Two Sigma Investments
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Two Sigma Investments’s Immunome IMNM Stock Holding History

Two Sigma Investments’s Portfolio IMNM Stock Details IMNM Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2025
Q3 		– Sell
-26,654
Closed -$248K – 3781
2025
Q2 		$248K Sell
26,654
-63,070
-70% -$517K ﹤0.01% 2853
2025
Q1 		$604K Sell
89,724
-64,743
-42% -$621K ﹤0.01% 2438
2024
Q4 		$1.64M Buy
+154,467
New +$1.87M ﹤0.01% 1855
2024
Q3 		– Sell
-107,846
Closed -$1.3M – 3223
2024
Q2 		$1.3M Buy
+107,846
New +$1.69M ﹤0.01% 1834
2021
Q3 		– Sell
-29,516
Closed -$511K – 4459
2021
Q2 		$511K Buy
+29,516
New +$652K ﹤0.01% 3079

Other funds holding IMNM

Fidelity Investments
Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return
T. Rowe Price Investment Management
T. Rowe Price Investment Management Baltimore, Maryland $145B AUM 22.78% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
RG
Redmile Group San Francisco, California $1.51B AUM 164.17% 1-Year Est. Return
Vanguard Group
Vanguard Group Malvern, Pennsylvania $6.9T AUM 27.45% 1-Year Est. Return
Point72 Asset Management
Point72 Asset Management Stamford, Connecticut $78.1B AUM 55.25% 1-Year Est. Return
ES
Enavate Sciences Menlo Park, California $352M AUM 220.14% 1-Year Est. Return
EC
EcoR1 Capital San Francisco, California $2.36B AUM 204.53% 1-Year Est. Return
T. Rowe Price Associates
T. Rowe Price Associates Baltimore, Maryland $865B AUM 30.76% 1-Year Est. Return
OM
Opaleye Management Boston, Massachusetts $759M AUM 124.8% 1-Year Est. Return

Two Sigma Investments's IMNM Position: Q3 2025 in Review

Two Sigma Investments sold out of Immunome (IMNM) in Q3 2025, closing a stake of 26,654 shares — an estimated $248K sold.

Two Sigma Investments first reported a position in IMNM in Q2 2021 and held it in 5 quarters. The position peaked at $1.64M in Q4 2024. 153 funds tracked by Wall St. Rank hold IMNM as of Q3 2025.

  • Two Sigma Investments reported no remaining Immunome position as of Q3 2025 after selling out during the quarter.
  • Two Sigma Investments sold 26,654 Immunome shares in Q3 2025, an estimated $248K.
  • Two Sigma Investments first reported a position in Immunome in Q2 2021 and held it in 5 quarters.
  • Two Sigma Investments's Immunome position peaked at $1.64M in Q4 2024.
  • 153 funds tracked by Wall St. Rank held Immunome as of Q3 2025.

Based on Two Sigma Investments's 13F filing for Q3 2025, filed 14 Nov 2025.