AnaptysBio
ANAB
166 hedge funds and large institutions have $980M invested in AnaptysBio in 2025 Q3 according to their latest regulatory filings, with 35 funds opening new positions, 43 increasing their positions, 59 reducing their positions, and 15 closing their positions.
133% more first-time investments, than exits
New positions opened: 35 | Existing positions closed: 15
25% more funds holding in top 10
Funds holding in top 10: 4 → 5 (+1)
20% more capital invested
Capital invested by funds: $816M → $980M (+$164M)
13% more funds holding
Funds holding: 147 → 166 (+19)
12.01% less ownership
Funds ownership: 125.13% → 113.12% (-12%)
27% less repeat investments, than reductions
Existing positions increased: 43 | Existing positions reduced: 59
38% less call options, than puts
Call options by funds: $9.37M | Put options by funds: $15.1M
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Millennium Management
New York
|
+$30.2M |
| 2 |
Assenagon Asset Management
Senningerberg,
Luxembourg
|
+$18.9M |
| 3 |
SCM
Soleus Capital Management
Greenwich,
Connecticut
|
+$7M |
| 4 |
D.E. Shaw & Co
New York
|
+$5.44M |
| 5 |
Arrowstreet Capital
Boston,
Massachusetts
|
+$5.04M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
FLAM
First Light Asset Management
Edina,
Minnesota
|
-$58.5M |
| 2 |
UBS Group
Zurich,
Switzerland
|
-$27.5M |
| 3 |
Citigroup
New York
|
-$22.4M |
| 4 |
Bank of America
Charlotte,
North Carolina
|
-$21.8M |
| 5 |
SI
Sofinnova Investments
Menlo Park,
California
|
-$17.9M |
ANAB Hedge Fund Activity: Q3 2025 in Review
166 of the 7,621 institutional investors tracked by Wall St. Rank reported a position in AnaptysBio (ANAB) for Q3 2025, worth a combined $980M — up 20% from $816M a quarter earlier.
Buyers outnumbered sellers: 35 funds opened new ANAB positions and 15 closed out — a net gain of 20 holders — while 43 added to existing stakes and 59 trimmed.
The largest buyer was Millennium Management, adding an estimated $30.2M. The largest seller was First Light Asset Management, cutting an estimated $58.5M.
- 166 institutional investors held AnaptysBio (ANAB) as of Q3 2025, up from 147 in Q2 2025.
- Funds reported $980M of AnaptysBio stock for Q3 2025, up 20% quarter-over-quarter.
- 35 funds opened new AnaptysBio positions in Q3 2025 and 15 closed out, a net change of +20 holders.
- The largest AnaptysBio buyer in Q3 2025 was Millennium Management, an estimated $30.2M added.
- The largest AnaptysBio seller in Q3 2025 was First Light Asset Management, an estimated $58.5M sold.
Based on aggregated 13F filings for Q3 2025.