Two Sigma Investments
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Two Sigma Investments’s Arrowhead Research ARWR Stock Holding History

Two Sigma Investments’s Portfolio ARWR Stock Details ARWR Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$2.24M Buy
+35,800
New +$2.27M ﹤0.01% 2673
2025
Q3 		– Sell
-133,403
Closed -$2.11M – 3648
2025
Q2 		$2.11M Sell
133,403
-701,771
-84% -$10.1M ﹤0.01% 1804
2025
Q1 		$10.6M Buy
835,174
+40,801
+5% +$742K 0.02% 746
2024
Q4 		$14.9M Buy
794,373
+586,062
+281% +$12.1M 0.03% 588
2024
Q3 		$4.03M Buy
208,311
+19,998
+11% +$488K 0.01% 1185
2024
Q2 		$4.89M Buy
188,313
+155,011
+465% +$3.81M 0.01% 1019
2024
Q1 		$952K Buy
33,302
+7,400
+29% +$237K ﹤0.01% 1987
2023
Q4 		$793K Sell
25,902
-242,032
-90% -$6.43M ﹤0.01% 2211
2023
Q3 		$7.2M Sell
267,934
-43,106
-14% -$1.32M 0.02% 726
2023
Q2 		$11.1M Buy
311,040
+220,740
+244% +$7.61M 0.03% 598
2023
Q1 		$2.29M Buy
90,300
+76,355
+548% +$2.4M 0.01% 1298
2022
Q4 		$566K Buy
+13,945
New +$462K ﹤0.01% 1969
2022
Q3 		– Sell
-42,886
Closed -$1.51M – 2464
2022
Q2 		$1.51M Buy
42,886
+36,257
+547% +$1.36M 0.01% 1341
2022
Q1 		$305K Buy
+6,629
New +$328K ﹤0.01% 2208
2021
Q3 		– Sell
-74,200
Closed -$6.14M – 4220
2021
Q2 		$6.14M Buy
74,200
+22,338
+43% +$1.66M 0.01% 1077
2021
Q1 		$3.44M Buy
+51,862
New +$4.02M 0.01% 1299
2020
Q3 		– Sell
-31,787
Closed -$1.37M – 3060
2020
Q2 		$1.37M Sell
31,787
-540,616
-94% -$19.1M 0.01% 1311
2020
Q1 		$16.5M Buy
572,403
+415,952
+266% +$16.8M 0.13% 156
2019
Q4 		$9.92M Buy
+156,451
New +$7.76M 0.03% 623
2018
Q4 		– Sell
-235,216
Closed -$4.51M – 2967
2018
Q3 		$4.51M Buy
235,216
+46,852
+25% +$769K 0.01% 997
2018
Q2 		$2.56M Buy
+188,364
New +$1.76M 0.01% 1456
2018
Q1 		– Sell
-39,726
Closed -$146K – 3109
2017
Q4 		$146K Buy
+39,726
New +$148K ﹤0.01% 2967
2014
Q2 		– Sell
-106,599
Closed -$1.75M – 2133
2014
Q1 		$1.75M Buy
106,599
+92,309
+646% +$1.62M 0.01% 992
2013
Q4 		$155K Buy
+14,290
New +$114K ﹤0.01% 2041

Other funds holding ARWR

BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
ACA
Avoro Capital Advisors New York $10.2B AUM 149.19% 1-Year Est. Return
Fidelity Investments
Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return
VPM
Vanguard Portfolio Management Malvern, Pennsylvania $1.91T AUM
State Street
State Street Boston, Massachusetts $2.9T AUM 29.55% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
Geode Capital Management
Geode Capital Management Boston, Massachusetts $1.61T AUM 30.72% 1-Year Est. Return
FAM
Fred Alger Management New York $22.8B AUM 64.63% 1-Year Est. Return
Invesco
Invesco Atlanta, Georgia $1.02T AUM 30.18% 1-Year Est. Return
VPC
Vestal Point Capital New York $3.58B AUM 189.12% 1-Year Est. Return

Two Sigma Investments's ARWR Position: Q1 2026 in Review

Two Sigma Investments opened a new position in Arrowhead Research (ARWR) in Q1 2026: 35,800 shares worth $2.24M. The stake represents ﹤0.01% of the portfolio and ranks #2673 among its holdings. This is a return to the name: Two Sigma Investments previously reported a position in ARWR as recently as Q2 2025.

Two Sigma Investments first reported a position in ARWR in Q4 2013 and has held it in 24 quarters since. The position peaked at $16.5M in Q1 2020. 436 funds tracked by Wall St. Rank hold ARWR as of Q1 2026.

  • Two Sigma Investments held 35,800 shares of Arrowhead Research worth $2.24M as of Q1 2026.
  • Arrowhead Research was a new Two Sigma Investments position in Q1 2026.
  • Arrowhead Research made up ﹤0.01% of Two Sigma Investments's portfolio in Q1 2026, its #2673 holding.
  • Two Sigma Investments first reported a position in Arrowhead Research in Q4 2013 and has held it in 24 quarters since.
  • Two Sigma Investments's Arrowhead Research position peaked at $16.5M in Q1 2020.
  • 436 funds tracked by Wall St. Rank held Arrowhead Research as of Q1 2026.

Based on Two Sigma Investments's 13F filing for Q1 2026, filed 15 May 2026.