Two Sigma Investments
SPRB

Two Sigma Investments’s Spruce Biosciences SPRB Stock Holding History

Two Sigma Investments’s Portfolio SPRB Stock Details SPRB Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2025
Q2 		– Sell
-274
Closed -$5.96K – 3663
2025
Q1 		$5.96K Sell
274
-1
-0.4% -$28 ﹤0.01% 3143
2024
Q4 		$8.66K Sell
275
-37
-12% -$1.36K ﹤0.01% 3137
2024
Q3 		$11.1K Sell
312
-69
-18% -$2.53K ﹤0.01% 3045
2024
Q2 		$14.8K Sell
381
-1,259
-77% -$67.5K ﹤0.01% 2944
2024
Q1 		$96.7K Sell
1,640
-151
-8% -$38.4K ﹤0.01% 2836
2023
Q4 		$394K Sell
1,791
-174
-9% -$20.1K ﹤0.01% 2576
2023
Q3 		$333K Sell
1,965
-1,077
-35% -$182K ﹤0.01% 2448
2023
Q2 		$490K Buy
3,042
+866
+40% +$145K ﹤0.01% 2338
2023
Q1 		$361K Buy
+2,176
New +$404K ﹤0.01% 2343
2021
Q4 		– Sell
-392
Closed -$177K – 5002
2021
Q3 		$177K Buy
392
+232
+145% +$146K ﹤0.01% 3992
2021
Q2 		$134K Buy
+160
New +$171K ﹤0.01% 3865

Other funds holding SPRB

Acadian Asset Management
Acadian Asset Management Boston, Massachusetts $70.5B AUM 36% 1-Year Est. Return
IC
Ikarian Capital Dallas, Texas $1.23B AUM 600.17% 1-Year Est. Return
CSC
Caldwell Sutter Capital Sausalito, California $246M AUM 23.62% 1-Year Est. Return

Two Sigma Investments's SPRB Position: Q2 2025 in Review

Two Sigma Investments sold out of Spruce Biosciences (SPRB) in Q2 2025, closing a stake of 274 shares — an estimated $5.96K sold.

Two Sigma Investments first reported a position in SPRB in Q2 2021 and held it in 11 quarters. The position peaked at $490K in Q2 2023. 3 funds tracked by Wall St. Rank hold SPRB as of Q2 2025.

  • Two Sigma Investments reported no remaining Spruce Biosciences position as of Q2 2025 after selling out during the quarter.
  • Two Sigma Investments sold 274 Spruce Biosciences shares in Q2 2025, an estimated $5.96K.
  • Two Sigma Investments first reported a position in Spruce Biosciences in Q2 2021 and held it in 11 quarters.
  • Two Sigma Investments's Spruce Biosciences position peaked at $490K in Q2 2023.
  • 3 funds tracked by Wall St. Rank held Spruce Biosciences as of Q2 2025.

Based on Two Sigma Investments's 13F filing for Q2 2025, filed 14 Aug 2025.