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Siren LLC Portfolio holdings
AUM
$4.94B
1-Year Est. Return
244.43%
This Fund
S&P 500
This Quarter
Est. Return
+36.54%
1 Year Est. Return
+244.43%
3 Year Est. Return
–
5 Year Est. Return
–
10 Year Est. Return
–
AUM
$3.35B
AUM Growth
+$796M
(+31%)
Cap. Flow
+$176M
Cap. Flow
% of AUM
5.24%
Top 10 Holdings %
Top 10 Hldgs %
46.31%
Holding
141
New
26
Increased
29
Reduced
24
Closed
28
Top Buys
| Rank | Stock | Value |
|---|---|---|
| 1 |
Scholar Rock
SRRK
|
+$59.1M |
| 2 |
Olema Pharmaceuticals
OLMA
|
+$58.7M |
| 3 |
Zymeworks
ZYME
|
+$36.6M |
| 4 |
DBVT
DBV Technologies
DBVT
|
+$29M |
| 5 |
Mineralys Therapeutics
MLYS
|
+$28.1M |
Top Sells
| Rank | Stock | Value |
|---|---|---|
| 1 |
Arrowhead Research
ARWR
|
+$57.3M |
| 2 |
RNAM
Avidity Biosciences
RNAM
|
+$56M |
| 3 |
Rezolute
RZLT
|
+$45.8M |
| 4 |
SLNO
Soleno Therapeutics
SLNO
|
+$31.6M |
| 5 |
Dyne Therapeutics
DYN
|
+$23.2M |
Sector Composition
| Rank | Sector | Weight |
|---|---|---|
| 1 | Healthcare | 93.02% |
| 2 | Technology | 3.72% |
| 3 | Communication Services | 1.9% |
| 4 | Real Estate | 0.59% |
| 5 | Consumer Discretionary | 0.59% |
| Name | Market Value | Portfolio Weight | Shares or Principal |
Change in Stake | Capital Flow | |
|---|---|---|---|---|---|---|
101
Arm
ARM
$283B
| $2.35M | 0.07% |
+21,500
| New | +$3.13M |
|
102
KE Holdings
BEKE
$17.6B
| $2.29M | 0.07% |
145,000
| – | – |
|
103
Instil Bio
TIL
$48.9M
| $2.24M | 0.07% |
203,933
| – | – |
|
104
Palo Alto Networks
PANW
$307B
| $2.11M | 0.06% |
11,450
-2,000
| -15% | -$403K |
|
|
CRWV
105
CoreWeave
CRWV
$44.1B
| $1.97M | 0.06% |
27,500
+3,500
| +15% | +$355K |
|
106
Iris Energy
IREN
$17.1B
| $1.63M | 0.05% |
43,100
+23,100
| +116% | +$1.19M |
|
107
Varonis Systems
VRNS
$5.49B
| $1.23M | 0.04% |
+37,500
| New | +$1.57M |
|
|
PRMB
108
Primo Brands
PRMB
$7.64B
| $1.23M | 0.04% |
75,000
| – | – |
|
|
GBIO
109
DELISTED
Generation Bio
GBIO
| $1.14M | 0.03% |
201,419
-95,473
| -32% | -$539K |
|
|
FIG
110
Figma
FIG
$12.4B
| $934K | 0.03% |
25,000
+10,000
| +67% | +$452K |
|
111
Tesla
TSLA
$1.45T
| $675K | 0.02% |
1,500
| – | – |
|
112
Caribou Biosciences
CRBU
$140M
| $168K | 0.01% |
105,347
| – | – |
|
|
CYCN
113
DELISTED
Cyclerion Therapeutics
CYCN
| $147K | ﹤0.01% |
115,603
-552
| -0.5% | -$985 |
|
|
CCC
114
CCC Intelligent Solutions
CCC
$3.89B
| – | – |
-50,000
| Closed | -$456K |
|
|
CFLT
115
DELISTED
Confluent
CFLT
| – | – |
-37,500
| Closed | -$743K |
|
116
Chipotle Mexican Grill
CMG
$42.4B
| – | – |
-47,500
| Closed | -$1.86M |
|
117
Eledon Pharmaceuticals
ELDN
$215M
| – | – |
-2,072,767
| Closed | -$5.37M |
|
118
Elastic
ESTC
$9.34B
| – | – |
-12,500
| Closed | -$1.06M |
|
119
HubSpot
HUBS
$11.4B
| – | – |
-4,000
| Closed | -$1.87M |
|
120
Ironwood Pharmaceuticals
IRWD
$699M
| – | – |
-110,532
| Closed | -$145K |
|
121
Keurig Dr Pepper
KDP
$42.8B
| – | – |
-77,050
| Closed | -$1.97M |
|
122
Kenvue
KVUE
$34.3B
| – | – |
-25,000
| Closed | -$406K |
|
123
NewAmsterdam Pharma
NAMS
$2.62B
| – | – |
-765,705
| Closed | -$21.8M |
|
124
Procore
PCOR
$7.86B
| – | – |
-10,000
| Closed | -$729K |
|
125
Pinterest
PINS
$10.4B
| – | – |
-25,000
| Closed | -$804K |
|
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Siren LLC's Q4 2025 Portfolio in Review
As of Q4 2025, Siren LLC held 141 positions worth $3.35B, up 31% from $2.56B the previous quarter. Its ten largest holdings account for 46% of the portfolio.
Siren LLC deployed $176M of net new capital in Q4 2025, opening 26 new positions and adding to 29 existing holdings. Its largest new stake was Olema Pharmaceuticals: 3,300,700 shares worth $82.5M.
By sector, the portfolio is most concentrated in Healthcare at 93% of assets, up from 91% a quarter earlier, followed by Technology and Communication Services.
On the sell side, the largest reduction was Arrowhead Research, an estimated $57.3M trimmed.
- Siren LLC's largest Q4 2025 buy was Olema Pharmaceuticals: 3,300,700 shares worth $82.5M.
- Siren LLC added most to Scholar Rock in Q4 2025, an estimated $59.1M increase.
- Siren LLC's biggest Q4 2025 reduction was Arrowhead Research, cutting an estimated $57.3M.
- Siren LLC fully exited Avidity Biosciences in Q4 2025, selling an estimated $56M.
- Siren LLC's ten largest holdings make up 46% of its $3.35B portfolio in Q4 2025.
- Siren LLC opened 26 new positions and closed 28 in Q4 2025.
- Siren LLC's portfolio value rose 31% quarter-over-quarter to $3.35B.
Based on Siren LLC's 13F filing for Q4 2025, filed 13 Feb 2026.