Two Sigma Advisers
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Two Sigma Advisers’s ProQR Therapeutics PRQR Stock Holding History

Two Sigma Advisers’s Portfolio PRQR Stock Details PRQR Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		– Sell
-452,400
Closed -$914K – 1623
2025
Q4 		$914K Buy
452,400
+223,800
+98% +$523K ﹤0.01% 1523
2025
Q3 		$487K Buy
228,600
+88,300
+63% +$193K ﹤0.01% 1776
2025
Q2 		$286K Buy
140,300
+79,300
+130% +$129K ﹤0.01% 1979
2025
Q1 		$81.1K Buy
61,000
+31,800
+109% +$67.7K ﹤0.01% 2264
2024
Q4 		$77.4K Sell
29,200
-58,300
-67% -$185K ﹤0.01% 2249
2024
Q3 		$159K Sell
87,500
-44,000
-33% -$82.6K ﹤0.01% 2114
2024
Q2 		$218K Sell
131,500
-30,500
-19% -$59.2K ﹤0.01% 2180
2024
Q1 		$371K Sell
162,000
-6,700
-4% -$14.3K ﹤0.01% 1993
2023
Q4 		$334K Sell
168,700
-59,500
-26% -$91.4K ﹤0.01% 2072
2023
Q3 		$297K Sell
228,200
-233,000
-51% -$367K ﹤0.01% 1982
2023
Q2 		$747K Buy
461,200
+87,200
+23% +$170K ﹤0.01% 1654
2023
Q1 		$797K Buy
374,000
+122,500
+49% +$375K ﹤0.01% 1745
2022
Q4 		$931K Buy
251,500
+78,200
+45% +$102K ﹤0.01% 1598
2022
Q3 		$129K Buy
173,300
+117,400
+210% +$94.3K ﹤0.01% 2275
2022
Q2 		$43K Sell
55,900
-75,800
-58% -$56.5K ﹤0.01% 2494
2022
Q1 		$119K Buy
+131,700
New +$441K ﹤0.01% 2480
2021
Q4 		– Sell
-12,700
Closed -$106K – 2770
2021
Q3 		$106K Buy
+12,700
New +$83K ﹤0.01% 2320
2020
Q3 		– Sell
-13,600
Closed -$83K – 2593
2020
Q2 		$83K Buy
+13,600
New +$73.5K ﹤0.01% 2382

Other funds holding PRQR

Adage Capital Partners
Adage Capital Partners Boston, Massachusetts $64.8B AUM 42.7% 1-Year Est. Return
PFM
Privium Fund Management Amsterdam, Netherlands $480M AUM 77.45% 1-Year Est. Return
Aberdeen Group
Aberdeen Group Edinburgh, United Kingdom $61.9B AUM 29.81% 1-Year Est. Return
AAA
Affinity Asset Advisors New York $1.94B AUM 374.45% 1-Year Est. Return
SCM
Sio Capital Management New York $697M AUM 79.73% 1-Year Est. Return
DCM
DAFNA Capital Management Los Angeles, California $440M AUM 109.12% 1-Year Est. Return
KCM
Kynam Capital Management Princeton, New Jersey $1.62B AUM 138.67% 1-Year Est. Return
IC
Ikarian Capital Dallas, Texas $1.23B AUM 600.17% 1-Year Est. Return
Morgan Stanley
Morgan Stanley New York $1.66T AUM 25.57% 1-Year Est. Return
PIM
Platinum Investment Management Sydney Australia 2000, Australia $397M AUM 63.96% 1-Year Est. Return

Two Sigma Advisers's PRQR Position: Q1 2026 in Review

Two Sigma Advisers sold out of ProQR Therapeutics (PRQR) in Q1 2026, closing a stake of 452,400 shares — an estimated $914K sold.

Two Sigma Advisers first reported a position in PRQR in Q2 2020 and held it in 18 quarters. The position peaked at $931K in Q4 2022. 69 funds tracked by Wall St. Rank hold PRQR as of Q1 2026.

  • Two Sigma Advisers reported no remaining ProQR Therapeutics position as of Q1 2026 after selling out during the quarter.
  • Two Sigma Advisers sold 452,400 ProQR Therapeutics shares in Q1 2026, an estimated $914K.
  • Two Sigma Advisers first reported a position in ProQR Therapeutics in Q2 2020 and held it in 18 quarters.
  • Two Sigma Advisers's ProQR Therapeutics position peaked at $931K in Q4 2022.
  • 69 funds tracked by Wall St. Rank held ProQR Therapeutics as of Q1 2026.

Based on Two Sigma Advisers's 13F filing for Q1 2026.