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TSHA

Nome Posição Valor negociado Ações
Variação 		Variação na
participação
Avoro Capital Advisors
1
Avoro Capital Advisors
New York
US$ 163 mi +US$ 13 mi +2.188.888 +10%
RA Capital Management
2
RA Capital Management
Massachusetts
US$ 160 mi – – –
Goldman Sachs
3
Goldman Sachs
New York
US$ 155 mi +US$ 2,03 mi +343.473 +2%
BlackRock
4
BlackRock
New York
US$ 141 mi +US$ 13,8 mi +2.326.319 +13%
Vestal Point Capital
5
Vestal Point Capital
New York
US$ 132 mi +US$ 8,37 mi +1.415.000 +8%
Morgan Stanley
6
Morgan Stanley
New York
US$ 112 mi -US$ 8,75 mi -1.477.892 -8%
RTW Investments
7
RTW Investments
New York
US$ 92,3 mi -US$ 710 mil -119.990 -0,9%
Fidelity Investments
8
Fidelity Investments
Massachusetts
US$ 90,8 mi -US$ 5,83 mi -984.842 -7%
Vanguard Capital Management
9
Vanguard Capital Management
Pennsylvania
US$ 85 mi +US$ 13,3 mi +2.247.093 +22%
State Street
10
State Street
Massachusetts
US$ 77,8 mi +US$ 1,26 mi +212.842 +2%
SL
11
Siren LLC
Connecticut
US$ 67,1 mi +US$ 6,02 mi +1.016.666 +12%
Octagon Capital Advisors
12
Octagon Capital Advisors
New York
US$ 66 mi +US$ 4,93 mi +833.333 +9%
Geode Capital Management
13
Geode Capital Management
Massachusetts
US$ 44,7 mi +US$ 6,09 mi +1.028.439 +19%
Polar Capital Holdings
14
Polar Capital Holdings
United Kingdom
US$ 34,8 mi -US$ 3,18 mi -537.207 -10%
MPM BioImpact
15
MPM BioImpact
Massachusetts
US$ 30,6 mi +US$ 26,6 mi +4.500.000 Nova
D.E. Shaw & Co
16
D.E. Shaw & Co
New York
US$ 30 mi -US$ 170 mil -28.649 -0,6%
BBA
17
Baker Bros. Advisors
New York
US$ 27,3 mi – – –
Wellington Management Group
18
Wellington Management Group
Massachusetts
US$ 27,1 mi +US$ 19,8 mi +3.349.244 +535%
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
19
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Ontario, Canada
US$ 26,5 mi +US$ 5,93 mi +1.002.200 +35%
GGI
20
GordonMD Global Investments
California
US$ 24,5 mi -US$ 85 mil -14.365 -2%
Casdin Capital
21
Casdin Capital
New York
US$ 22,1 mi – – –
Vanguard Portfolio Management
22
Vanguard Portfolio Management
Pennsylvania
US$ 21,4 mi +US$ 6,61 mi +1.117.511 +55%
ADAR1 Capital Management
23
ADAR1 Capital Management
Texas
US$ 20,7 mi +US$ 361 mil +61.037 +2%
Pictet Asset Management
24
Pictet Asset Management
Switzerland
US$ 18,9 mi +US$ 16,3 mi +2.751.383 +14.243%
Aberdeen Group
25
Aberdeen Group
United Kingdom
US$ 15,8 mi +US$ 7,73 mi +1.306.089 +128%
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