Two Sigma Advisers
SPRB

Two Sigma Advisers’s Spruce Biosciences SPRB Stock Holding History

Two Sigma Advisers’s Portfolio SPRB Stock Details SPRB Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2025
Q2 		– Sell
-163
Closed -$3.54K – 2598
2025
Q1 		$3.54K Sell
163
-21
-11% -$585 ﹤0.01% 2359
2024
Q4 		$5.8K Sell
184
-177
-49% -$6.49K ﹤0.01% 2329
2024
Q3 		$12.9K Sell
361
-248
-41% -$9.08K ﹤0.01% 2256
2024
Q2 		$23.7K Sell
609
-595
-49% -$31.9K ﹤0.01% 2394
2024
Q1 		$71K Sell
1,204
-71
-6% -$18.1K ﹤0.01% 2326
2023
Q4 		$280K Sell
1,275
-9
-0.7% -$1.04K ﹤0.01% 2125
2023
Q3 		$218K Sell
1,284
-1,916
-60% -$323K ﹤0.01% 2080
2023
Q2 		$516K Buy
3,200
+2,699
+539% +$451K ﹤0.01% 1792
2023
Q1 		$83.1K Buy
+501
New +$93.1K ﹤0.01% 2402
2021
Q4 		– Sell
-256
Closed -$115K – 2837
2021
Q3 		$115K Buy
+256
New +$161K ﹤0.01% 2312

Other funds holding SPRB

Acadian Asset Management
Acadian Asset Management Boston, Massachusetts $84.2B AUM 55.88% 1-Year Est. Return
IC
Ikarian Capital Dallas, Texas $928M AUM 596.14% 1-Year Est. Return
CSC
Caldwell Sutter Capital Sausalito, California $265M AUM 30.15% 1-Year Est. Return

Two Sigma Advisers's SPRB Position: Q2 2025 in Review

Two Sigma Advisers sold out of Spruce Biosciences (SPRB) in Q2 2025, closing a stake of 163 shares — an estimated $3.54K sold.

Two Sigma Advisers first reported a position in SPRB in Q3 2021 and held it in 10 quarters. The position peaked at $516K in Q2 2023. 3 funds tracked by Wall St. Rank hold SPRB as of Q2 2025.

  • Two Sigma Advisers reported no remaining Spruce Biosciences position as of Q2 2025 after selling out during the quarter.
  • Two Sigma Advisers sold 163 Spruce Biosciences shares in Q2 2025, an estimated $3.54K.
  • Two Sigma Advisers first reported a position in Spruce Biosciences in Q3 2021 and held it in 10 quarters.
  • Two Sigma Advisers's Spruce Biosciences position peaked at $516K in Q2 2023.
  • 3 funds tracked by Wall St. Rank held Spruce Biosciences as of Q2 2025.

Based on Two Sigma Advisers's 13F filing for Q2 2025, filed 14 Aug 2025.