Two Sigma Investments
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Two Sigma Investments’s Zymeworks ZYME Stock Holding History

Two Sigma Investments’s Portfolio ZYME Stock Details ZYME Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q2 		$1.88M Buy
+71,874
New +$1.83M ﹤0.01% 3043
2024
Q2 		– Sell
-26,430
Closed -$278K – 3386
2024
Q1 		$278K Sell
26,430
-9,870
-27% -$110K ﹤0.01% 2592
2023
Q4 		$377K Sell
36,300
-12,600
-26% -$100K ﹤0.01% 2595
2023
Q3 		$310K Sell
48,900
-10,300
-17% -$76.1K ﹤0.01% 2480
2023
Q2 		$511K Buy
59,200
+15,600
+36% +$140K ﹤0.01% 2322
2023
Q1 		$394K Buy
43,600
+5,888
+16% +$51.3K ﹤0.01% 2308
2022
Q4 		$296K Buy
+37,712
New +$265K ﹤0.01% 2253
2022
Q2 		– Sell
-791,148
Closed -$5.18M – 3002
2022
Q1 		$5.18M Buy
+791,148
New +$7.05M 0.02% 911
2021
Q4 		– Sell
-18,532
Closed -$538K – 4982
2021
Q3 		$538K Buy
+18,532
New +$616K ﹤0.01% 3189
2021
Q2 		– Sell
-123,748
Closed -$3.91M – 4656
2021
Q1 		$3.91M Buy
123,748
+59,600
+93% +$2.42M 0.01% 1225
2020
Q4 		$3.03M Buy
+64,148
New +$2.98M 0.01% 1228
2020
Q3 		– Sell
-130,950
Closed -$4.72M – 3636
2020
Q2 		$4.72M Sell
130,950
-140,964
-52% -$5.19M 0.02% 662
2020
Q1 		$9.64M Sell
271,914
-107,042
-28% -$4.38M 0.08% 268
2019
Q4 		$17.2M Buy
378,956
+238,535
+170% +$8.67M 0.05% 413
2019
Q3 		$3.48M Sell
140,421
-8,479
-6% -$212K 0.01% 1065
2019
Q2 		$3.28M Buy
148,900
+86,407
+138% +$1.59M 0.01% 1130
2019
Q1 		$1.01M Buy
62,493
+46,363
+287% +$719K ﹤0.01% 1820
2018
Q4 		$237K Sell
16,130
-46,483
-74% -$610K ﹤0.01% 2607
2018
Q3 		$983K Buy
62,613
+42,478
+211% +$608K ﹤0.01% 1995
2018
Q2 		$298K Buy
+20,135
New +$312K ﹤0.01% 2943

Other funds holding ZYME

EC
EcoR1 Capital San Francisco, California $2.06B AUM 215.32% 1-Year Est. Return
RCMNY
Rubric Capital Management (New York) New York $10.9B AUM 70.31% 1-Year Est. Return
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
PA
Perceptive Advisors New York $6.66B AUM 360.84% 1-Year Est. Return
BI
BVF Inc San Francisco, California $3.91B AUM 304.52% 1-Year Est. Return
Morgan Stanley
Morgan Stanley New York $1.89T AUM 35.08% 1-Year Est. Return
BNP Paribas Asset Management
BNP Paribas Asset Management Paris, France $99.8B AUM 45.22% 1-Year Est. Return
Vanguard Capital Management
Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM
Assenagon Asset Management
Assenagon Asset Management Senningerberg, Luxembourg $80.2B AUM 50.56% 1-Year Est. Return
NI
Nextech Invest Zurich, Switzerland $2.11B AUM 413.84% 1-Year Est. Return

Two Sigma Investments's ZYME Position: Q2 2026 in Review

Two Sigma Investments opened a new position in Zymeworks (ZYME) in Q2 2026: 71,874 shares worth $1.88M. The stake represents ﹤0.01% of the portfolio and ranks #3043 among its holdings. This is a return to the name: Two Sigma Investments previously reported a position in ZYME as recently as Q1 2024.

Two Sigma Investments first reported a position in ZYME in Q2 2018 and has held it in 20 quarters since. The position peaked at $17.2M in Q4 2019. 203 funds tracked by Wall St. Rank hold ZYME as of Q2 2026.

  • Two Sigma Investments held 71,874 shares of Zymeworks worth $1.88M as of Q2 2026.
  • Zymeworks was a new Two Sigma Investments position in Q2 2026.
  • Zymeworks made up ﹤0.01% of Two Sigma Investments's portfolio in Q2 2026, its #3043 holding.
  • Two Sigma Investments first reported a position in Zymeworks in Q2 2018 and has held it in 20 quarters since.
  • Two Sigma Investments's Zymeworks position peaked at $17.2M in Q4 2019.
  • 203 funds tracked by Wall St. Rank held Zymeworks as of Q2 2026.

Based on Two Sigma Investments's 13F filing for Q2 2026, filed 14 Aug 2026.