Two Sigma Advisers
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Two Sigma Advisers’s Zymeworks ZYME Stock Holding History

Two Sigma Advisers’s Portfolio ZYME Stock Details ZYME Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		– Sell
-31,415
Closed -$827K – 2224
2025
Q4 		$827K Buy
+31,415
New +$685K ﹤0.01% 1583
2023
Q3 		– Sell
-13,200
Closed -$114K – 2603
2023
Q2 		$114K Buy
+13,200
New +$118K ﹤0.01% 2194
2022
Q3 		– Sell
-71,600
Closed -$379K – 2759
2022
Q2 		$379K Sell
71,600
-232,700
-76% -$1.41M ﹤0.01% 2041
2022
Q1 		$1.99M Buy
304,300
+269,300
+769% +$2.4M 0.01% 1259
2021
Q4 		$574K Sell
35,000
-60,400
-63% -$1.26M ﹤0.01% 1857
2021
Q3 		$2.77M Sell
95,400
-43,100
-31% -$1.43M 0.01% 1079
2021
Q2 		$4.8M Sell
138,500
-185,400
-57% -$5.88M 0.01% 879
2021
Q1 		$10.2M Sell
323,900
-28,000
-8% -$1.14M 0.03% 567
2020
Q4 		$16.6M Sell
351,900
-36,200
-9% -$1.68M 0.04% 397
2020
Q3 		$18.1M Sell
388,100
-146,200
-27% -$5.02M 0.05% 345
2020
Q2 		$19.3M Buy
534,300
+60,100
+13% +$2.21M 0.06% 336
2020
Q1 		$16.8M Buy
474,200
+187,700
+66% +$7.68M 0.06% 323
2019
Q4 		$13M Buy
286,500
+252,200
+735% +$9.16M 0.03% 504
2019
Q3 		$851K Buy
34,300
+13,500
+65% +$338K ﹤0.01% 1505
2019
Q2 		$458K Buy
+20,800
New +$382K ﹤0.01% 1848

Other funds holding ZYME

EC
EcoR1 Capital San Francisco, California $2.36B AUM 204.53% 1-Year Est. Return
RCMNY
Rubric Capital Management (New York) New York $9.44B AUM 68.42% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
BI
BVF Inc San Francisco, California $3.14B AUM 249.53% 1-Year Est. Return
PA
Perceptive Advisors New York $5.12B AUM 314.02% 1-Year Est. Return
Morgan Stanley
Morgan Stanley New York $1.66T AUM 25.57% 1-Year Est. Return
BNP Paribas Asset Management
BNP Paribas Asset Management Paris, France $86.1B AUM 29.11% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
Citadel Advisors
Citadel Advisors Miami, Florida $618B AUM 30.34% 1-Year Est. Return
Dimensional Fund Advisors
Dimensional Fund Advisors Austin, Texas $481B AUM 30.42% 1-Year Est. Return

Two Sigma Advisers's ZYME Position: Q1 2026 in Review

Two Sigma Advisers sold out of Zymeworks (ZYME) in Q1 2026, closing a stake of 31,415 shares — an estimated $827K sold.

Two Sigma Advisers first reported a position in ZYME in Q2 2019 and held it in 15 quarters. The position peaked at $19.3M in Q2 2020. 211 funds tracked by Wall St. Rank hold ZYME as of Q1 2026.

  • Two Sigma Advisers reported no remaining Zymeworks position as of Q1 2026 after selling out during the quarter.
  • Two Sigma Advisers sold 31,415 Zymeworks shares in Q1 2026, an estimated $827K.
  • Two Sigma Advisers first reported a position in Zymeworks in Q2 2019 and held it in 15 quarters.
  • Two Sigma Advisers's Zymeworks position peaked at $19.3M in Q2 2020.
  • 211 funds tracked by Wall St. Rank held Zymeworks as of Q1 2026.

Based on Two Sigma Advisers's 13F filing for Q1 2026.