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Siren LLC Portfolio holdings

AUM $3.61B
1-Year Est. Return 203.3%
This Fund
S&P 500
This Quarter Est. Return
+45.46%
1 Year Est. Return
+203.3%
3 Year Est. Return
–
5 Year Est. Return
–
10 Year Est. Return
–
AUM
$2.56B
AUM Growth
+$624M
Cap. Flow
+$9.78M
Cap. Flow %
0.38%
Top 10 Hldgs %
47.45%
Holding
133
New
23
Increased
24
Reduced
15
Closed
18

Top Buys

Rank Stock Value
1
RZLT icon
Rezolute
RZLT
+$32.4M
2
GPCR icon
Structure Therapeutics
GPCR
+$20.5M
3
RELY icon
Remitly
RELY
+$19.8M
4
TNGX icon
Tango Therapeutics
TNGX
+$17M
5
RCUS icon
Arcus Biosciences
RCUS
+$13.5M

Top Sells

Rank Stock Value
1
MRUS
Merus
MRUS
+$44.9M
2
APGE icon
Apogee Therapeutics
APGE
+$25.8M
3
MLTX icon
MoonLake Immunotherapeutics
MLTX
+$24M
4
AKRO
Akero Therapeutics
AKRO
+$17M
5
IRON icon
Disc Medicine
IRON
+$11.1M

Sector Composition

Rank Sector Weight
1 Healthcare 91.03%
2 Technology 5.1%
3 Communication Services 1.94%
4 Consumer Discretionary 0.86%
5 Real Estate 0.74%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
SEMR
101
DELISTED
Semrush
SEMR
$885K 0.03%
125,000
– –
AS icon
102
Amer Sports
AS
$21.4B
$869K 0.03%
+25,000
New +$943K
PINS icon
103
Pinterest
PINS
$13.4B
$804K 0.03%
+25,000
New +$907K
FIG
104
Figma
FIG
$12.4B
$778K 0.03%
+15,000
New +$1.03M
CFLT
105
DELISTED
Confluent
CFLT
$743K 0.03%
+37,500
New +$784K
PCOR icon
106
Procore
PCOR
$8.67B
$729K 0.03%
10,000
– –
ALAB icon
107
Astera Labs
ALAB
$58B
$685K 0.03%
+3,500
New +$576K
TSLA icon
108
Tesla
TSLA
$1.3T
$667K 0.03%
1,500
-2,500
-63% -$867K
CHYM
109
Chime Financial
CHYM
$11B
$504K 0.02%
+25,000
New +$710K
CCC
110
CCC Intelligent Solutions
CCC
$4.08B
$456K 0.02%
50,000
– –
KVUE icon
111
Kenvue
KVUE
$36.9B
$406K 0.02%
+25,000
New +$510K
VRT icon
112
Vertiv
VRT
$105B
$302K 0.01%
2,000
– –
CYCN icon
113
Cyclerion Therapeutics
CYCN
$16.7M
$267K 0.01%
116,155
– –
CRBU icon
114
Caribou Biosciences
CRBU
$164M
$245K 0.01%
105,347
– –
IRWD icon
115
Ironwood Pharmaceuticals
IRWD
$714M
$145K 0.01%
110,532
– –
AKRO
116
DELISTED
Akero Therapeutics
AKRO
– –
-318,647
Closed -$17M
APGE icon
117
Apogee Therapeutics
APGE
$10.2B
– –
-594,994
Closed -$25.8M
BIRK icon
118
Birkenstock
BIRK
$7.07B
– –
-25,000
Closed -$1.23M
DECK icon
119
Deckers Outdoor
DECK
$13.3B
– –
-2,000
Closed -$206K
HOOK
120
DELISTED
HOOKIPA Pharma
HOOK
– –
-566,640
Closed -$711K
IGMS
121
DELISTED
IGM Biosciences
IGMS
– –
-3,255,826
Closed -$3.65M
MLTX icon
122
MoonLake Immunotherapeutics
MLTX
$1.55B
– –
-508,267
Closed -$24M
MRUS
123
DELISTED
Merus
MRUS
– –
-853,467
Closed -$44.9M
PCG icon
124
PG&E
PCG
$38.5B
– –
-25,000
Closed -$349K
PCRX icon
125
Pacira BioSciences
PCRX
$997M
– –
-225,000
Closed -$5.38M
2 3 4
5
6

Similar funds

SCM
Saba Capital Management New York $3.62B AUM 12.96% 1-Year Est. Return
ACM
Advent Capital Management New York $3.63B AUM 0.29% 1-Year Est. Return
GCM
Ghisallo Capital Management Boston, Massachusetts $3.63B AUM 30.51% 1-Year Est. Return
VI
Vestcor Inc Fredericton, New Brunswick, Canada $3.63B AUM 21.49% 1-Year Est. Return
BPS
BNDES Participacoes SA Rio De Janeiro, Brazil $3.58B AUM
VPC
Vestal Point Capital New York $3.58B AUM 189.12% 1-Year Est. Return
WWA
WCG Wealth Advisors Las Vegas, Nevada $3.57B AUM 18.63% 1-Year Est. Return
OCM
One Capital Management Westlake Village, California $3.65B AUM 15.32% 1-Year Est. Return

Siren LLC's Q3 2025 Portfolio in Review

As of Q3 2025, Siren LLC held 133 positions worth $2.56B, up 32% from $1.93B the previous quarter. Its ten largest holdings account for 47% of the portfolio.

Siren LLC's Q3 2025 filing shows 23 new, 24 increased, 15 reduced and 18 closed positions. Its largest new stake was Rezolute: 4,870,000 shares worth $45.8M. The largest sale was Merus, an estimated $44.9M.

By sector, the portfolio is most concentrated in Healthcare at 91% of assets, up from 90% a quarter earlier, followed by Technology and Communication Services.

  • Siren LLC's largest Q3 2025 buy was Rezolute: 4,870,000 shares worth $45.8M.
  • Siren LLC added most to Remitly in Q3 2025, an estimated $19.8M increase.
  • Siren LLC's biggest Q3 2025 reduction was Disc Medicine, cutting an estimated $11.1M.
  • Siren LLC fully exited Merus in Q3 2025, selling an estimated $44.9M.
  • Siren LLC's ten largest holdings make up 47% of its $2.56B portfolio in Q3 2025.
  • Siren LLC opened 23 new positions and closed 18 in Q3 2025.
  • Siren LLC's portfolio value rose 32% quarter-over-quarter to $2.56B.

Based on Siren LLC's 13F filing for Q3 2025, filed 13 Nov 2025.