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SL

Siren LLC Portfolio holdings

AUM $3.61B
1-Year Est. Return 203.3%
This Fund
S&P 500
This Quarter Est. Return
+45.46%
1 Year Est. Return
+203.3%
3 Year Est. Return
–
5 Year Est. Return
–
10 Year Est. Return
–
AUM
$2.56B
AUM Growth
+$624M
Cap. Flow
+$9.78M
Cap. Flow %
0.38%
Top 10 Hldgs %
47.45%
Holding
133
New
23
Increased
24
Reduced
15
Closed
18

Top Buys

Rank Stock Value
1
RZLT icon
Rezolute
RZLT
+$32.4M
2
GPCR icon
Structure Therapeutics
GPCR
+$20.5M
3
RELY icon
Remitly
RELY
+$19.8M
4
TNGX icon
Tango Therapeutics
TNGX
+$17M
5
RCUS icon
Arcus Biosciences
RCUS
+$13.5M

Top Sells

Rank Stock Value
1
MRUS
Merus
MRUS
+$44.9M
2
APGE icon
Apogee Therapeutics
APGE
+$25.8M
3
MLTX icon
MoonLake Immunotherapeutics
MLTX
+$24M
4
AKRO
Akero Therapeutics
AKRO
+$17M
5
IRON icon
Disc Medicine
IRON
+$11.1M

Sector Composition

Rank Sector Weight
1 Healthcare 91.03%
2 Technology 5.1%
3 Communication Services 1.94%
4 Consumer Discretionary 0.86%
5 Real Estate 0.74%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
SLNO
26
DELISTED
Soleno Therapeutics
SLNO
$31.6M 1.24%
467,342
– –
RAPP
27
Rapport Therapeutics
RAPP
$2.18B
$31.3M 1.22%
1,053,469
+675,000
+178% +$12M
GPCR icon
28
Structure Therapeutics
GPCR
$3.78B
$28.8M 1.12%
+1,026,811
New +$20.5M
WVE icon
29
Wave Life Sciences
WVE
$1.2B
$27.1M 1.06%
3,696,322
– –
RELY icon
30
Remitly
RELY
$5.14B
$26.4M 1.03%
1,618,271
+1,102,822
+214% +$19.8M
COGT icon
31
Cogent Biosciences
COGT
$7.24B
$24.8M 0.97%
1,724,279
+869,900
+102% +$10.3M
TRVI icon
32
Trevi Therapeutics
TRVI
$2.64B
$23.2M 0.91%
2,536,867
-1,401,926
-36% -$10.5M
NAMS icon
33
NewAmsterdam Pharma
NAMS
$3.34B
$21.8M 0.85%
765,705
-428,535
-36% -$10.3M
KRRO icon
34
Korro Bio
KRRO
$195M
$20.1M 0.78%
418,833
– –
ERAS icon
35
Erasca
ERAS
$6.39B
$19.1M 0.75%
8,757,249
– –
IHS icon
36
IHS Holding
IHS
$2.81B
$16.1M 0.63%
2,357,520
– –
QURE icon
37
uniQure
QURE
$3.22B
$16.1M 0.63%
+275,200
New +$5M
BCYC
38
Bicycle Therapeutics
BCYC
$292M
$15.6M 0.61%
2,012,752
– –
SLN
39
Silence Therapeutics
SLN
$564M
$15.1M 0.59%
2,911,438
– –
RAPT
40
DELISTED
RAPT Therapeutics
RAPT
$15M 0.59%
+580,466
New +$7.6M
UPB
41
Upstream Bio Inc
UPB
$395M
$14.8M 0.58%
788,450
– –
GOSS icon
42
Gossamer Bio
GOSS
$87M
$13.7M 0.54%
5,208,968
– –
AVBP icon
43
ArriVent BioPharma
AVBP
$1.44B
$12.9M 0.51%
700,000
– –
AMZN icon
44
Amazon
AMZN
$2.96T
$12.8M 0.5%
58,500
+2,000
+4% +$453K
ORIC icon
45
Oric Pharmaceuticals
ORIC
$1.4B
$12.1M 0.47%
1,007,575
– –
DNLI icon
46
Denali Therapeutics
DNLI
$3.97B
$11.9M 0.47%
821,513
– –
IONQ icon
47
IonQ
IONQ
$16.6B
$10.5M 0.41%
170,000
– –
SION
48
Sionna Therapeutics
SION
$2.31B
$9.56M 0.37%
325,000
– –
CRWD icon
49
CrowdStrike
CRWD
$218B
$9.07M 0.35%
74,000
– –
MSFT icon
50
Microsoft
MSFT
$3.71T
$8.88M 0.35%
17,150
+1,000
+6% +$510K
1
2
3 4 5

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Siren LLC's Q3 2025 Portfolio in Review

As of Q3 2025, Siren LLC held 133 positions worth $2.56B, up 32% from $1.93B the previous quarter. Its ten largest holdings account for 47% of the portfolio.

Siren LLC's Q3 2025 filing shows 23 new, 24 increased, 15 reduced and 18 closed positions. Its largest new stake was Rezolute: 4,870,000 shares worth $45.8M. The largest sale was Merus, an estimated $44.9M.

By sector, the portfolio is most concentrated in Healthcare at 91% of assets, up from 90% a quarter earlier, followed by Technology and Communication Services.

  • Siren LLC's largest Q3 2025 buy was Rezolute: 4,870,000 shares worth $45.8M.
  • Siren LLC added most to Remitly in Q3 2025, an estimated $19.8M increase.
  • Siren LLC's biggest Q3 2025 reduction was Disc Medicine, cutting an estimated $11.1M.
  • Siren LLC fully exited Merus in Q3 2025, selling an estimated $44.9M.
  • Siren LLC's ten largest holdings make up 47% of its $2.56B portfolio in Q3 2025.
  • Siren LLC opened 23 new positions and closed 18 in Q3 2025.
  • Siren LLC's portfolio value rose 32% quarter-over-quarter to $2.56B.

Based on Siren LLC's 13F filing for Q3 2025, filed 13 Nov 2025.