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Siren LLC Portfolio holdings

AUM $3.61B
1-Year Est. Return 203.3%
This Fund
S&P 500
This Quarter Est. Return
+36.54%
1 Year Est. Return
+203.3%
3 Year Est. Return
–
5 Year Est. Return
–
10 Year Est. Return
–
AUM
$3.35B
AUM Growth
+$796M
Cap. Flow
+$176M
Cap. Flow %
5.24%
Top 10 Hldgs %
46.31%
Holding
141
New
26
Increased
29
Reduced
24
Closed
28

Top Buys

Rank Stock Value
1
SRRK icon
Scholar Rock
SRRK
+$59.1M
2
OLMA icon
Olema Pharmaceuticals
OLMA
+$58.7M
3
ZYME icon
Zymeworks
ZYME
+$36.6M
4
DBVT
DBV Technologies
DBVT
+$29M
5
MLYS icon
Mineralys Therapeutics
MLYS
+$28.1M

Top Sells

Rank Stock Value
1
ARWR icon
Arrowhead Research
ARWR
+$57.3M
2
RNAM
Avidity Biosciences
RNAM
+$56M
3
RZLT icon
Rezolute
RZLT
+$45.8M
4
SLNO
Soleno Therapeutics
SLNO
+$31.6M
5
DYN icon
Dyne Therapeutics
DYN
+$23.2M

Sector Composition

Rank Sector Weight
1 Healthcare 93.02%
2 Technology 3.72%
3 Communication Services 1.9%
4 Real Estate 0.59%
5 Consumer Discretionary 0.59%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
ARM icon
101
Arm
ARM
$277B
$2.35M 0.07%
+21,500
New +$3.13M
BEKE icon
102
KE Holdings
BEKE
$17.2B
$2.29M 0.07%
145,000
– –
TIL icon
103
Instil Bio
TIL
$48.2M
$2.24M 0.07%
203,933
– –
PANW icon
104
Palo Alto Networks
PANW
$260B
$2.11M 0.06%
11,450
-2,000
-15% -$403K
CRWV
105
CoreWeave
CRWV
$38.3B
$1.97M 0.06%
27,500
+3,500
+15% +$355K
IREN icon
106
Iris Energy
IREN
$12.8B
$1.63M 0.05%
43,100
+23,100
+116% +$1.19M
VRNS icon
107
Varonis Systems
VRNS
$5.35B
$1.23M 0.04%
+37,500
New +$1.57M
PRMB
108
Primo Brands
PRMB
$8.32B
$1.23M 0.04%
75,000
– –
GBIO
109
DELISTED
Generation Bio
GBIO
$1.14M 0.03%
201,419
-95,473
-32% -$539K
FIG
110
Figma
FIG
$12B
$934K 0.03%
25,000
+10,000
+67% +$452K
TSLA icon
111
Tesla
TSLA
$1.22T
$675K 0.02%
1,500
– –
CRBU icon
112
Caribou Biosciences
CRBU
$160M
$168K 0.01%
105,347
– –
CYCN icon
113
Cyclerion Therapeutics
CYCN
$15.1M
$147K ﹤0.01%
115,603
-552
-0.5% -$985
CCC
114
CCC Intelligent Solutions
CCC
$3.56B
– –
-50,000
Closed -$456K
CFLT
115
DELISTED
Confluent
CFLT
– –
-37,500
Closed -$743K
CMG icon
116
Chipotle Mexican Grill
CMG
$42.5B
– –
-47,500
Closed -$1.86M
ELDN icon
117
Eledon Pharmaceuticals
ELDN
$275M
– –
-2,072,767
Closed -$5.37M
ESTC icon
118
Elastic
ESTC
$6.45B
– –
-12,500
Closed -$1.06M
HUBS icon
119
HubSpot
HUBS
$11.7B
– –
-4,000
Closed -$1.87M
IRWD icon
120
Ironwood Pharmaceuticals
IRWD
$645M
– –
-110,532
Closed -$145K
KDP icon
121
Keurig Dr Pepper
KDP
$41B
– –
-77,050
Closed -$1.97M
KVUE icon
122
Kenvue
KVUE
$37.3B
– –
-25,000
Closed -$406K
NAMS icon
123
NewAmsterdam Pharma
NAMS
$3.54B
– –
-765,705
Closed -$21.8M
PCOR icon
124
Procore
PCOR
$7.05B
– –
-10,000
Closed -$729K
PINS icon
125
Pinterest
PINS
$13.2B
– –
-25,000
Closed -$804K
2 3 4
5
6

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Siren LLC's Q4 2025 Portfolio in Review

As of Q4 2025, Siren LLC held 141 positions worth $3.35B, up 31% from $2.56B the previous quarter. Its ten largest holdings account for 46% of the portfolio.

Siren LLC deployed $176M of net new capital in Q4 2025, opening 26 new positions and adding to 29 existing holdings. Its largest new stake was Olema Pharmaceuticals: 3,300,700 shares worth $82.5M.

By sector, the portfolio is most concentrated in Healthcare at 93% of assets, up from 91% a quarter earlier, followed by Technology and Communication Services.

On the sell side, the largest reduction was Arrowhead Research, an estimated $57.3M trimmed.

  • Siren LLC's largest Q4 2025 buy was Olema Pharmaceuticals: 3,300,700 shares worth $82.5M.
  • Siren LLC added most to Scholar Rock in Q4 2025, an estimated $59.1M increase.
  • Siren LLC's biggest Q4 2025 reduction was Arrowhead Research, cutting an estimated $57.3M.
  • Siren LLC fully exited Avidity Biosciences in Q4 2025, selling an estimated $56M.
  • Siren LLC's ten largest holdings make up 46% of its $3.35B portfolio in Q4 2025.
  • Siren LLC opened 26 new positions and closed 28 in Q4 2025.
  • Siren LLC's portfolio value rose 31% quarter-over-quarter to $3.35B.

Based on Siren LLC's 13F filing for Q4 2025, filed 13 Feb 2026.