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Siren LLC Portfolio holdings

AUM $3.61B
1-Year Est. Return 203.3%
This Fund
S&P 500
This Quarter Est. Return
+74.07%
1 Year Est. Return
+203.3%
3 Year Est. Return
–
5 Year Est. Return
–
10 Year Est. Return
–
AUM
$2.26B
AUM Growth
+$263M
Cap. Flow
+$190M
Cap. Flow %
8.39%
Top 10 Hldgs %
48.54%
Holding
134
New
22
Increased
21
Reduced
22
Closed
16

Top Buys

Rank Stock Value
1
SEPN
Septerna Inc
SEPN
+$52.1M
2
BCYC
Bicycle Therapeutics
BCYC
+$39.4M
3
APGE icon
Apogee Therapeutics
APGE
+$38.1M
4
MDGL icon
Madrigal Pharmaceuticals
MDGL
+$35.4M
5
NAMS icon
NewAmsterdam Pharma
NAMS
+$25M

Top Sells

Rank Stock Value
1
SRRK icon
Scholar Rock
SRRK
+$65.4M
2
LBPH
Longboard Pharmaceuticals, Inc. Common Stock
LBPH
+$30.1M
3
WVE icon
Wave Life Sciences
WVE
+$26.3M
4
ARGX icon
argenx
ARGX
+$16.8M
5
BHVN icon
Biohaven
BHVN
+$14.2M

Sector Composition

Rank Sector Weight
1 Healthcare 92.88%
2 Technology 3.51%
3 Communication Services 1.85%
4 Consumer Discretionary 0.74%
5 Real Estate 0.35%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
PYPL icon
126
CALL
PayPal
PYPL
$50.5B
– –
-26,000
Closed -$2.03M
TERN
127
DELISTED
Terns Pharmaceuticals
TERN
– –
-100,000
Closed -$834K
V icon
128
Visa
V
$677B
– –
-7,000
Closed -$1.92M
ANRO icon
129
Alto Neuroscience
ANRO
$1.11B
– –
-391,406
Closed -$4.48M
RBRK icon
130
Rubrik
RBRK
$18.5B
– –
-25,000
Closed -$804K
SYRS
131
DELISTED
Syros Pharmaceuticals, Inc. Common Stock
SYRS
– –
-2,587,372
Closed -$5.56M
PFTAW
132
CALL
DELISTED
Perception Capital Corp. III Warrant
PFTAW
– –
-126,666
Closed -$3.8K
GRTS
133
DELISTED
Gritstone bio, Inc. Common Stock
GRTS
– –
-3,318,093
Closed -$1.92M
LBPH
134
DELISTED
Longboard Pharmaceuticals, Inc. Common Stock
LBPH
– –
-903,227
Closed -$30.1M
2 3 4 5
6

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Siren LLC's Q4 2024 Portfolio in Review

As of Q4 2024, Siren LLC held 134 positions worth $2.26B, up 13% from $2B the previous quarter. Its ten largest holdings account for 49% of the portfolio.

Siren LLC deployed $190M of net new capital in Q4 2024, opening 22 new positions and adding to 21 existing holdings. Its largest new stake was Septerna Inc: 2,202,514 shares worth $50.4M.

By sector, the portfolio is most concentrated in Healthcare at 93% of assets, down from 93% a quarter earlier, followed by Technology and Communication Services.

On the sell side, the largest reduction was Scholar Rock, an estimated $65.4M trimmed.

  • Siren LLC's largest Q4 2024 buy was Septerna Inc: 2,202,514 shares worth $50.4M.
  • Siren LLC added most to NewAmsterdam Pharma in Q4 2024, an estimated $25M increase.
  • Siren LLC's biggest Q4 2024 reduction was Scholar Rock, cutting an estimated $65.4M.
  • Siren LLC fully exited Longboard Pharmaceuticals, Inc. Common Stock in Q4 2024, selling an estimated $30.1M.
  • Siren LLC's ten largest holdings make up 49% of its $2.26B portfolio in Q4 2024.
  • Siren LLC opened 22 new positions and closed 16 in Q4 2024.
  • Siren LLC's portfolio value rose 13% quarter-over-quarter to $2.26B.

Based on Siren LLC's 13F filing for Q4 2024, filed 14 Feb 2025.