We are live on ! Find out more
SL

Siren LLC Portfolio holdings

AUM $3.61B
1-Year Est. Return 203.3%
This Fund
S&P 500
This Quarter Est. Return
+45.46%
1 Year Est. Return
+203.3%
3 Year Est. Return
–
5 Year Est. Return
–
10 Year Est. Return
–
AUM
$2.56B
AUM Growth
+$624M
Cap. Flow
+$9.78M
Cap. Flow %
0.38%
Top 10 Hldgs %
47.45%
Holding
133
New
23
Increased
24
Reduced
15
Closed
18

Top Buys

Rank Stock Value
1
RZLT icon
Rezolute
RZLT
+$32.4M
2
GPCR icon
Structure Therapeutics
GPCR
+$20.5M
3
RELY icon
Remitly
RELY
+$19.8M
4
TNGX icon
Tango Therapeutics
TNGX
+$17M
5
RCUS icon
Arcus Biosciences
RCUS
+$13.5M

Top Sells

Rank Stock Value
1
MRUS
Merus
MRUS
+$44.9M
2
APGE icon
Apogee Therapeutics
APGE
+$25.8M
3
MLTX icon
MoonLake Immunotherapeutics
MLTX
+$24M
4
AKRO
Akero Therapeutics
AKRO
+$17M
5
IRON icon
Disc Medicine
IRON
+$11.1M

Sector Composition

Rank Sector Weight
1 Healthcare 91.03%
2 Technology 5.1%
3 Communication Services 1.94%
4 Consumer Discretionary 0.86%
5 Real Estate 0.74%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
PCVX icon
126
Vaxcyte
PCVX
$8.64B
– –
-295,543
Closed -$9.61M
RCKT icon
127
Rocket Pharmaceuticals
RCKT
$394M
– –
-591,263
Closed -$1.45M
TEAM icon
128
Atlassian
TEAM
$37.8B
– –
-3,500
Closed -$711K
TRML
129
DELISTED
Tourmaline Bio
TRML
– –
-91,426
Closed -$1.46M
UNH icon
130
UnitedHealth
UNH
$370B
– –
-5,076
Closed -$1.58M
VERA icon
131
Vera Therapeutics
VERA
$2.36B
– –
-247,216
Closed -$5.82M
VIGL
132
DELISTED
Vigil Neuroscience
VIGL
– –
-411,191
Closed -$3.27M
RDDT icon
133
Reddit
RDDT
$31.1B
– –
-2,000
Closed -$301K
2 3 4 5
6

Similar funds

SCM
Saba Capital Management New York $3.62B AUM 12.96% 1-Year Est. Return
ACM
Advent Capital Management New York $3.63B AUM 0.29% 1-Year Est. Return
GCM
Ghisallo Capital Management Boston, Massachusetts $3.63B AUM 30.51% 1-Year Est. Return
VI
Vestcor Inc Fredericton, New Brunswick, Canada $3.63B AUM 21.49% 1-Year Est. Return
BPS
BNDES Participacoes SA Rio De Janeiro, Brazil $3.58B AUM
VPC
Vestal Point Capital New York $3.58B AUM 189.12% 1-Year Est. Return
WWA
WCG Wealth Advisors Las Vegas, Nevada $3.57B AUM 18.63% 1-Year Est. Return
OCM
One Capital Management Westlake Village, California $3.65B AUM 15.32% 1-Year Est. Return

Siren LLC's Q3 2025 Portfolio in Review

As of Q3 2025, Siren LLC held 133 positions worth $2.56B, up 32% from $1.93B the previous quarter. Its ten largest holdings account for 47% of the portfolio.

Siren LLC's Q3 2025 filing shows 23 new, 24 increased, 15 reduced and 18 closed positions. Its largest new stake was Rezolute: 4,870,000 shares worth $45.8M. The largest sale was Merus, an estimated $44.9M.

By sector, the portfolio is most concentrated in Healthcare at 91% of assets, up from 90% a quarter earlier, followed by Technology and Communication Services.

  • Siren LLC's largest Q3 2025 buy was Rezolute: 4,870,000 shares worth $45.8M.
  • Siren LLC added most to Remitly in Q3 2025, an estimated $19.8M increase.
  • Siren LLC's biggest Q3 2025 reduction was Disc Medicine, cutting an estimated $11.1M.
  • Siren LLC fully exited Merus in Q3 2025, selling an estimated $44.9M.
  • Siren LLC's ten largest holdings make up 47% of its $2.56B portfolio in Q3 2025.
  • Siren LLC opened 23 new positions and closed 18 in Q3 2025.
  • Siren LLC's portfolio value rose 32% quarter-over-quarter to $2.56B.

Based on Siren LLC's 13F filing for Q3 2025, filed 13 Nov 2025.