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HHMI

Howard Hughes Medical Institute Portfolio holdings

AUM $445M
1-Year Est. Return 42.75%
This Fund
S&P 500
This Quarter Est. Return
-7.04%
1 Year Est. Return
+42.75%
3 Year Est. Return
+70.92%
5 Year Est. Return
+91.54%
10 Year Est. Return
+350.22%
AUM
$416M
AUM Growth
+$241M
Cap. Flow
+$269M
Cap. Flow %
64.6%
Top 10 Hldgs %
83.32%
Holding
503
New
3
Increased
27
Reduced
1
Closed
472

Top Buys

Rank Stock Value
1
NVDA icon
NVIDIA
NVDA
+$58.1M
2
AAPL icon
Apple
AAPL
+$50.9M
3
GOOGL icon
Alphabet (Google) Class A
GOOGL
+$44.7M
4
MSFT icon
Microsoft
MSFT
+$42.1M
5
AMZN icon
Amazon
AMZN
+$28.8M

Top Sells

Rank Stock Value
1
SPY icon
State Street SPDR S&P 500 ETF Trust
SPY
+$102M
2
GOOG icon
Alphabet (Google) Class C
GOOG
+$314K
3
BRK.B icon
Berkshire Hathaway Class B
BRK.B
+$199K
4
JPM icon
JPMorgan Chase
JPM
+$189K
5
LLY icon
Eli Lilly
LLY
+$184K

Sector Composition

Rank Sector Weight
1 Technology 59.32%
2 Communication Services 16.1%
3 Consumer Discretionary 10.79%
4 Financials 0%
5 Healthcare 0%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
TDY icon
426
Teledyne Technologies
TDY
$31.5B
– –
-10
Closed -$5.11K
TECH icon
427
Bio-Techne
TECH
$11.3B
– –
-34
Closed -$2K
TEL icon
428
TE Connectivity
TEL
$62.6B
– –
-64
Closed -$14.6K
TER icon
429
Teradyne
TER
$65.5B
– –
-34
Closed -$6.58K
TFC icon
430
Truist Financial
TFC
$64.9B
– –
-276
Closed -$13.6K
TGT icon
431
Target
TGT
$70.2B
– –
-98
Closed -$9.58K
TJX icon
432
TJX Companies
TJX
$168B
– –
-240
Closed -$36.9K
TKO icon
433
TKO Group
TKO
$14.7B
– –
-14
Closed -$2.93K
TMO icon
434
Thermo Fisher Scientific
TMO
$218B
– –
-81
Closed -$46.9K
TMUS icon
435
T-Mobile US
TMUS
$196B
– –
-103
Closed -$20.9K
TPL icon
436
Texas Pacific Land
TPL
$24.7B
– –
-12
Closed -$3.45K
TPR icon
437
Tapestry
TPR
$26.1B
– –
-44
Closed -$5.62K
TRGP icon
438
Targa Resources
TRGP
$59.1B
– –
-47
Closed -$8.67K
TRMB icon
439
Trimble
TRMB
$13.4B
– –
-52
Closed -$4.07K
TROW icon
440
T. Rowe Price
TROW
$23.6B
– –
-48
Closed -$4.91K
TRV icon
441
Travelers Companies
TRV
$77.2B
– –
-49
Closed -$14.2K
TSCO icon
442
Tractor Supply
TSCO
$18.7B
– –
-114
Closed -$5.7K
TSN icon
443
Tyson Foods
TSN
$20.5B
– –
-61
Closed -$3.58K
TT icon
444
Trane Technologies
TT
$106B
– –
-48
Closed -$18.7K
TTD icon
445
Trade Desk
TTD
$6.64B
– –
-95
Closed -$3.61K
TTWO icon
446
Take-Two Interactive
TTWO
$46.2B
– –
-37
Closed -$9.47K
TXT icon
447
Textron
TXT
$15.3B
– –
-38
Closed -$3.31K
TYL icon
448
Tyler Technologies
TYL
$13.5B
– –
-9
Closed -$4.09K
UAL icon
449
United Airlines
UAL
$40.7B
– –
-70
Closed -$7.83K
UDR icon
450
UDR
UDR
$12.2B
– –
-65
Closed -$2.38K
16 17
18
19 20

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Howard Hughes Medical Institute's Q1 2026 Portfolio in Review

As of Q1 2026, Howard Hughes Medical Institute held 503 positions worth $416M, up 138% from $175M the previous quarter. Its ten largest holdings account for 83% of the portfolio.

Howard Hughes Medical Institute deployed $269M of net new capital in Q1 2026, opening 3 new positions and adding to 27 existing holdings. Its largest new stake was TSMC: 66,773 shares worth $22.6M.

By sector, the portfolio is most concentrated in Technology at 59% of assets, up from 2.5% a quarter earlier, followed by Communication Services and Consumer Discretionary.

On the sell side, the largest reduction was State Street SPDR S&P 500 ETF Trust, an estimated $102M trimmed.

  • Howard Hughes Medical Institute's largest Q1 2026 buy was TSMC: 66,773 shares worth $22.6M.
  • Howard Hughes Medical Institute added most to NVIDIA in Q1 2026, an estimated $58.1M increase.
  • Howard Hughes Medical Institute's biggest Q1 2026 reduction was State Street SPDR S&P 500 ETF Trust, cutting an estimated $102M.
  • Howard Hughes Medical Institute fully exited Alphabet (Google) Class C in Q1 2026, selling an estimated $314K.
  • Howard Hughes Medical Institute's ten largest holdings make up 83% of its $416M portfolio in Q1 2026.
  • Howard Hughes Medical Institute opened 3 new positions and closed 472 in Q1 2026.
  • Howard Hughes Medical Institute's portfolio value rose 138% quarter-over-quarter to $416M.

Based on Howard Hughes Medical Institute's 13F filing for Q1 2026, filed 15 May 2026.