Two Sigma Securities’s Spruce Biosciences SPRB Stock Holding History

Two Sigma Securities’s Portfolio SPRB Stock Details SPRB Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2025 Q2	–	Sell	-636	Closed	-$13.8K	–	2238
2025 Q1	$13.8K	Buy	+636	New	+$17.7K	﹤0.01%	1169
2024 Q2	–	Sell	-347	Closed	-$20.4K	–	3813
2024 Q1	$20.4K	Buy	+347	New	+$88.2K	﹤0.01%	2670
2022 Q1	–	Sell	-383	Closed	-$128K	–	2602
2021 Q4	$128K	Buy	+383	New	+$114K	0.01%	1145

Other funds holding SPRB

Acadian Asset Management Boston, Massachusetts $70.5B AUM 36% 1-Year Est. Return

Ikarian Capital Dallas, Texas $1.23B AUM 600.17% 1-Year Est. Return

CSC

Caldwell Sutter Capital Sausalito, California $246M AUM 23.62% 1-Year Est. Return

Two Sigma Securities's SPRB Position: Q2 2025 in Review

Two Sigma Securities sold out of Spruce Biosciences (SPRB) in Q2 2025, closing a stake of 636 shares — an estimated $13.8K sold.

Two Sigma Securities first reported a position in SPRB in Q4 2021 and held it in 3 quarters. The position peaked at $128K in Q4 2021. 3 funds tracked by Wall St. Rank hold SPRB as of Q2 2025.

Two Sigma Securities reported no remaining Spruce Biosciences position as of Q2 2025 after selling out during the quarter.
Two Sigma Securities sold 636 Spruce Biosciences shares in Q2 2025, an estimated $13.8K.
Two Sigma Securities first reported a position in Spruce Biosciences in Q4 2021 and held it in 3 quarters.
Two Sigma Securities's Spruce Biosciences position peaked at $128K in Q4 2021.
3 funds tracked by Wall St. Rank held Spruce Biosciences as of Q2 2025.

Based on Two Sigma Securities's 13F filing for Q2 2025, filed 14 Aug 2025.