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AnaptysBio
ANAB

207 hedge funds and large institutions have $1.55B invested in AnaptysBio in 2026 Q1 according to their latest regulatory filings, with 51 funds opening new positions, 58 increasing their positions, 70 reducing their positions, and 20 closing their positions.

New
Increased
Maintained
Reduced
Closed

364% more call options, than puts

Call options by funds: $1.41M | Put options by funds: $305K

155% more first-time investments, than exits

New positions opened: 51 | Existing positions closed: 20

50% more funds holding in top 10

Funds holding in top 10: 4 → 6 (+2)

16% more funds holding

Funds holding: 179 → 207 (+28)

9% more capital invested

Capital invested by funds: $1.42B → $1.55B (+$128M)

7.8% less ownership

Funds ownership: 106.02% → 98.22% (-7.8%)

17% less repeat investments, than reductions

Existing positions increased: 58 | Existing positions reduced: 70

Holders
207
Holders Change
+28
Holders Change %
+15.64%
% of All Funds
2.55%
Holding in Top 10
6
Holding in Top 10 Change
+2
Holding in Top 10 Change %
+50%
% of All Funds
0.07%
New
51
Increased
58
Reduced
70
Closed
20
Calls
$1.41M
Puts
$305K
Net Calls
+$1.11M
Net Calls Change
+$4.48M

Top Buyers

1
AAA
Affinity Asset Advisors
New York
+$26.6M
2
Fidelity Investments
Fidelity Investments
Massachusetts
+$24M
3
Bank of America
Bank of America
North Carolina
+$19.9M
4
SAM
Synergy Asset Management
Washington
+$17.1M
5
ACA
Apis Capital Advisors
New York
+$12.8M

Top Sellers

1
Point72 Asset Management
Point72 Asset Management
Connecticut
-$101M
2
Millennium Management
Millennium Management
New York
-$18.2M
3
WP
Woodline Partners
California
-$8.43M
4
Voloridge Investment Management
Voloridge Investment Management
Florida
-$8.08M
5
SCM
Soleus Capital Management
Connecticut
-$6.94M
Name Holding Trade Value Shares
Change 		Change in
Stake
Qube Research & Technologies (QRT)
26
Qube Research & Technologies (QRT)
United Kingdom
$14.1M +$7.84M +145,771 +134%
SI
27
Sofinnova Investments
California
$13.8M -$2.12M -39,437 -14%
ACA
28
Apis Capital Advisors
New York
$13.2M +$12.8M +238,000 New
Citadel Advisors
29
Citadel Advisors
Florida
$12.9M +$6.67M +123,967 +113%
Charles Schwab
30
Charles Schwab
California
$10.7M -$321K -5,973 -3%
Northern Trust
31
Northern Trust
Illinois
$10.2M +$88K +1,635 +0.9%
Connor, Clark & Lunn Investment Management (CC&L)
32
Connor, Clark & Lunn Investment Management (CC&L)
British Columbia, Canada
$8.79M +$1.94M +36,086 +29%
VFT
33
Vanguard Fiduciary Trust
Pennsylvania
$7.49M +$7.27M +135,082 New
HSBC Holdings
34
HSBC Holdings
United Kingdom
$7.14M +$6.76M +125,717 New
Ensign Peak Advisors
35
Ensign Peak Advisors
Utah
$6.97M -$4.83M -89,821 -42%
Invesco
36
Invesco
Georgia
$6.72M -$156K -2,903 -2%
Victory Capital Management
37
Victory Capital Management
Texas
$6M -$128K -2,380 -2%
BNP Paribas Financial Markets
38
BNP Paribas Financial Markets
France
$5.38M -$3.65M -67,852 -41%
HWM
39
HighMark Wealth Management
Minnesota
$5.22M – – –
NAMI
40
Nomura Asset Management International
Pennsylvania
$5.2M – – –
Renaissance Technologies
41
Renaissance Technologies
New York
$5.04M +$786K +14,600 +19%
Jane Street
42
Jane Street
New York
$4.77M +$85.6K +1,591 +2%
TI
43
Trexquant Investment
Connecticut
$4.72M +$1.42M +26,358 +45%
UBS Group
44
UBS Group
Switzerland
$4.42M +$519K +9,638 +14%
Voloridge Investment Management
45
Voloridge Investment Management
Florida
$4.38M -$8.08M -150,185 -66%
Citigroup
46
Citigroup
New York
$4.07M -$2.53K -47 -0.1%
Marshall Wace
47
Marshall Wace
United Kingdom
$3.77M +$3.66M +68,047 New
GIM
48
Granahan Investment Management
Massachusetts
$3.67M -$3.21M -59,673 -47%
Franklin Resources
49
Franklin Resources
California
$3.65M +$3.54M +65,820 New
Prudential Financial
50
Prudential Financial
New Jersey
$3.55M +$3.45M +64,050 New
1
2
3 4 5

ANAB Hedge Fund Activity: Q1 2026 in Review

207 of the 8,126 institutional investors tracked by Wall St. Rank reported a position in AnaptysBio (ANAB) for Q1 2026, worth a combined $1.55B — up 9% from $1.42B a quarter earlier.

Buyers outnumbered sellers: 51 funds opened new ANAB positions and 20 closed out — a net gain of 31 holders — while 58 added to existing stakes and 70 trimmed.

The largest buyer was Affinity Asset Advisors, adding an estimated $26.6M. The largest seller was Point72 Asset Management, cutting an estimated $101M.

  • 207 institutional investors held AnaptysBio (ANAB) as of Q1 2026, up from 179 in Q4 2025.
  • Funds reported $1.55B of AnaptysBio stock for Q1 2026, up 9% quarter-over-quarter.
  • 51 funds opened new AnaptysBio positions in Q1 2026 and 20 closed out, a net change of +31 holders.
  • The largest AnaptysBio buyer in Q1 2026 was Affinity Asset Advisors, an estimated $26.6M added.
  • The largest AnaptysBio seller in Q1 2026 was Point72 Asset Management, an estimated $101M sold.

Based on aggregated 13F filings for Q1 2026.