D.E. Shaw & Co
ANNX icon

D.E. Shaw & Co’s Annexon ANNX Stock Holding History

D.E. Shaw & Co’s Portfolio ANNX Stock Details ANNX Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$3.89M Sell
702,799
-343,422
-33% -$1.93M ﹤0.01% 2374
2025
Q4 		$5.25M Buy
+1,046,221
New +$4M ﹤0.01% 2254
2024
Q4 		– Sell
-81,411
Closed -$482K – 4383
2024
Q3 		$482K Sell
81,411
-10,674
-12% -$63.3K ﹤0.01% 3726
2024
Q2 		$451K Sell
92,085
-287,169
-76% -$1.49M ﹤0.01% 3691
2024
Q1 		$2.72M Buy
+379,254
New +$1.97M ﹤0.01% 2389
2023
Q2 		– Sell
-27,136
Closed -$104K – 4215
2023
Q1 		$104K Sell
27,136
-51,373
-65% -$283K ﹤0.01% 3976
2022
Q4 		$406K Buy
78,509
+30,484
+63% +$167K ﹤0.01% 3965
2022
Q3 		$297K Buy
48,025
+9,699
+25% +$52.4K ﹤0.01% 4304
2022
Q2 		$144K Sell
38,326
-125,053
-77% -$382K ﹤0.01% 4654
2022
Q1 		$446K Buy
+163,379
New +$1.01M ﹤0.01% 4440

Other funds holding ANNX

RG
Redmile Group San Francisco, California $1.51B AUM 164.17% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
Fidelity Investments
Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return
BI
BVF Inc San Francisco, California $3.14B AUM 249.53% 1-Year Est. Return
State Street
State Street Boston, Massachusetts $2.9T AUM 29.55% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
BCLSI
Bain Capital Life Sciences Investors Boston, Massachusetts $1.11B AUM 171.34% 1-Year Est. Return
BG
Bellevue Group Kuesnacht, Switzerland $4.2B AUM 54.85% 1-Year Est. Return
MCO
MAK Capital One New York $679M AUM 29.02% 1-Year Est. Return
Adage Capital Partners
Adage Capital Partners Boston, Massachusetts $64.8B AUM 42.7% 1-Year Est. Return

D.E. Shaw & Co's ANNX Position: Q1 2026 in Review

D.E. Shaw & Co reduced its Annexon (ANNX) stake by 33% in Q1 2026, selling an estimated $1.93M and leaving 702,799 shares worth $3.89M. The position accounts for ﹤0.01% of the portfolio, ranked #2374.

D.E. Shaw & Co first reported a position in ANNX in Q1 2022 and has held it in 10 quarters since. The position peaked at $5.25M in Q4 2025. 217 funds tracked by Wall St. Rank hold ANNX as of Q1 2026.

  • D.E. Shaw & Co held 702,799 shares of Annexon worth $3.89M as of Q1 2026.
  • D.E. Shaw & Co sold 343,422 Annexon shares in Q1 2026, an estimated $1.93M.
  • Annexon made up ﹤0.01% of D.E. Shaw & Co's portfolio in Q1 2026, its #2374 holding.
  • D.E. Shaw & Co first reported a position in Annexon in Q1 2022 and has held it in 10 quarters since.
  • D.E. Shaw & Co's Annexon position peaked at $5.25M in Q4 2025.
  • 217 funds tracked by Wall St. Rank held Annexon as of Q1 2026.

Based on D.E. Shaw & Co's 13F filing for Q1 2026, filed 15 May 2026.