellon
New York
$2.19M +$188K +33,342 +9%
SPS
62
Susquehanna Portfolio Strategies
Pennsylvania
$2M +$20.8K +3,700 +1%
JP Morgan Chase
63
JP Morgan Chase
New York
$1.61M +$1.52M +270,165 +503%
CCM
64
Cinctive Capital Management
New York
$1.49M -$509K -90,346 -25%
BNP Paribas Financial Markets
65
BNP Paribas Financial Markets
France
$1.41M +$1.09M +193,799 +315%
Swiss National Bank
66
Swiss National Bank
Switzerland
$1.31M +$1.33M +236,000 New
Rafferty Asset Management
67
Rafferty Asset Management
New York
$1.13M +$347K +61,625 +44%
SEI Investments
68
SEI Investments
Pennsylvania
$1.13M +$816K +144,977 +249%
RA
69
Rosalind Advisors
Ontario, Canada
$1.11M +$1.13M +200,000 New
IC
70
IEQ Capital
California
$1.08M +$72K +12,782 +7%
II
71
Ishara Investments
California
$965K -$3.24M -575,750 -77%
EGM
72
Engineers Gate Manager
New York
$965K +$980K +174,141 New
JGC
73
J. Goldman & Co
New York
$946K -$4.63M -822,978 -83%
BFM
74
Boothbay Fund Management
New York
$921K +$575K +102,095 +159%
RhumbLine Advisers
75
RhumbLine Advisers
Massachusetts
$885K +$187K +33,207 +26%
1 2
3
4 5

ANNX Hedge Fund Activity: Q1 2026 in Review

217 of the 8,126 institutional investors tracked by Wall St. Rank reported a position in Annexon (ANNX) for Q1 2026, worth a combined $864M — up 26% from $687M a quarter earlier.

Buyers outnumbered sellers: 66 funds opened new ANNX positions and 15 closed out — a net gain of 51 holders — while 86 added to existing stakes and 50 trimmed.

The largest buyer was Redmile Group, adding an estimated $25.3M. The largest seller was Longaeva Partners, cutting an estimated $14M.

  • 217 institutional investors held Annexon (ANNX) as of Q1 2026, up from 168 in Q4 2025.
  • Funds reported $864M of Annexon stock for Q1 2026, up 26% quarter-over-quarter.
  • 66 funds opened new Annexon positions in Q1 2026 and 15 closed out, a net change of +51 holders.
  • The largest Annexon buyer in Q1 2026 was Redmile Group, an estimated $25.3M added.
  • The largest Annexon seller in Q1 2026 was Longaeva Partners, an estimated $14M sold.

Based on aggregated 13F filings for Q1 2026.