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Annexon
ANNX

129 hedge funds and large institutions have $239M invested in Annexon in 2025 Q2 according to their latest regulatory filings, with 20 funds opening new positions, 50 increasing their positions, 34 reducing their positions, and 37 closing their positions.

New
Increased
Maintained
Reduced
Closed

47% more repeat investments, than reductions

Existing positions increased: 50 | Existing positions reduced: 34

24% more capital invested

Capital invested by funds: $192M → $239M (+$46.6M)

0.03% less ownership

Funds ownership: 90.91% → 90.88% (-0.03%)

12% less funds holding

Funds holding: 146 → 129 (-17)

46% less first-time investments, than exits

New positions opened: 20 | Existing positions closed: 37

67% less call options, than puts

Call options by funds: $50K | Put options by funds: $153K

Holders
129
Holders Change
-17
Holders Change %
-11.64%
% of All Funds
1.7%
Holding in Top 10
1
Holding in Top 10 Change
+1
Holding in Top 10 Change %
% of All Funds
0.01%
New
20
Increased
50
Reduced
34
Closed
37
Calls
$50K
Puts
$153K
Net Calls
-$103K
Net Calls Change
-$67K

Top Buyers

Rank Fund Capital Flow
1
Fidelity Investments
Fidelity Investments
Massachusetts
+$4.88M
2
Millennium Management
Millennium Management
New York
+$4.69M
3
Goldman Sachs
Goldman Sachs
New York
+$1.58M
4
SCM
Sio Capital Management
New York
+$1.4M
5
Bank of America
Bank of America
North Carolina
+$830K

Top Sellers

Rank Fund Capital Flow
1
Ameriprise
Ameriprise
Minnesota
-$3.65M
2
LGM
Logos Global Management
California
-$3.19M
3
JP Morgan Chase
JP Morgan Chase
New York
-$2.76M
4
WP
Woodline Partners
California
-$2.13M
5
BlackRock
BlackRock
New York
-$1.13M
Name Holding Trade Value Shares
Change 		Change in
Stake
Walleye Capital
26
Walleye Capital
New York
$1.91M -$16.6K -8,274 -1%
Renaissance Technologies
27
Renaissance Technologies
New York
$1.87M -$771K -384,537 -33%
Northern Trust
28
Northern Trust
Illinois
$1.78M -$567K -282,701 -28%
Charles Schwab
29
Charles Schwab
California
$1.75M +$5.29K +2,637 +0.4%
DM
30
Deerfield Management
New York
$1.4M – – –
Deutsche Bank
31
Deutsche Bank
Germany
$1.23M -$51.8K -25,846 -5%
T. Rowe Price Associates
32
T. Rowe Price Associates
Maryland
$1.22M -$33.4K -16,638 -3%
UOC
33
UBS O'Connor
Illinois
$1.18M +$51.9K +25,879 +6%
HWAM
34
Hennion & Walsh Asset Management
New Jersey
$1.16M +$14.2K +7,066 +1%
BOTOTLSJU
35
Board of Trustees of The Leland Stanford Junior University
California
$1.16M – – –
Acadian Asset Management
36
Acadian Asset Management
Massachusetts
$1.13M +$532K +265,219 +130%
RPAM
37
Rhenman & Partners Asset Management
Sweden
$1.1M – – –
Qube Research & Technologies (QRT)
38
Qube Research & Technologies (QRT)
United Kingdom
$1.02M -$627K -312,548 -42%
PHP
39
Parkman Healthcare Partners
Connecticut
$970K +$106K +52,758 +15%
JSSH
40
J. Safra Sarasin Holding
$915K +$254K +126,903 +50%
Wells Fargo
41
Wells Fargo
California
$905K +$58.3K +29,082 +8%
AQR Capital Management
42
AQR Capital Management
Connecticut
$797K +$518K +258,241 +350%
UBS Group
43
UBS Group
Switzerland
$780K +$116K +57,774 +22%
Bank of New York Mellon
44
Bank of New York Mellon
New York
$723K +$24.8K +12,350 +4%
Susquehanna International Group
45
Susquehanna International Group
Pennsylvania
$640K +$135K +67,587 +34%
SSA
46
Schonfeld Strategic Advisors
New York
$639K +$310K +154,849 +139%
N
47
Nuveen
North Carolina
$614K -$183K -91,114 -26%
Royal Bank of Canada
48
Royal Bank of Canada
Ontario, Canada
$588K +$478K +238,365 +3,488%
American Century Companies
49
American Century Companies
Missouri
$507K +$26.1K +13,001 +7%
SPS
50
Susquehanna Portfolio Strategies
Pennsylvania
$499K +$416K +207,715 New
1
2
3 4 5

ANNX Hedge Fund Activity: Q2 2025 in Review

129 of the 7,595 institutional investors tracked by Wall St. Rank reported a position in Annexon (ANNX) for Q2 2025, worth a combined $239M — up 24% from $192M a quarter earlier.

Sellers outnumbered buyers: 37 funds closed out of ANNX and 20 opened new positions — a net loss of 17 holders — while 34 trimmed existing stakes and 50 added.

The largest buyer was Fidelity Investments, adding an estimated $4.88M. The largest seller was Ameriprise, cutting an estimated $3.65M.

  • 129 institutional investors held Annexon (ANNX) as of Q2 2025, down from 146 in Q1 2025.
  • Funds reported $239M of Annexon stock for Q2 2025, up 24% quarter-over-quarter.
  • 20 funds opened new Annexon positions in Q2 2025 and 37 closed out, a net change of -17 holders.
  • The largest Annexon buyer in Q2 2025 was Fidelity Investments, an estimated $4.88M added.
  • The largest Annexon seller in Q2 2025 was Ameriprise, an estimated $3.65M sold.

Based on aggregated 13F filings for Q2 2025.