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Siren LLC Portfolio holdings

AUM $3.61B
1-Year Est. Return 203.3%
This Fund
S&P 500
This Quarter Est. Return
+36.54%
1 Year Est. Return
+203.3%
3 Year Est. Return
–
5 Year Est. Return
–
10 Year Est. Return
–
AUM
$3.35B
AUM Growth
+$796M
Cap. Flow
+$176M
Cap. Flow %
5.24%
Top 10 Hldgs %
46.31%
Holding
141
New
26
Increased
29
Reduced
24
Closed
28

Top Buys

Rank Stock Value
1
SRRK icon
Scholar Rock
SRRK
+$59.1M
2
OLMA icon
Olema Pharmaceuticals
OLMA
+$58.7M
3
ZYME icon
Zymeworks
ZYME
+$36.6M
4
DBVT
DBV Technologies
DBVT
+$29M
5
MLYS icon
Mineralys Therapeutics
MLYS
+$28.1M

Top Sells

Rank Stock Value
1
ARWR icon
Arrowhead Research
ARWR
+$57.3M
2
RNAM
Avidity Biosciences
RNAM
+$56M
3
RZLT icon
Rezolute
RZLT
+$45.8M
4
SLNO
Soleno Therapeutics
SLNO
+$31.6M
5
DYN icon
Dyne Therapeutics
DYN
+$23.2M

Sector Composition

Rank Sector Weight
1 Healthcare 93.02%
2 Technology 3.72%
3 Communication Services 1.9%
4 Real Estate 0.59%
5 Consumer Discretionary 0.59%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
FROG icon
76
JFrog
FROG
$9.88B
$5.85M 0.17%
93,616
-13,500
-13% -$768K
NOW icon
77
ServiceNow
NOW
$111B
$5.46M 0.16%
35,630
– –
TENX icon
78
Tenax Therapeutics
TENX
$412M
$5.21M 0.16%
427,141
+74,700
+21% +$650K
WHWK
79
Whitehawk Therapeutics
WHWK
$184M
$5.04M 0.15%
2,082,000
– –
DT icon
80
Dynatrace
DT
$12.7B
$4.99M 0.15%
115,229
+15,000
+15% +$699K
DDOG icon
81
Datadog
DDOG
$90.9B
$4.95M 0.15%
36,425
+3,500
+11% +$553K
ALMS
82
Alumis Inc
ALMS
$3.43B
$4.88M 0.15%
+500,000
New +$3.49M
META icon
83
Meta Platforms (Facebook)
META
$1.51T
$4.73M 0.14%
+7,169
New +$4.79M
PEPG icon
84
PepGen
PEPG
$132M
$4.56M 0.14%
700,000
– –
SGMT icon
85
Sagimet Biosciences
SGMT
$462M
$4.29M 0.13%
724,771
– –
ADBE icon
86
Adobe
ADBE
$96B
$4.22M 0.13%
12,051
-3,000
-20% -$1.02M
FHTX icon
87
Foghorn Therapeutics
FHTX
$299M
$3.89M 0.12%
720,720
– –
GTLB icon
88
GitLab
GTLB
$5.66B
$3.72M 0.11%
99,000
+35,000
+55% +$1.52M
KLRS
89
Kalaris Therapeutics
KLRS
$85.7M
$3.68M 0.11%
435,798
+117,534
+37% +$752K
EDU icon
90
New Oriental
EDU
$7.92B
$3.41M 0.1%
62,000
– –
AGEN
91
Agenus
AGEN
$257M
$3.34M 0.1%
1,064,250
– –
MDLN
92
Medline Inc
MDLN
$34B
$3.15M 0.09%
+75,000
New +$3.17M
KRRO icon
93
Korro Bio
KRRO
$151M
$2.79M 0.08%
347,718
-71,115
-17% -$1.66M
CLBT icon
94
Cellebrite
CLBT
$3.7B
$2.71M 0.08%
150,000
+60,000
+67% +$1.08M
RANI icon
95
Rani Therapeutics
RANI
$89.9M
$2.7M 0.08%
+2,000,000
New +$3.02M
ZS icon
96
Zscaler
ZS
$23.9B
$2.7M 0.08%
+12,000
New +$3.39M
BDTX icon
97
Black Diamond Therapeutics
BDTX
$101M
$2.54M 0.08%
1,046,517
– –
MNDY icon
98
monday.com
MNDY
$3.51B
$2.51M 0.07%
17,000
+10,000
+143% +$1.68M
AVGO icon
99
Broadcom
AVGO
$1.81T
$2.42M 0.07%
+7,000
New +$2.5M
QCOM icon
100
Qualcomm
QCOM
$177B
$2.39M 0.07%
14,000
– –
2 3
4
5 6

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Siren LLC's Q4 2025 Portfolio in Review

As of Q4 2025, Siren LLC held 141 positions worth $3.35B, up 31% from $2.56B the previous quarter. Its ten largest holdings account for 46% of the portfolio.

Siren LLC deployed $176M of net new capital in Q4 2025, opening 26 new positions and adding to 29 existing holdings. Its largest new stake was Olema Pharmaceuticals: 3,300,700 shares worth $82.5M.

By sector, the portfolio is most concentrated in Healthcare at 93% of assets, up from 91% a quarter earlier, followed by Technology and Communication Services.

On the sell side, the largest reduction was Arrowhead Research, an estimated $57.3M trimmed.

  • Siren LLC's largest Q4 2025 buy was Olema Pharmaceuticals: 3,300,700 shares worth $82.5M.
  • Siren LLC added most to Scholar Rock in Q4 2025, an estimated $59.1M increase.
  • Siren LLC's biggest Q4 2025 reduction was Arrowhead Research, cutting an estimated $57.3M.
  • Siren LLC fully exited Avidity Biosciences in Q4 2025, selling an estimated $56M.
  • Siren LLC's ten largest holdings make up 46% of its $3.35B portfolio in Q4 2025.
  • Siren LLC opened 26 new positions and closed 28 in Q4 2025.
  • Siren LLC's portfolio value rose 31% quarter-over-quarter to $3.35B.

Based on Siren LLC's 13F filing for Q4 2025, filed 13 Feb 2026.