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SL

Siren LLC Portfolio holdings

AUM $3.61B
1-Year Est. Return 203.3%
This Fund
S&P 500
This Quarter Est. Return
-13.7%
1 Year Est. Return
+203.3%
3 Year Est. Return
–
5 Year Est. Return
–
10 Year Est. Return
–
AUM
$1.77B
AUM Growth
-$491M
Cap. Flow
+$34.8M
Cap. Flow %
1.96%
Top 10 Hldgs %
50.37%
Holding
141
New
23
Increased
28
Reduced
41
Closed
25

Top Buys

Rank Stock Value
1
BPMC
Blueprint Medicines
BPMC
+$70.8M
2
IRON icon
Disc Medicine
IRON
+$59.6M
3
EWTX icon
Edgewise Therapeutics
EWTX
+$25.2M
4
DYN icon
Dyne Therapeutics
DYN
+$19.6M
5
SLNO
Soleno Therapeutics
SLNO
+$18.3M

Top Sells

Rank Stock Value
1
ARGX icon
argenx
ARGX
+$70.8M
2
SWTX
SpringWorks Therapeutics
SWTX
+$49.8M
3
MDGL icon
Madrigal Pharmaceuticals
MDGL
+$38.9M
4
ONC
BeOne Medicines Ltd
ONC
+$36.2M
5
CYTK icon
Cytokinetics
CYTK
+$18.9M

Sector Composition

Rank Sector Weight
1 Healthcare 89.75%
2 Technology 5.2%
3 Communication Services 2.41%
4 Consumer Discretionary 1.21%
5 Real Estate 0.81%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
PDD icon
51
Pinduoduo
PDD
$131B
$6.26M 0.35%
52,901
– –
SYRE icon
52
Spyre Therapeutics
SYRE
$9.25B
$5.95M 0.34%
368,598
-5,402
-1% -$112K
GOSS icon
53
Gossamer Bio
GOSS
$87M
$5.73M 0.32%
5,208,968
– –
ORIC icon
54
Oric Pharmaceuticals
ORIC
$1.4B
$5.62M 0.32%
1,007,575
– –
UPB
55
Upstream Bio Inc
UPB
$395M
$4.83M 0.27%
788,450
-11,550
-1% -$110K
NVDA icon
56
NVIDIA
NVDA
$5.42T
$4.82M 0.27%
44,432
-4,500
-9% -$570K
TSM icon
57
TSMC
TSM
$2.18T
$4.73M 0.27%
28,500
+13,500
+90% +$2.62M
DDOG icon
58
Datadog
DDOG
$84B
$4.71M 0.27%
47,425
+17,000
+56% +$2.15M
NMRA icon
59
Neumora Therapeutics
NMRA
$302M
$4.36M 0.25%
4,358,283
-37,817
-0.9% -$64.8K
FROG icon
60
JFrog
FROG
$10.8B
$4.21M 0.24%
131,616
+11,500
+10% +$400K
DT icon
61
Dynatrace
DT
$14.2B
$4.14M 0.23%
87,729
+5,000
+6% +$274K
MTSR
62
DELISTED
Metsera Inc
MTSR
$4.08M 0.23%
+150,000
New +$4.25M
RCKT icon
63
Rocket Pharmaceuticals
RCKT
$394M
$3.94M 0.22%
591,263
-8,737
-1% -$86.3K
CRM icon
64
Salesforce
CRM
$158B
$3.92M 0.22%
+14,600
New +$4.54M
EDU icon
65
New Oriental
EDU
$8.98B
$3.8M 0.21%
79,500
+11,000
+16% +$565K
RAPP
66
Rapport Therapeutics
RAPP
$2.18B
$3.8M 0.21%
378,469
-5,728
-1% -$74.4K
IONQ icon
67
IonQ
IONQ
$16.6B
$3.75M 0.21%
170,000
– –
IGMS
68
DELISTED
IGM Biosciences
IGMS
$3.74M 0.21%
3,255,826
-74,596
-2% -$139K
WHWK
69
Whitehawk Therapeutics
WHWK
$271M
$3.71M 0.21%
+2,082,000
New +$5.44M
TIL icon
70
Instil Bio
TIL
$50.3M
$3.54M 0.2%
203,933
+11,500
+6% +$239K
TNGX icon
71
Tango Therapeutics
TNGX
$4.41B
$3.51M 0.2%
2,565,342
-38,555
-1% -$94.7K
VIGL
72
DELISTED
Vigil Neuroscience
VIGL
$3.5M 0.2%
1,967,064
-23,974
-1% -$53.8K
SION
73
Sionna Therapeutics
SION
$2.31B
$3.4M 0.19%
+325,000
New +$5.31M
NBIS
74
Nebius Group N.V.
NBIS
$47.7B
$2.96M 0.17%
140,000
+20,000
+17% +$658K
FHTX icon
75
Foghorn Therapeutics
FHTX
$360M
$2.63M 0.15%
720,720
– –
1 2
3
4 5

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GCM
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VI
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BPS
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VPC
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WWA
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OCM
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Siren LLC's Q1 2025 Portfolio in Review

As of Q1 2025, Siren LLC held 141 positions worth $1.77B, down 22% from $2.26B the previous quarter. Its ten largest holdings account for 50% of the portfolio.

Siren LLC's Q1 2025 filing shows 23 new, 28 increased, 41 reduced and 25 closed positions. Its largest new stake was Blueprint Medicines: 726,167 shares worth $64.3M. The largest sale was argenx, an estimated $70.8M.

By sector, the portfolio is most concentrated in Healthcare at 90% of assets, down from 93% a quarter earlier, followed by Technology and Communication Services.

  • Siren LLC's largest Q1 2025 buy was Blueprint Medicines: 726,167 shares worth $64.3M.
  • Siren LLC added most to Edgewise Therapeutics in Q1 2025, an estimated $25.2M increase.
  • Siren LLC's biggest Q1 2025 reduction was BeOne Medicines Ltd, cutting an estimated $36.2M.
  • Siren LLC fully exited argenx in Q1 2025, selling an estimated $70.8M.
  • Siren LLC's ten largest holdings make up 50% of its $1.77B portfolio in Q1 2025.
  • Siren LLC opened 23 new positions and closed 25 in Q1 2025.
  • Siren LLC's portfolio value fell 22% quarter-over-quarter to $1.77B.

Based on Siren LLC's 13F filing for Q1 2025, filed 14 May 2025.