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HHMI

Howard Hughes Medical Institute Portfolio holdings

AUM $416M
1-Year Est. Return 13.82%
This Fund
S&P 500
This Quarter Est. Return
+7.99%
1 Year Est. Return
+13.82%
3 Year Est. Return
+59.34%
5 Year Est. Return
+48.21%
10 Year Est. Return
+227.75%
AUM
$171M
AUM Growth
-$80.3M
Cap. Flow
-$96.1M
Cap. Flow %
-56.34%
Top 10 Hldgs %
95.55%
Holding
509
New
8
Increased
62
Reduced
141
Closed
9

Top Buys

Rank Stock Value
1
APP icon
Applovin
APP
+$26.7K
2
HOOD icon
Robinhood
HOOD
+$18.1K
3
AMZN icon
Amazon
AMZN
+$10.2K
4
DDOG icon
Datadog
DDOG
+$9.5K
5
XYZ
Block Inc
XYZ
+$8.91K

Top Sells

Rank Stock Value
1
SPY icon
State Street SPDR S&P 500 ETF Trust
SPY
+$96.2M
2
AAPL icon
Apple
AAPL
+$9.94K
3
HES
Hess
HES
+$8.17K
4
NVDA icon
NVIDIA
NVDA
+$7.84K
5
MSFT icon
Microsoft
MSFT
+$7.14K

Sector Composition

Rank Sector Weight
1 Technology 2.56%
2 Financials 0.95%
3 Consumer Discretionary 0.76%
4 Communication Services 0.75%
5 Healthcare 0.64%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
SPY icon
1
State Street SPDR S&P 500 ETF Trust
SPY
$810B
$158M 92.87%
237,885
-150,000
-39% -$96.2M
NVDA icon
2
NVIDIA
NVDA
$5.3T
$978K 0.57%
5,240
-45
-0.9% -$7.84K
MSFT icon
3
Microsoft
MSFT
$3.75T
$827K 0.48%
1,597
-14
-0.9% -$7.14K
AAPL icon
4
Apple
AAPL
$4.48T
$812K 0.48%
3,188
-44
-1% -$9.94K
AMZN icon
5
Amazon
AMZN
$2.99T
$458K 0.27%
2,084
+45
+2% +$10.2K
META icon
6
Meta Platforms (Facebook)
META
$1.51T
$342K 0.2%
466
-7
-1% -$5.21K
AVGO icon
7
Broadcom
AVGO
$2.02T
$334K 0.2%
1,011
– –
GOOGL icon
8
Alphabet (Google) Class A
GOOGL
$4.34T
$304K 0.18%
1,250
-10
-0.8% -$2.1K
TSLA icon
9
Tesla
TSLA
$1.3T
$268K 0.16%
602
+1
+0.2% +$347
GOOG icon
10
Alphabet (Google) Class C
GOOG
$4.32T
$244K 0.14%
1,003
-18
-2% -$3.78K
BRK.B icon
11
Berkshire Hathaway Class B
BRK.B
$1.14T
$198K 0.12%
394
-2
-0.5% -$969
JPM icon
12
JPMorgan Chase
JPM
$953B
$186K 0.11%
591
-14
-2% -$4.16K
LLY icon
13
Eli Lilly
LLY
$1.09T
$130K 0.08%
170
– –
V icon
14
Visa
V
$671B
$125K 0.07%
365
-7
-2% -$2.42K
NFLX icon
15
Netflix
NFLX
$315B
$110K 0.06%
920
– –
XOM icon
16
ExxonMobil
XOM
$661B
$103K 0.06%
916
-27
-3% -$3K
MA icon
17
Mastercard
MA
$490B
$101K 0.06%
177
+1
+0.6% +$574
ORCL icon
18
Oracle
ORCL
$437B
$99.8K 0.06%
355
+5
+1% +$1.27K
WMT icon
19
Walmart Inc
WMT
$891B
$97.1K 0.06%
942
+5
+0.5% +$498
JNJ icon
20
Johnson & Johnson
JNJ
$626B
$96K 0.06%
518
-2
-0.4% -$343
PLTR icon
21
Palantir
PLTR
$423B
$89K 0.05%
488
+47
+11% +$7.62K
ABBV icon
22
AbbVie
ABBV
$436B
$88K 0.05%
380
-1
-0.3% -$204
COST icon
23
Costco
COST
$419B
$87.9K 0.05%
95
– –
HD icon
24
Home Depot
HD
$348B
$86.7K 0.05%
214
– –
PG icon
25
Procter & Gamble
PG
$339B
$77.4K 0.05%
504
-2
-0.4% -$312
1
2 3 4 5

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SSC
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I
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ACM
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MCM
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MIA
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SP
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TI
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Howard Hughes Medical Institute's Q3 2025 Portfolio in Review

As of Q3 2025, Howard Hughes Medical Institute held 509 positions worth $171M, down 32% from $251M the previous quarter. Its ten largest holdings account for 96% of the portfolio.

Howard Hughes Medical Institute withdrew a net $96.1M in Q3 2025, closing 9 positions and reducing 141 holdings. Its most notable exit was Hess, an estimated $8.17K position sold in full.

By sector, the portfolio is most concentrated in Technology at 2.6% of assets, up from 1.6% a quarter earlier, followed by Financials and Consumer Discretionary.

Against the trend, Howard Hughes Medical Institute opened a new position in Applovin worth $41.7K.

  • Howard Hughes Medical Institute's largest Q3 2025 buy was Applovin: 58 shares worth $41.7K.
  • Howard Hughes Medical Institute added most to Amazon in Q3 2025, an estimated $10.2K increase.
  • Howard Hughes Medical Institute's biggest Q3 2025 reduction was State Street SPDR S&P 500 ETF Trust, cutting an estimated $96.2M.
  • Howard Hughes Medical Institute fully exited Hess in Q3 2025, selling an estimated $8.17K.
  • Howard Hughes Medical Institute's ten largest holdings make up 96% of its $171M portfolio in Q3 2025.
  • Howard Hughes Medical Institute opened 8 new positions and closed 9 in Q3 2025.
  • Howard Hughes Medical Institute's portfolio value fell 32% quarter-over-quarter to $171M.

Based on Howard Hughes Medical Institute's 13F filing for Q3 2025, filed 14 Nov 2025.