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HHMI

Howard Hughes Medical Institute Portfolio holdings

AUM $445M
1-Year Est. Return 42.75%
This Fund
S&P 500
This Quarter Est. Return
-7.04%
1 Year Est. Return
+42.75%
3 Year Est. Return
+70.92%
5 Year Est. Return
+91.54%
10 Year Est. Return
+350.22%
AUM
$416M
AUM Growth
+$241M
Cap. Flow
+$269M
Cap. Flow %
64.6%
Top 10 Hldgs %
83.32%
Holding
503
New
3
Increased
27
Reduced
1
Closed
472

Top Buys

Rank Stock Value
1
NVDA icon
NVIDIA
NVDA
+$58.1M
2
AAPL icon
Apple
AAPL
+$50.9M
3
GOOGL icon
Alphabet (Google) Class A
GOOGL
+$44.7M
4
MSFT icon
Microsoft
MSFT
+$42.1M
5
AMZN icon
Amazon
AMZN
+$28.8M

Top Sells

Rank Stock Value
1
SPY icon
State Street SPDR S&P 500 ETF Trust
SPY
+$102M
2
GOOG icon
Alphabet (Google) Class C
GOOG
+$314K
3
BRK.B icon
Berkshire Hathaway Class B
BRK.B
+$199K
4
JPM icon
JPMorgan Chase
JPM
+$189K
5
LLY icon
Eli Lilly
LLY
+$184K

Sector Composition

Rank Sector Weight
1 Technology 59.32%
2 Communication Services 16.1%
3 Consumer Discretionary 10.79%
4 Financials 0%
5 Healthcare 0%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
CNP icon
126
CenterPoint Energy
CNP
$26.9B
– –
-141
Closed -$5.41K
COF icon
127
Capital One
COF
$139B
– –
-137
Closed -$33.2K
COIN icon
128
Coinbase
COIN
$39.2B
– –
-48
Closed -$10.9K
COO icon
129
Cooper Companies
COO
$14.9B
– –
-43
Closed -$3.52K
COP icon
130
ConocoPhillips
COP
$152B
– –
-267
Closed -$25K
COR icon
131
Cencora
COR
$59.9B
– –
-41
Closed -$13.8K
COST icon
132
Costco
COST
$426B
– –
-95
Closed -$81.9K
CPB icon
133
Campbell Soup
CPB
$6.91B
– –
-42
Closed -$1.17K
CPRT icon
134
Copart
CPRT
$29.3B
– –
-191
Closed -$7.48K
CPT icon
135
Camden Property Trust
CPT
$11.1B
– –
-23
Closed -$2.53K
CRH icon
136
CRH
CRH
$64.6B
– –
-144
Closed -$18K
CRL icon
137
Charles River Laboratories
CRL
$13.4B
– –
-11
Closed -$2.19K
CRWD icon
138
CrowdStrike
CRWD
$221B
– –
-212
Closed -$24.8K
CSGP icon
139
CoStar Group
CSGP
$13.1B
– –
-91
Closed -$6.12K
CTAS icon
140
Cintas
CTAS
$79.8B
– –
-74
Closed -$13.9K
CSX icon
141
CSX Corp
CSX
$92.9B
– –
-401
Closed -$14.5K
CTRA
142
DELISTED
Coterra Energy
CTRA
– –
-163
Closed -$4.29K
CTSH icon
143
Cognizant
CTSH
$26.5B
– –
-104
Closed -$8.63K
CTVA icon
144
Corteva
CTVA
$51.2B
– –
-146
Closed -$9.79K
CVNA icon
145
Carvana
CVNA
$83.1B
– –
-150
Closed -$12.7K
CVS icon
146
CVS Health
CVS
$124B
– –
-273
Closed -$21.7K
CVX icon
147
Chevron
CVX
$392B
– –
-409
Closed -$62.3K
D icon
148
Dominion Energy
D
$60.5B
– –
-183
Closed -$10.7K
DAL icon
149
Delta Air Lines
DAL
$58.8B
– –
-139
Closed -$9.65K
DASH icon
150
DoorDash
DASH
$94B
– –
-80
Closed -$18.1K
4 5
6
7 8

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AC
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HIM
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HCM
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Howard Hughes Medical Institute's Q1 2026 Portfolio in Review

As of Q1 2026, Howard Hughes Medical Institute held 503 positions worth $416M, up 138% from $175M the previous quarter. Its ten largest holdings account for 83% of the portfolio.

Howard Hughes Medical Institute deployed $269M of net new capital in Q1 2026, opening 3 new positions and adding to 27 existing holdings. Its largest new stake was TSMC: 66,773 shares worth $22.6M.

By sector, the portfolio is most concentrated in Technology at 59% of assets, up from 2.5% a quarter earlier, followed by Communication Services and Consumer Discretionary.

On the sell side, the largest reduction was State Street SPDR S&P 500 ETF Trust, an estimated $102M trimmed.

  • Howard Hughes Medical Institute's largest Q1 2026 buy was TSMC: 66,773 shares worth $22.6M.
  • Howard Hughes Medical Institute added most to NVIDIA in Q1 2026, an estimated $58.1M increase.
  • Howard Hughes Medical Institute's biggest Q1 2026 reduction was State Street SPDR S&P 500 ETF Trust, cutting an estimated $102M.
  • Howard Hughes Medical Institute fully exited Alphabet (Google) Class C in Q1 2026, selling an estimated $314K.
  • Howard Hughes Medical Institute's ten largest holdings make up 83% of its $416M portfolio in Q1 2026.
  • Howard Hughes Medical Institute opened 3 new positions and closed 472 in Q1 2026.
  • Howard Hughes Medical Institute's portfolio value rose 138% quarter-over-quarter to $416M.

Based on Howard Hughes Medical Institute's 13F filing for Q1 2026, filed 15 May 2026.