D.E. Shaw & Co
TWST icon

D.E. Shaw & Co’s Twist Bioscience TWST Stock Holding History

D.E. Shaw & Co’s Portfolio TWST Stock Details TWST Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q2 		$122M Buy
1,185,605
+1,138,961
+2,442% +$74.1M 0.06% 376
2026
Q1 		$2.22M Buy
46,644
+19,063
+69% +$855K ﹤0.01% 2838
2025
Q4 		$875K Buy
+27,581
New +$861K ﹤0.01% 3628
2025
Q2 		– Sell
-5,689
Closed -$223K – 4725
2025
Q1 		$223K Sell
5,689
-101,579
-95% -$4.58M ﹤0.01% 3889
2024
Q4 		$4.98M Buy
107,268
+98,223
+1,086% +$4.44M ﹤0.01% 1983
2024
Q3 		$409K Buy
9,045
+4,971
+122% +$237K ﹤0.01% 3815
2024
Q2 		$201K Buy
+4,074
New +$166K ﹤0.01% 4075
2024
Q1 		– Sell
-368,531
Closed -$13.6M – 4752
2023
Q4 		$13.6M Buy
368,531
+175,266
+91% +$4.05M 0.01% 1166
2023
Q3 		$3.92M Buy
+193,265
New +$4.25M ﹤0.01% 2040
2023
Q1 		– Sell
-51,635
Closed -$1.23M – 4873
2022
Q4 		$1.23M Buy
51,635
+23,151
+81% +$671K ﹤0.01% 3296
2022
Q3 		$1M Sell
28,484
-74,653
-72% -$3.17M ﹤0.01% 3591
2022
Q2 		$3.61M Sell
103,137
-35,199
-25% -$1.25M ﹤0.01% 2534
2022
Q1 		$6.83M Sell
138,336
-59,798
-30% -$3.31M 0.01% 1979
2021
Q4 		$15.3M Sell
198,134
-97,022
-33% -$9.96M 0.01% 1289
2021
Q3 		$31.6M Sell
295,156
-69,867
-19% -$8M 0.03% 759
2021
Q2 		$48.6M Buy
365,023
+58,874
+19% +$6.84M 0.04% 563
2021
Q1 		$37.9M Sell
306,149
-216,309
-41% -$32.8M 0.04% 613
2020
Q4 		$73.8M Sell
522,458
-133,982
-20% -$14.9M 0.07% 354
2020
Q3 		$49.9M Buy
656,440
+134,822
+26% +$8.39M 0.05% 421
2020
Q2 		$23.6M Buy
521,618
+104,777
+25% +$3.76M 0.03% 697
2020
Q1 		$12.7M Buy
+416,841
New +$11.2M 0.02% 864
2019
Q2 		– Sell
-46,994
Closed -$1.09M – 3883
2019
Q1 		$1.09M Buy
46,994
+1,989
+4% +$44.9K ﹤0.01% 2563
2018
Q4 		$1.04M Buy
+45,005
New +$997K ﹤0.01% 2629

Other funds holding TWST

BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
Artisan Partners
Artisan Partners Milwaukee, Wisconsin $63.1B AUM 35.51% 1-Year Est. Return
Fidelity Investments
Fidelity Investments Boston, Massachusetts $2.3T AUM 54.33% 1-Year Est. Return
AIM
ARK Investment Management St. Petersburg, Florida $15.4B AUM 50.29% 1-Year Est. Return
T. Rowe Price Associates
T. Rowe Price Associates Baltimore, Maryland $999B AUM 46.22% 1-Year Est. Return
State Street
State Street Boston, Massachusetts $3.37T AUM 44.26% 1-Year Est. Return
Vanguard Portfolio Management
Vanguard Portfolio Management Malvern, Pennsylvania $2.22T AUM
Vanguard Capital Management
Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM
EIG
EdgePoint Investment Group Toronto, Ontario, Canada $13.2B AUM 32.43% 1-Year Est. Return
William Blair Investment Management
William Blair Investment Management Chicago, Illinois $33.3B AUM 44.76% 1-Year Est. Return

D.E. Shaw & Co's TWST Position: Q2 2026 in Review

D.E. Shaw & Co increased its Twist Bioscience (TWST) stake by 2,442% in Q2 2026, buying an estimated $74.1M and bringing the position to 1,185,605 shares worth $122M. The position accounts for 0.06% of the portfolio, ranked #376.

D.E. Shaw & Co first reported a position in TWST in Q4 2018 and has held it in 23 quarters since. 336 funds tracked by Wall St. Rank hold TWST as of Q2 2026.

  • D.E. Shaw & Co held 1,185,605 shares of Twist Bioscience worth $122M as of Q2 2026.
  • D.E. Shaw & Co bought 1,138,961 Twist Bioscience shares in Q2 2026, an estimated $74.1M.
  • Twist Bioscience made up 0.06% of D.E. Shaw & Co's portfolio in Q2 2026, its #376 holding.
  • D.E. Shaw & Co first reported a position in Twist Bioscience in Q4 2018 and has held it in 23 quarters since.
  • 336 funds tracked by Wall St. Rank held Twist Bioscience as of Q2 2026.

Based on D.E. Shaw & Co's 13F filing for Q2 2026, filed 14 Aug 2026.