Two Sigma Investments
OPK icon

Two Sigma Investments’s Opko Health OPK Stock Holding History

Two Sigma Investments’s Portfolio OPK Stock Details OPK Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$194K Sell
170,000
-564,747
-77% -$695K ﹤0.01% 4288
2025
Q4 		$926K Sell
734,747
-520,900
-41% -$725K ﹤0.01% 2969
2025
Q3 		$1.95M Sell
1,255,647
-581,100
-32% -$798K ﹤0.01% 2144
2025
Q2 		$2.42M Buy
1,836,747
+190,972
+12% +$261K ﹤0.01% 1699
2025
Q1 		$2.73M Sell
1,645,775
-1,792
-0.1% -$2.95K 0.01% 1533
2024
Q4 		$2.42M Buy
1,647,567
+949,671
+136% +$1.45M 0.01% 1587
2024
Q3 		$1.04M Buy
697,896
+91,408
+15% +$136K ﹤0.01% 2097
2024
Q2 		$758K Sell
606,488
-1,028,199
-63% -$1.33M ﹤0.01% 2142
2024
Q1 		$1.96M Buy
1,634,687
+665,872
+69% +$666K ﹤0.01% 1493
2023
Q4 		$1.46M Sell
968,815
-471,367
-33% -$681K ﹤0.01% 1835
2023
Q3 		$2.3M Sell
1,440,182
-154,283
-10% -$281K 0.01% 1294
2023
Q2 		$3.46M Sell
1,594,465
-330,009
-17% -$516K 0.01% 1105
2023
Q1 		$2.81M Sell
1,924,474
-344,542
-15% -$443K 0.01% 1183
2022
Q4 		$2.84M Sell
2,269,016
-618,353
-21% -$974K 0.01% 1132
2022
Q3 		$5.46M Buy
2,887,369
+1,191,429
+70% +$2.82M 0.02% 722
2022
Q2 		$4.29M Buy
+1,695,940
New +$4.95M 0.01% 842
2021
Q4 		– Sell
-17,804
Closed -$65K – 4706
2021
Q3 		$65K Hold
17,804
– – ﹤0.01% 4129
2021
Q2 		$72K Sell
17,804
-25,900
-59% -$102K ﹤0.01% 3933
2021
Q1 		$187K Buy
+43,704
New +$209K ﹤0.01% 3642
2020
Q4 		– Sell
-1,107,710
Closed -$4.09M – 3639
2020
Q3 		$4.09M Buy
1,107,710
+59,645
+6% +$252K 0.01% 894
2020
Q2 		$3.57M Sell
1,048,065
-1,861,658
-64% -$4.17M 0.02% 809
2020
Q1 		$3.9M Buy
2,909,723
+347,480
+14% +$544K 0.03% 620
2019
Q4 		$3.77M Buy
2,562,243
+2,398,766
+1,467% +$4.02M 0.01% 1136
2019
Q3 		$342K Sell
163,477
-756,677
-82% -$1.55M ﹤0.01% 2862
2019
Q2 		$2.25M Buy
920,154
+656,802
+249% +$1.43M 0.01% 1375
2019
Q1 		$687K Buy
+263,352
New +$797K ﹤0.01% 2058
2016
Q4 		– Sell
-158,901
Closed -$1.68M – 3410
2016
Q3 		$1.68M Buy
+158,901
New +$1.58M 0.01% 1592
2016
Q2 		– Sell
-15,920
Closed -$165K – 3140
2016
Q1 		$165K Buy
+15,920
New +$145K ﹤0.01% 2623
2015
Q4 		– Sell
-752,431
Closed -$6.33M – 2901
2015
Q3 		$6.33M Sell
752,431
-780,667
-51% -$10.3M 0.03% 461
2015
Q2 		$24.7M Buy
1,533,098
+1,516,803
+9,308% +$23.6M 0.12% 213
2015
Q1 		$231K Buy
+16,295
New +$212K ﹤0.01% 2430

Other funds holding OPK

RCMNY
Rubric Capital Management (New York) New York $9.44B AUM 68.42% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
VPM
Vanguard Portfolio Management Malvern, Pennsylvania $1.91T AUM
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
Geode Capital Management
Geode Capital Management Boston, Massachusetts $1.61T AUM 30.72% 1-Year Est. Return
State Street
State Street Boston, Massachusetts $2.9T AUM 29.55% 1-Year Est. Return
Goldman Sachs
Goldman Sachs New York $871B AUM 31.28% 1-Year Est. Return
UBS Group
UBS Group Zurich, Switzerland $666B AUM 30.12% 1-Year Est. Return
WCM
Whitefort Capital Management New York $339M AUM 52.48% 1-Year Est. Return
Northern Trust
Northern Trust Chicago, Illinois $757B AUM 28.64% 1-Year Est. Return

Two Sigma Investments's OPK Position: Q1 2026 in Review

Two Sigma Investments reduced its Opko Health (OPK) stake by 77% in Q1 2026, selling an estimated $695K and leaving 170,000 shares worth $194K. The position accounts for ﹤0.01% of the portfolio, ranked #4288.

Two Sigma Investments first reported a position in OPK in Q1 2015 and has held it in 31 quarters since. The position peaked at $24.7M in Q2 2015. 235 funds tracked by Wall St. Rank hold OPK as of Q1 2026.

  • Two Sigma Investments held 170,000 shares of Opko Health worth $194K as of Q1 2026.
  • Two Sigma Investments sold 564,747 Opko Health shares in Q1 2026, an estimated $695K.
  • Opko Health made up ﹤0.01% of Two Sigma Investments's portfolio in Q1 2026, its #4288 holding.
  • Two Sigma Investments first reported a position in Opko Health in Q1 2015 and has held it in 31 quarters since.
  • Two Sigma Investments's Opko Health position peaked at $24.7M in Q2 2015.
  • 235 funds tracked by Wall St. Rank held Opko Health as of Q1 2026.

Based on Two Sigma Investments's 13F filing for Q1 2026, filed 15 May 2026.