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Annexon
ANNX

217 hedge funds and large institutions have $864M invested in Annexon in 2026 Q1 according to their latest regulatory filings, with 66 funds opening new positions, 86 increasing their positions, 50 reducing their positions, and 15 closing their positions.

New
Increased
Maintained
Reduced
Closed

665% more call options, than puts

Call options by funds: $6.69M | Put options by funds: $875K

340% more first-time investments, than exits

New positions opened: 66 | Existing positions closed: 15

72% more repeat investments, than reductions

Existing positions increased: 86 | Existing positions reduced: 50

29% more funds holding

Funds holding: 168 → 217 (+49)

26% more capital invested

Capital invested by funds: $687M → $864M (+$176M)

25% more funds holding in top 10

Funds holding in top 10: 4 → 5 (+1)

15.9% more ownership

Funds ownership: 114.45% → 130.36% (+16%)

Holders
217
Holders Change
+49
Holders Change %
+29.17%
% of All Funds
2.67%
Holding in Top 10
5
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+25%
% of All Funds
0.06%
New
66
Increased
86
Reduced
50
Closed
15
Calls
$6.69M
Puts
$875K
Net Calls
+$5.82M
Net Calls Change
+$4.22M

Top Buyers

Rank Fund Capital Flow
1
RG
Redmile Group
California
+$25.3M
2
SL
Siren LLC
Connecticut
+$22.3M
3
Bank of America
Bank of America
North Carolina
+$14.9M
4
GPP
Great Point Partners
Connecticut
+$14.1M
5
State Street
State Street
Massachusetts
+$12.8M

Top Sellers

Rank Fund Capital Flow
1
LP
Longaeva Partners
Illinois
-$14M
2
WP
Woodline Partners
California
-$9.36M
3
Millennium Management
Millennium Management
New York
-$9M
4
Adage Capital Partners
Adage Capital Partners
Massachusetts
-$6.76M
5
SFM
Sphera Funds Management
Israel
-$6.61M
Name Holding Trade Value Shares
Change 		Change in
Stake
YIH
26
Y-Intercept (HK)
Hong Kong
$7.31M +$7.43M +1,319,913 New
TAM
27
TFG Asset Management
Cayman Islands
$7.16M -$4.17M -740,000 -36%
UBS Group
28
UBS Group
Switzerland
$6.9M +$4.89M +868,837 +230%
Millennium Management
29
Millennium Management
New York
$6.86M -$9M -1,598,179 -56%
Charles Schwab
30
Charles Schwab
California
$6.11M +$255K +45,385 +4%
Northern Trust
31
Northern Trust
Illinois
$6.02M +$1.66M +294,902 +37%
Dimensional Fund Advisors
32
Dimensional Fund Advisors
Texas
$5.12M +$1.16M +205,398 +29%
KCM
33
Kennedy Capital Management
Missouri
$5.05M +$1.53M +272,421 +43%
Massachusetts Financial Services
34
Massachusetts Financial Services
Massachusetts
$5M -$400 -71 -0%
VFT
35
Vanguard Fiduciary Trust
Pennsylvania
$4.92M +$5M +888,552 New
Marshall Wace
36
Marshall Wace
United Kingdom
$4.77M +$1.92M +340,477 +65%
AQR Capital Management
37
AQR Capital Management
Connecticut
$4.31M +$5.33K +946 +0.1%
Invesco
38
Invesco
Georgia
$4.23M -$1.18M -209,444 -22%
Acadian Asset Management
39
Acadian Asset Management
Massachusetts
$4.2M -$580K -103,013 -12%
Russell Investments Group
40
Russell Investments Group
United Kingdom
$3.94M +$160K +28,364 +4%
D.E. Shaw & Co
41
D.E. Shaw & Co
New York
$3.89M -$1.93M -343,422 -33%
Wells Fargo
42
Wells Fargo
California
$3.87M +$704K +124,991 +22%
PHP
43
Parkman Healthcare Partners
Connecticut
$3.73M +$410K +72,811 +12%
Ensign Peak Advisors
44
Ensign Peak Advisors
Utah
$3.46M +$3.52M +625,097 New
LP
45
Longaeva Partners
Illinois
$3.44M -$14M -2,479,599 -80%
Citadel Advisors
46
Citadel Advisors
Florida
$3.32M +$1.83M +324,841 +118%
DM
47
Deerfield Management
New York
$3.23M – – –
IC
48
Ikarian Capital
Texas
$3.21M +$1.97M +350,000 +152%
SCM
49
Sirios Capital Management
Massachusetts
$3.19M -$761K -135,193 -19%
Deutsche Bank
50
Deutsche Bank
Germany
$3.11M +$8.09K +1,437 +0.3%
1
2
3 4 5

ANNX Hedge Fund Activity: Q1 2026 in Review

217 of the 8,126 institutional investors tracked by Wall St. Rank reported a position in Annexon (ANNX) for Q1 2026, worth a combined $864M — up 26% from $687M a quarter earlier.

Buyers outnumbered sellers: 66 funds opened new ANNX positions and 15 closed out — a net gain of 51 holders — while 86 added to existing stakes and 50 trimmed.

The largest buyer was Redmile Group, adding an estimated $25.3M. The largest seller was Longaeva Partners, cutting an estimated $14M.

  • 217 institutional investors held Annexon (ANNX) as of Q1 2026, up from 168 in Q4 2025.
  • Funds reported $864M of Annexon stock for Q1 2026, up 26% quarter-over-quarter.
  • 66 funds opened new Annexon positions in Q1 2026 and 15 closed out, a net change of +51 holders.
  • The largest Annexon buyer in Q1 2026 was Redmile Group, an estimated $25.3M added.
  • The largest Annexon seller in Q1 2026 was Longaeva Partners, an estimated $14M sold.

Based on aggregated 13F filings for Q1 2026.