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Siren LLC Portfolio holdings

AUM $3.61B
1-Year Est. Return 203.3%
This Fund
S&P 500
This Quarter Est. Return
+36.54%
1 Year Est. Return
+203.3%
3 Year Est. Return
–
5 Year Est. Return
–
10 Year Est. Return
–
AUM
$3.35B
AUM Growth
+$796M
Cap. Flow
+$176M
Cap. Flow %
5.24%
Top 10 Hldgs %
46.31%
Holding
141
New
26
Increased
29
Reduced
24
Closed
28

Top Buys

Rank Stock Value
1
SRRK icon
Scholar Rock
SRRK
+$59.1M
2
OLMA icon
Olema Pharmaceuticals
OLMA
+$58.7M
3
ZYME icon
Zymeworks
ZYME
+$36.6M
4
DBVT
DBV Technologies
DBVT
+$29M
5
MLYS icon
Mineralys Therapeutics
MLYS
+$28.1M

Top Sells

Rank Stock Value
1
ARWR icon
Arrowhead Research
ARWR
+$57.3M
2
RNAM
Avidity Biosciences
RNAM
+$56M
3
RZLT icon
Rezolute
RZLT
+$45.8M
4
SLNO
Soleno Therapeutics
SLNO
+$31.6M
5
DYN icon
Dyne Therapeutics
DYN
+$23.2M

Sector Composition

Rank Sector Weight
1 Healthcare 93.02%
2 Technology 3.72%
3 Communication Services 1.9%
4 Real Estate 0.59%
5 Consumer Discretionary 0.59%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
NMRA icon
51
Neumora Therapeutics
NMRA
$308M
$11.3M 0.34%
6,288,783
+1,930,500
+44% +$4.23M
DFTX
52
Definium Therapeutics
DFTX
$5.66B
$10.7M 0.32%
+800,000
New +$9.9M
BNTC icon
53
Benitec Biopharma
BNTC
$398M
$10.4M 0.31%
+775,000
New +$10.7M
IVVD icon
54
Invivyd
IVVD
$180M
$9.88M 0.29%
+4,000,000
New +$8.32M
TSM icon
55
TSMC
TSM
$2.07T
$8.42M 0.25%
27,700
-500
-2% -$147K
ORIC icon
56
Oric Pharmaceuticals
ORIC
$1.24B
$8.24M 0.25%
1,007,575
– –
MPLT
57
MapLight Therapeutics
MPLT
$449M
$7.9M 0.24%
+450,000
New +$7.54M
PVLA
58
Palvella Therapeutics
PVLA
$2.03B
$7.85M 0.23%
+75,000
New +$6.4M
CRWD icon
59
CrowdStrike
CRWD
$183B
$7.73M 0.23%
66,000
-8,000
-11% -$1.02M
IONQ icon
60
IonQ
IONQ
$13.4B
$7.63M 0.23%
170,000
– –
SEER icon
61
Seer Inc
SEER
$108M
$7.32M 0.22%
4,000,000
– –
MSFT icon
62
Microsoft
MSFT
$2.89T
$7.25M 0.22%
15,000
-2,150
-13% -$1.08M
PDD icon
63
Pinduoduo
PDD
$121B
$7.19M 0.21%
63,401
+20,000
+46% +$2.48M
LXEO icon
64
Lexeo Therapeutics
LXEO
$351M
$7.16M 0.21%
720,622
+117,187
+19% +$1.07M
NVDA icon
65
NVIDIA
NVDA
$4.76T
$6.99M 0.21%
37,485
– –
CRM icon
66
Salesforce
CRM
$142B
$6.91M 0.21%
26,100
-4,000
-13% -$994K
CMPS
67
Compass Pathways
CMPS
$1.52B
$6.9M 0.21%
+1,000,000
New +$6.1M
BLLN
68
BillionToOne Inc
BLLN
$5.89B
$6.86M 0.2%
+83,833
New +$8.5M
WK icon
69
Workiva
WK
$3.13B
$6.82M 0.2%
79,123
+49,123
+164% +$4.35M
ZURA icon
70
Zura Bio
ZURA
$511M
$6.81M 0.2%
+1,300,000
New +$5.14M
VTVT icon
71
vTv Therapeutics
VTVT
$122M
$6.52M 0.19%
163,000
– –
GOOGL icon
72
Alphabet (Google) Class A
GOOGL
$3.99T
$6.48M 0.19%
20,703
-500
-2% -$143K
NBIS
73
Nebius Group N.V.
NBIS
$47.7B
$6.38M 0.19%
76,218
+3,618
+5% +$375K
SVRA icon
74
Savara
SVRA
$1.11B
$6.03M 0.18%
+1,000,000
New +$4.9M
XFOR icon
75
X4 Pharmaceuticals
XFOR
$372M
$6M 0.18%
+1,500,000
New +$5.45M
1 2
3
4 5

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Siren LLC's Q4 2025 Portfolio in Review

As of Q4 2025, Siren LLC held 141 positions worth $3.35B, up 31% from $2.56B the previous quarter. Its ten largest holdings account for 46% of the portfolio.

Siren LLC deployed $176M of net new capital in Q4 2025, opening 26 new positions and adding to 29 existing holdings. Its largest new stake was Olema Pharmaceuticals: 3,300,700 shares worth $82.5M.

By sector, the portfolio is most concentrated in Healthcare at 93% of assets, up from 91% a quarter earlier, followed by Technology and Communication Services.

On the sell side, the largest reduction was Arrowhead Research, an estimated $57.3M trimmed.

  • Siren LLC's largest Q4 2025 buy was Olema Pharmaceuticals: 3,300,700 shares worth $82.5M.
  • Siren LLC added most to Scholar Rock in Q4 2025, an estimated $59.1M increase.
  • Siren LLC's biggest Q4 2025 reduction was Arrowhead Research, cutting an estimated $57.3M.
  • Siren LLC fully exited Avidity Biosciences in Q4 2025, selling an estimated $56M.
  • Siren LLC's ten largest holdings make up 46% of its $3.35B portfolio in Q4 2025.
  • Siren LLC opened 26 new positions and closed 28 in Q4 2025.
  • Siren LLC's portfolio value rose 31% quarter-over-quarter to $3.35B.

Based on Siren LLC's 13F filing for Q4 2025, filed 13 Feb 2026.